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Recruitment of the IKK Signalosome to the p55 TNF Receptor

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Deterministic and Stochastic Models of NFκB Pathway

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Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20

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Transcriptomic analysis of Baltic cod (Gadus morhua) liver infected with Contracaecum osculatum third stage larvae indicates parasitic effects on growth and immune response

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Tumor necrosis factor α–induced proteins: Natural brakes on inflammation

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Negative Regulation of the Innate Immune Response through Proteasomal Degradation and Deubiquitination

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A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation

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A20 Overexpression Inhibits Lipopolysaccharide-Induced NF-κB Activation, TRAF6 and CD40 Expression in Rat Peritoneal Mesothelial Cells

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Role of the HTLV-1 viral factors in the induction of apoptosis

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Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis

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Associations Between TNFAIP3 Gene Polymorphisms and Rheumatoid Arthritis Risk: A Meta-analysis

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Synergistic Effects of Bortezomib-OV Therapy and Anti-Invasive Strategies in Glioblastoma: A Mathematical Model

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Identification of TNFAIP3 as relapse biomarker and potential therapeutic target for MOG antibody associated diseases

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Single-nucleotide Polymorphism and Haplotypes of TNIP1 Associated with Systemic Lupus Erythematosus in a Chinese Han Population

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Antioxidant Stress and Anti-Inflammation of PPARαon Warm Hepatic Ischemia-Reperfusion Injury

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hCINAP negatively regulates NF-κB signaling by recruiting the phosphatase PP1 to deactivate IKK complex

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Involvement of Ubiquitin-Editing Protein A20 in Modulating Inflammation in Rat Cochlea Associated with Silver Nanoparticle-Induced CD68 Upregulation and TLR4 Activation

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A novel missense mutation in TNFAIP3 causes haploinsufficiency of A20

Jiang, W. H., Deng, M., Gan, C., Wang, L., Mao, H., & Li, Q. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2021.104453 · Cited by 17

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB

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Skin manifestations of inborn errors of NF-κB

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Ultrasound and neuroinflammation: immune modulation via the heat shock response

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Role of ubiquitination in the occurrence and development of osteoporosis (Review)

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Proteins that bind to IKKγ (NEMO) and down-regulate the activation of NF-κB

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Effect of time-varied magnetic field on inflammatory response in macrophage cell line RAW 264.7

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Highlights of the advances in basic immunology in 2011

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Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis

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Stress associated protein from Lobularia maritima: Heterologous expression, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in beef meat

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Negative regulation of human mononuclear phagocyte function

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A Th1-inducing Adenoviral Vaccine for Boosting Adoptively Transferred T Cells

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Escape from Transcriptional Shutoff during Poliovirus Infection: NF-κB-Responsive Genes IκBa and A20

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Anti-inflammatory subtilase cytotoxin up-regulates A20 through the unfolded protein response

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Host Response to Orthopedic Implants (Metals and Plastics)

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Ubiquitylation within signaling pathways in- and outside of inflammation

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Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-κB signaling at the single cell level

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Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20

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Three Chinese pedigrees of A20 haploinsufficiency: clinical, cytokine and molecular characterization

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A20 ameliorates Aspergillus fumigatus keratitis by promoting autophagy and inhibiting NF-κB signaling

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Nonself RNA rewires IFN-β signaling: A mathematical model of the innate immune response

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Research progress on plant stress‐associated protein (SAP) family: Master regulators to deal with environmental stresses

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A20 Is Induced by Kaposi Sarcoma-associated Herpesvirus-encoded Viral FLICE Inhibitory Protein (vFLIP) K13 and Blocks K13-induced Nuclear Factor-κB in a Negative Feedback Manner

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Immune defects caused by mutations in the ubiquitin system

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A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function

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TNFAIP3 mutation causing haploinsufficiency of A20 with a hemophagocytic lymphohistiocytosis phenotype: a report of two cases

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The polymorphisms of tumor necrosis factor-induced protein 3 gene may contribute to the susceptibility of chronic primary immune thrombocytopenia in Chinese population

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Adapter and enzymatic functions of proteases in T‐cell activation

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Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling

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Importins promote high-frequency NF-κB oscillations increasing information channel capacity

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The zinc finger protein A20 protects endothelial cells from burns serum injury

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Specific overexpression of tumour necrosis factor-α-induced protein (TNFAIP)9 in CD14+CD16− monocytes in patients with rheumatoid arthritis: comparative analysis with TNFAIP3

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Toll-like receptor 2 signaling in liver pathophysiology

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Deleterious variants in TNFAIP3 are associated with type II and seronegative pediatric autoimmune hepatitis

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Therapeutic CRISPR epigenome editing of inflammatory receptors in the intervertebral disc

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The Straw That Stirs the Drink: Insight into the Pathogenesis of Inflammatory Bowel Disease Revealed Through the Study of Microflora-Induced Inflammation in Genetically Modified Mice

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Inhibition of NF-κB signaling via tyrosine phosphorylation of Ymer

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Expression of platelet-derived growth factor in the vascular walls of patients with lower extremity arterial occlusive disease

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New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways

Asaoka, T., & Ikeda, F. (2015) · International review of cytology · doi:10.1016/bs.ircmb.2015.05.003 · Cited by 15

Ymer Acts as a Multifunctional Regulator in Nuclear Factor-κB and Fas Signaling Pathways

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A20 protein regulates lipopolysaccharide-induced acute lung injury by downregulation of NF-κB and macrophage polarization in rats

Wang, Y., Song, Z., Bi, J., Liu, J., Tong, L., Song, Y., Bai, C., & Zhu, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7184 · Cited by 15

Association of zinc administration with growth suppression of intracranial aneurysms via induction of A20

Hayashi, K., Kataoka, H., Minami, M., Ikedo, T., Miyata, T., Shimizu, K., Nagata, M., Yang, T., Yamamoto, Y., Yokode, M., et al. (2020) · Journal of neurosurgery · doi:10.3171/2020.1.jns192047 · Cited by 15

Itch regulation of innate and adaptive immune responses in mice and humans

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Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis

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At the intersection of sulfur redox chemistry, cellular signal transduction and proteostasis: A useful perspective from which to understand and treat neurodegeneration

Hensley, K., Danekas, A., Farrell, W., Garcia, T. M. D. N., Mehboob, W., & White, M. C. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.039 · Cited by 15

Functional Effect of Polymorphisms in the Promoter of TNFAIP3 (A20) in Acute Pancreatitis in the Han Chinese Population

Liu, Y., Dan, G., Wu, L., Chen, G., Wu, A.-L., Zeng, P., & Xu, W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103104 · Cited by 15

Induction of Protective Genes Leads to Islet Survival and Function

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Zinc finger protein 365 is a new maternal LPS‐binding protein that defends zebrafish embryos against gram‐negative bacterial infections

Du, X., Zhou, Y., Song, L., Wang, X., & Zhang, S. (2017) · The FASEB Journal · doi:10.1096/fj.201700694r · Cited by 15

SR-A1 suppresses colon inflammation and tumorigenesis through negative regulation of NF-κB signaling

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Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20

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Current understanding of the genetic basis of psoriasis

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Apparently Normal Tumor Necrosis Factor Receptor 1 Signaling in the Absence of the Silencer of Death Domains

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CARP2 deficiency does not alter induction of NF-κB by TNFα

Ahmed, A. U., Moulin, M., Coumailleau, F., Wong, W. W.-L., Miasari, M., Carter, H., Silke, J., Cohen‐Tannoudji, M., Vince, J. E., & Vaux, D. L. (2009) · Current Biology · doi:10.1016/j.cub.2008.11.040 · Cited by 15

Ripoptocide – A Spark for Inflammation

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Role of A20 in interferon‐α‐mediated functional restoration of myeloid dendritic cells in patients with chronic hepatitis C

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TNFAIP3 Gene Polymorphisms in a Chinese Han Population with Vogt–Koyanagi–Harada Syndrome

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Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus risk: an updated meta‐analysis

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The Complex Role of the ZNF224 Transcription Factor in Cancer.

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Beclin-1 overexpression regulates NLRP3 activation by promoting TNFAIP3 in microvascular injury following myocardial reperfusion

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Ubiquitination is a major modulator for the activation of inflammasomes and pyroptosis

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RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells

Pranski, E. L., Dalal, N. V., Sanford, C. V., Herskowitz, J. H., Gearing, M., Lazo, C. R., Miller, G. W., Lah, J. J., Levey, A. I., & Betarbet, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.018 · Cited by 14

NF-κB and Therapeutic Approach

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Does Antigen Masking by Ubiquitin Chains Protect from the Development of Autoimmune Diseases?

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Interaction between misfolded PrP and the ubiquitin-proteasome system in prion-mediated neurodegeneration

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Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression

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Genome editing to define the function of risk loci and variants in rheumatic disease

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Experimental Models of Mucosal Inflammation

Strober, W., & Fuss, I. J. (2006) · Advances in experimental medicine and biology · doi:10.1007/0-387-33778-4_5 · Cited by 14

Tryptophol Acetate and Tyrosol Acetate, Small-Molecule Metabolites Identified in a Probiotic Mixture, Inhibit Hyperinflammation

Malka, O., Malishev, R., Bersudsky, M., Manikandan, R., Krishnamohan, M., Shaik, J., Chamovitz, D., Tikhonov, E., Sultan, E., Koren, O., et al. (2023) · Journal of Innate Immunity · doi:10.1159/000529782 · Cited by 13

In the moonlight: non-catalytic functions of ubiquitin and ubiquitin-like proteases

Alonso, M. C., & Knobeloch, K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1349509 · Cited by 13

Deubiquitinating enzyme A20 negatively regulates NF‐κB signaling in skeletal muscle in mdx mice

Charan, R. A., Hanson, R., & Clemens, P. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-189829 · Cited by 13

A20 restricts inflammation via ubiquitin binding

Sun, S. (2020) · Nature Immunology · doi:10.1038/s41590-020-0632-6 · Cited by 13

Deubiquitinating Enzyme: A Potential Secondary Checkpoint of Cancer Immunity

Huang, X., Zhang, X., Xu, J., Wang, X., Zhang, G., Tang, T., Shen, X., Liang, T., & Bai, X. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01289 · Cited by 13

A20 functions as a negative regulator in macrophage for DSS-induced colitis

Tian, P., Liu, W., Wu, Y., & Zhao, Y. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107804 · Cited by 13

Comprehensive analysis of hub biomarkers associated with immune and oxidative stress in Hashimoto's thyroiditis

Xu, B., Huang, S., Peng, W., Cai, G., Zhou, H., Guo, Y., Du, J., Ge, X., & Wu, X. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109713 · Cited by 13

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

Filkor, K., Hegedüs, Z., Szász, A., Tubak, V., Kemény, L. V., Kondorosi, É., & Nagy, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073435 · Cited by 14

A20: attractive without showing cleavage

Verhelst, K., Loo, G., & Beyaert, R. (2014) · EMBO Reports · doi:10.15252/embr.201439014 · Cited by 13

Refeeding with glucose rather than fructose elicits greater hepatic inflammatory gene expression in mice

Oarada, M., Takahashi‐Nakaguchi, A., Abe, T., Nikawa, T., Miki, T., & Gonoi, T. (2014) · Nutrition · doi:10.1016/j.nut.2014.11.014 · Cited by 13

Intron-derived aberrant splicing of A20 transcript in rheumatoid arthritis

Yoon, H. K., Byun, H. S., Lee, H. S., Jeon, J., Lee, Y., Li, Y., Jin, E.-H., Kim, J., Hong, J. H., Kim, J., et al. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/kes292 · Cited by 13

The transfection of A20 gene prevents kidney from ischemia reperfusion injury in rats

Wei, L., Zhang, X., Ye, Q., Yang, Y., & Chen, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6725 · Cited by 13

A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics

Mothes, J., Ipenberg, I., Arslan, S. Ç., Benary, U., Scheidereit, C., & Wolf, J. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00896 · Cited by 13

A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-κB activation

Zhang, B., Guan, C.-C., Wan-tao, C. H. E. N., Zhang, P., Yan, M., Jiu-hui, S. H. I., Qin, C., & Yang, Q. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200710020-00020 · Cited by 13

A CRM 1‐Dependent Nuclear Export Signal Controls Nucleocytoplasmic Translocation of HSCARG , Which Regulates NF‐κB Activity

Zhang, M., Hu, B., Li, T., Peng, Y., Guan, J., Lai, S., & Zheng, X. (2012) · Traffic · doi:10.1111/j.1600-0854.2012.01346.x · Cited by 13

Sniping the scout: Targeting the key molecules in dendritic cell functions for treatment of autoimmune diseases

Li, X., Han, Y., & Sun, E. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.02.023 · Cited by 13

Dysregulation of Cell Death in Human Chronic InflammationPreprint

Li, Y., Klein, C., & Kotlarz, D. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037036 · Cited by 15

A20 and cell death-driven inflammation

Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139

A20 at the Crossroads of Cell Death, Inflammation, and AutoimmunityPreprint

Martens, A., & Loo, G. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036418 · Cited by 142

A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death in keratinocytes

Panayotova‐Dimitrova, D., & Feoktistova, M. (2019) · doi:10.26226/morressier.5d4980cf8fb7e44098e72fd2

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis

Beyaert, R., Heyninck, K., & Huffel, S. V. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00404-4 · Cited by 302

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295