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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Open accessAbstract
A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor κB (NF-κB) activity and tumor necrosis factor (TNF)–mediated programmed cell death (PCD). TNF dramatically increases A20 messenger RNA expression in all tissues. Mice deficient for A20 develop severe inflammation and cachexia, are hypersensitive to both lipopolysaccharide and TNF, and die prematurely. A20-deficient cells fail to terminate TNF-induced NF-κB responses. These cells are also more susceptible than control cells to undergo TNF-mediated PCD. Thus, A20 is critical for limiting inflammation by terminating TNF-induced NF-κB responses in vivo.
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“A20 KO mice are born cachectic and die within 4–5 weeks of birth mainly from unfettered liver inflammation, which shows A20’s high rank in the hierarchy of the liver physiologic anti-inflammatory armamentarium (21).”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [21]
In the citing paper
“TNFAIP3 is a deubiquitinating enzyme and inhibits TNF-mediated apoptosis38, whereas HMOX1 is involved in the initial step of haem degradation and has been shown to have antioxidant and anti-inflammatory effects38,39.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
In the citing paper
“Although overlapping in their anti-apoptotic activities, TNFAIP3 and HMOX1 achieve this outcome by their unique biological functions and dampen inflammation under distinct circumstances.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
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Metadata
- Authors
- Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Lee, Eric G.
- Boone, David L.
- Ma, Averil
- Venue
- Science
- Published
- 2000-09-29
- Volume
- 289
- Issue
- 5488
- Pages
- 2350-2354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3582399
- OpenAlex
- W1993936200
- Cited by
- 1,409
- References
- 19
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 43 · 2023: 33 · 2022: 44 · 2021: 53 · 2020: 57 · 2019: 65 · 2018: 46 · 2017: 68 · 2016: 75 · 2015: 76 · 2014: 72 · 2013: 88 · 2012: 69
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007183, 5T32 GM-07183, T32GM007839, T32GM07839)
- National Institute of Allergy and Infectious Diseases (R01AI045860)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052751)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- A20, NF-κB, TNF-α, programmed cell death, TNF-induced cell death, inflammation, cachexia, zinc finger proteins
- MeSH terms
- NF-KappaB Inhibitor alpha, Tumor Necrosis Factor alpha-Induced Protein 3, Animals, Cachexia, Cells, Cultured, Cysteine Endopeptidases, DNA, DNA-Binding Proteins, Fibroblasts, Inflammation, Interleukin-1, Intestines, Kidney, Lipopolysaccharides, Liver, Nuclear Proteins, Phosphorylation, Proteins, Skin, T-Lymphocytes, Tumor Necrosis Factor-alpha, NF-kappa B, Zinc Fingers, Apoptosis, Gene Targeting, I-kappa B Proteins, Intracellular Signaling Peptides and Proteins, Mice
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