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Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Open accessAbstract
A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor κB (NF-κB) activity and tumor necrosis factor (TNF)–mediated programmed cell death (PCD). TNF dramatically increases A20 messenger RNA expression in all tissues. Mice deficient for A20 develop severe inflammation and cachexia, are hypersensitive to both lipopolysaccharide and TNF, and die prematurely. A20-deficient cells fail to terminate TNF-induced NF-κB responses. These cells are also more susceptible than control cells to undergo TNF-mediated PCD. Thus, A20 is critical for limiting inflammation by terminating TNF-induced NF-κB responses in vivo.
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“A20 KO mice are born cachectic and die within 4–5 weeks of birth mainly from unfettered liver inflammation, which shows A20’s high rank in the hierarchy of the liver physiologic anti-inflammatory armamentarium (21).”
From A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals (2013) · cites this paper as [21]
In the citing paper
“TNFAIP3 is a deubiquitinating enzyme and inhibits TNF-mediated apoptosis38, whereas HMOX1 is involved in the initial step of haem degradation and has been shown to have antioxidant and anti-inflammatory effects38,39.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
In the citing paper
“Although overlapping in their anti-apoptotic activities, TNFAIP3 and HMOX1 achieve this outcome by their unique biological functions and dampen inflammation under distinct circumstances.”
From Design and testing of a humanized porcine donor for xenotransplantation (2023) · cites this paper as [38]
Citations
Cites
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518
Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice
Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479
Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 466
Recruitment of the IKK Signalosome to the p55 TNF Receptor
Zhang, S. Q., Kovalenko, A., Cantarella, G., & Wallach, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80183-1 · Cited by 456
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Items 601–700 of 1,000
Yan, K., Wu, C., Ye, Y., Li, L., Wang, X., He, W., Ren, S., & Xu, Y. (2020) · Cell Proliferation · doi:10.1111/cpr.12778 · Cited by 47
Resolving mechanisms of immune‐mediated disease in primary CD4 T cells
Bourges, C., Groff, A. F., Burren, O. S., Gerhardinger, C., Mattioli, K., Hutchinson, A., Hu, T. X., Anand, T., Epping, M. W., Wallace, C., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012112 · Cited by 45
Yuan, W., Chen, Y., Zhou, Y., Bao, K., Yu, X., Xu, Y., Zhang, Y., Zheng, J., Jiang, G., & Hong, M. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113397 · Cited by 47
An inhibitory effect of A20 on NF-κB activation in airway epithelium upon influenza virus infection
Onose, A., Hashimoto, S., Hayashi, S., Maruoka, S., Kumasawa, F., Mizumura, K., Jibiki, I., Matsumoto, K., Gon, Y., Kobayashi, T., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.03.073 · Cited by 47
Relić, B., Bentires‐Alj, M., Ribbens, C., Franchimont, N., Guerne, P., Benoît, V., Merville, M., Bours, V., & Malaise, M. (2002) · Laboratory Investigation · doi:10.1097/01.lab.0000041714.05322.c0 · Cited by 47
Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS
Duan, R., Leo, P., Bradbury, L. A., Brown, M. A., & Thomas, G. P. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.111690 · Cited by 47
Signaling to gene activation and cell death by tumor necrosis factor receptors and fas
Beyaert, R., Loo, G., Heyninck, K., & Vandenabeele, P. (2002) · International review of cytology · doi:10.1016/s0074-7696(02)14007-1 · Cited by 47
Kunter, U., Floege, J., rgensonn, A. S. V. J., Stojanović, T., Merkel, S., ne, H. J. G., & Ferran, C. J. (2003) · Transplantation · doi:10.1097/00007890-200301150-00002 · Cited by 47
Ubiquitin-modifying enzymes as regulators of colitis
Ruan, J., Schlüter, D., Naumann, M., Waisman, A., & Wang, X. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.01.006 · Cited by 46
A20 Regulation of Nuclear Factor–κB
Kelly, C., Shields, M. D., Elborn, J. S., & Schock, B. C. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0339tr · Cited by 46
Crosstalk between p53 and nuclear factor-κB systems: pro- and anti-apoptotic functions of NF-κB
Puszyński, K., Bertolusso, R., & Tomasz Lipniacki, B. (2009) · IET Systems Biology · doi:10.1049/iet-syb.2008.0172 · Cited by 46
Localization of A20 to a lysosome-associated compartment and its role in NFκB signaling
Li, L., Hailey, D. W., Soetandyo, N., Li, W. S., Lippincott‐Schwartz, J., Shu, H., & Ye, Y. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.029 · Cited by 46
Ramsey, H. E., Da Silva, C. G., Longo, C. R., Csizmadia, E., Studer, P., Patel, V. I., Damrauer, S. M., Siracuse, J. J., Daniel, S., & Ferran, C. (2009) · Liver Transplantation · doi:10.1002/lt.21879 · Cited by 46
Lutz, J., Luong, L. A., Strobl, M., Deng, M., Huang, H., Anton, M., Zakkar, M., Enesa, K., Chaudhury, H., Haskard, D. O., et al. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0405-4 · Cited by 46
Role of NF-κB in Endotoxemia-Induced Alterations of Lung Neutrophil Apoptosis
Kupfner, J., Arcaroli, J. J., Yum, H.-K., Nadler, S. G., Yang, K., & Abraham, E. H. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.12.7044 · Cited by 46
Deubiquitinases as novel therapeutic targets for diseases
Xian, Y., Ye, J., Tang, Y., Zhang, N., Peng, C. Y., Huang, W., & He, G. (2024) · MedComm · doi:10.1002/mco2.70036 · Cited by 49
Yang, C., & Jiang, Q. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.10.013 · Cited by 47
Last, J. A., Gohil, K., Mathrani, V. C., & Kenyon, N. J. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.02.001 · Cited by 45
Zetoune, F. S., Murthy, A. R., Shao, Z., Hlaing, T., Zeidler, M. G., Li, Y., & Vincenz, C. (2001) · Cytokine · doi:10.1006/cyto.2001.0921 · Cited by 45
Saad, R. B., Romdhane, W. B., Zouari, N., Azaza, J., Mieulet, D., Verdeil, J., Guiderdoni, E., & Hassairi, A. (2010) · Transgenic Research · doi:10.1007/s11248-010-9474-6 · Cited by 44
Paving TRAIL’s Path with Ubiquitin
Lafont, É., Hartwig, T., & Walczak, H. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.11.002 · Cited by 45
Transcriptional and epigenetic regulation of immune tolerance: roles of the NF-κB family members
Zhang, L., Xiao, X., Arnold, P. R., & Li, X. C. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0202-8 · Cited by 45
Ning, X., & Sun, L. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.11.033 · Cited by 44
SIGNALING ACTIVATED BY THE DEATH RECEPTORS OF THE TNFR FAMILY
Anděra, L. (2009) · Biomedical Papers · doi:10.5507/bp.2009.029 · Cited by 47
Genetics of rheumatoid arthritis: GWAS and beyond
Orozco, G., Duffus, K., & Eyre, S. (2011) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s14725 · Cited by 50
Han, D., Fang, W., Zhang, R., Wei, J., Kodithuwakku, N. D., Sha, L., Ma, W., liu, L., Li, F., & Li, Y. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.07.025 · Cited by 43
Lu, X., Rudemiller, N. P., Wen, Y., Ren, J., Hammer, G. E., Griffiths, R., Privratsky, J. R., Yang, B., Sparks, M. A., & Crowley, S. D. (2019) · Circulation Research · doi:10.1161/circresaha.119.315343 · Cited by 44
Kupka, S., Reichert, M., Dráber, P., & Walczak, H. (2016) · FEBS Journal · doi:10.1111/febs.13644 · Cited by 41
Genetics in ankylosing spondylitis – Current state of the art and translation into clinical outcomes
Brown, M. A., & Wordsworth, B. P. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2018.09.005 · Cited by 42
Li, H., Wang, A., Zhang, R., Wei, Y., Chen, H., She, Z., Huang, Y., Liu, D., & Liang, C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20665 · Cited by 42
Zhu, L., Wang, L., Wang, X., Zhou, L., Liao, Z., Xu, L., Wu, H., Ren, J., Li, Z., Yang, L., et al. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0566-1 · Cited by 41
Yan, Y., Fan, J., Bai, S., Hou, W., Li, X., & Tong, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148536 · Cited by 41
Wang, S., Wen, F., Tessneer, K. L., & Gaffney, P. M. (2016) · Genes and Immunity · doi:10.1038/gene.2016.4 · Cited by 41
Post-translational control of NF-κB signaling by ubiquitination
Won, M., Byun, H. S., Park, K. A., & Hur, G. M. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0772-2 · Cited by 41
Yao, D., Xu, L., Xu, O., Li, R., Chen, M., Shen, H., Zhu, H., Zhang, F., Yao, D., Chen, Y.-F., et al. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310468 · Cited by 41
Hyeon, J., Lee, B., Shin, S., Yoo, H. Y., Kim, S. J., Kim, W. S., Park, W., & Ko, Y. H. (2018) · Modern Pathology · doi:10.1038/s41379-018-0064-0 · Cited by 43
Rosa, L. B., Lima, R. L. A., Oliveira, L. D. S., Fontes, J. V., Miguel, D. C., & Abbehausen, C. (2021) · ChemMedChem · doi:10.1002/cmdc.202100022 · Cited by 40
Yang, S.-K., Wang, Y., Chao, C., Chuang, Y., Lan, C., & Chen, B.-S. (2010) · BMC Medical Genomics · doi:10.1186/1755-8794-3-19 · Cited by 41
Sakakibara, S., Pise-Masison, C. A., Brady, J. N., & Tosato, G. (2008) · Journal of Virology · doi:10.1128/jvi.01871-08 · Cited by 41
Deubiquitinases in Neurodegeneration
Bello, A. I., Goswami, R., Brown, S. L., Costanzo, K. M., Shores, T., Allan, S. K., Odah, R., & Mohan, R. D. (2022) · Cells · doi:10.3390/cells11030556 · Cited by 42
Luo, C., Zhang, R., Guo, R., Wu, L., Xue, T., He, Y., Jin, Y., Zhao, Y., Zhang, Z., Zhang, P., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.02.007 · Cited by 37
Contribution of Genetic Factors to Sjögren’s Syndrome and Sjögren’s Syndrome Related Lymphomagenesis
Nezos, A., & Mavragani, C. P. (2015) · Journal of Immunology Research · doi:10.1155/2015/754825 · Cited by 40
Zhao, H., Wang, L., Luo, H., Li, Q., & Zuo, X. (2017) · Rheumatology · doi:10.1093/rheumatology/kew508 · Cited by 40
Peroumal, D., Sahu, S. R., Kumari, P., Utkalaja, B. G., & Acharya, N. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02462-22 · Cited by 40
Bohgaki, M., Tsukiyama, T., Nakajima, A., Maruyama, S., Watanabe, M., Koike, T., & Hatakeyama, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.09.006 · Cited by 40
Lin, A. E., Ebert, G., Ow, Y., Preston, S., Toe, J. G., Cooney, J. P., Scott, H. W., Sasaki, M., Saibil, S. D., Dissanayake, D., et al. (2012) · Nature Immunology · doi:10.1038/ni.2478 · Cited by 39
Chudnovskiy, A., Castro, T. B. R., Nakandakari-Higa, S., Cui, A., Lin, C., Sade-Feldman, M., Phillips, B. K., Pae, J., Mesin, L., Bortolatto, J., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.adq8843 · Cited by 41
Duffin, K. C., Woodcock, J. L., & Krueger, G. G. (2010) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2010.01303.x · Cited by 39
Hong, J., Bae, W. ‐., Yi, J.-K., Kim, G., & Kim, E. ‐. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12332 · Cited by 40
Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds
Liu, N., Huang, H., Dou, Q. P., & Liu, J. (2015) · Oncoscience · doi:10.18632/oncoscience.167 · Cited by 43
Dai, W.-W., Wu, F., McMyn, N. F., Song, B., Walker-Sperling, V. E. K., Varriale, J., Zhang, H., Barouch, D., Siliciano, J., Li, W., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abh3351 · Cited by 35
Modulation of apoptosis and immune signaling pathways by the Hantaan virus nucleocapsid protein
Ontiveros, S. J., Li, Q., & Jonsson, C. B. (2010) · Virology · doi:10.1016/j.virol.2010.02.018 · Cited by 39
Danneels, E., Gerlo, S., Heyninck, K., Craenenbroeck, K. V., Bosscher, K. D., Haegeman, G., & de Graaf, D. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096825 · Cited by 41
Sukocheva, O. A., Неганова, М. Е., Aleksandrova, Y. R., Burcher, J. T., Chugunova, E., Fan, R., Tse, E., Sethi, G., Bishayee, A., & Liu, J. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01626-6 · Cited by 42
A20 edits ubiquitin and autoimmune paradigms
Martin, F., & Dixit, V. M. (2011) · Nature Genetics · doi:10.1038/ng.916 · Cited by 38
Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes
Schlatter, R., Schmich, K., Lutz, A., Trefzger, J., Sawodny, O., Ederer, M., & Merfort, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018646 · Cited by 38
Drugs targeting toll-like receptors
Krishnan, J., Lee, G., & Choi, S. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-2100-6 · Cited by 38
Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity
Kanayama, M., & Shinohara, M. L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00047 · Cited by 40
A20 Restrains Thymic Regulatory T Cell Development
Fischer, J. C., Otten, V., Kober, M., Drees, C., Rosenbaum, M., Schmickl, M., Heidegger, S. M., Beyaert, R., Loo, G., Li, X. C., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602102 · Cited by 38
Wu, A., Tymoszuk, P., Haschka, D., Heeke, S., Dichtl, S., Petzer, V., Seifert, M., Hilbe, R., Sopper, S., Talasz, H., et al. (2017) · Infection and Immunity · doi:10.1128/iai.00418-17 · Cited by 39
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Zammit, N. W., Walters, S. N., Seeberger, K. L., O’Connell, P. J., Korbutt, G. S., & Grey, S. T. (2019) · JCI Insight · doi:10.1172/jci.insight.131028 · Cited by 38
Deconstructing innate immune signaling in myelodysplastic syndromes
Varney, M. E., Melgar, K., Niederkorn, M., Smith, M. A., Barreyro, L., & Starczynowski, D. T. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.05.016 · Cited by 38
c-Jun N-terminal kinases as potential therapeutic targets
Salh, B. S. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.10.1339 · Cited by 38
A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB
Stilo, R., Varricchio, E., Liguoro, D., Leonardi, A., & Vito, P. (2008) · Journal of Cell Science · doi:10.1242/jcs.021105 · Cited by 38
Transcription of Tnfaip3 Is Regulated by NF-κB and p38 via C/EBPβ in Activated Macrophages
Lai, T., Wu, S.-D., Tsai, M., Chuang, E. Y.-Y., Chuang, L.-L., Hsu, L.-C., & Lai, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073153 · Cited by 39
Nititham, J., Taylor, K. E., Gupta, R., Chen, H., Ahn, R. S., Liu, J., Seielstad, M. T., Ma, A. I., Bowcock, A. M., Criswell, L. A., et al. (2014) · Genes and Immunity · doi:10.1038/gene.2014.75 · Cited by 37
Self-citationPathway-based analysis using reduced gene subsets in genome-wide association studies
Zhao, J., Gupta, S., Seielstad, M. T., Liu, J., & Thalamuthu, A. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-17 · Cited by 37
Sokhi, U. K., Liber, M. P., Frye, L., Park, S., Kang, K., Pannellini, T., Zhao, B., Norinsky, R., Ivashkiv, L. B., & Gong, S. (2018) · Nature Communications · doi:10.1038/s41467-018-03081-7 · Cited by 37
A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
Guo, Q., Dong, H., Liu, X., Wang, C., Liu, N., Zhang, J., Li, B., Cao, W., Ding, T., Yang, Z., et al. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903045018 · Cited by 37
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Damrauer, S. M., Studer, P., da Silva, C. G., Longo, C. R., Ramsey, H. E., Csizmadia, E., Shrikhande, G., Scali, S. T., Libermann, T. A., Bhasin, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017715 · Cited by 37
Vetters, J., van Helden, M. J. G., Wahlen, S., Tavernier, S. J., Martens, A., Fayazpour, F., Vergote, K., Vanheerswynghels, M., Deswarte, K., Moorleghem, J. V., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182164 · Cited by 38
A20 expression in dendritic cells protects mice from LPS‐induced mortality
Xuân, N. T., Wang, X., Nishanth, G., Waisman, A., Borucki, K., Isermann, B., Naumann, M., Deckert, M., & Schlüter, D. (2014) · European Journal of Immunology · doi:10.1002/eji.201444795 · Cited by 38
Bhattacharyya, S., Wang, W., Graham, L. V. D., & Varga, J. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-1118-7 · Cited by 36
Zheng, C., Huang, Y., Ye, Z., Wang, Y., Tang, Z., Lu, J., Wu, J., Zhou, Y., Wang, L., Huang, Z., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy165 · Cited by 36
Li, Z., Chu, S., He, W., Zhang, Z., Liu, J., Cui, L., Xu, Y., Li, D., & Chen, N. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.005 · Cited by 36
Vela, V., Juškevičius, D., Gerlach, M. M., Meyer, P., Graber, A., Cathomas, G., Dirnhofer, S., & Tzankov, A. (2020) · Hematological Oncology · doi:10.1002/hon.2718 · Cited by 36
Zhu, Y.-Q., & Tan, X. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2005 · Cited by 36
Li, S., Zhu, J., Fu, H., Wan, J., Hu, Z., Liu, S., Li, J., Tie, Y., Xing, R., Zhu, J., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr715 · Cited by 36
Schotte, P., Loo, G., Carpentier, I., Vandenabeele, P., & Beyaert, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104014200 · Cited by 36
Lin, J., & Hackam, D. J. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007252 · Cited by 36
Update on the genetic risk factors for rheumatoid arthritis
Orozco, G., & Barton, A. C. (2009) · Expert Review of Clinical Immunology · doi:10.1586/eci.09.72 · Cited by 36
Characterization of Transcriptional Regulation During Negative Selection In Vivo
DeRyckere, D., Mann, D. L., & DeGregori, J. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.802 · Cited by 36
De, S. K., Devadas, K., & Notkins, A. L. (2002) · Journal of Virology · doi:10.1128/jvi.76.22.11710-11714.2002 · Cited by 36
Chen, Y., Yan, H., Song, Z., Chen, F., Wang, H., Niu, J., Shi, X., Zhang, D., Zhang, N., Zhai, Z., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127957 · Cited by 37
Deletion of the TNFAIP3/A20gene detected by FICTION analysis in classical Hodgkin lymphoma
Nomoto, J., Hiramoto, N., Kato, M., Sanada, M., Maeshima, A. M., Taniguchi, H., Hosoda, F., Asakura, Y., Munakata, W., Sekiguchi, N., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-457 · Cited by 35
Emerging Complexity of Protein Ubiquitination in the NF- B Pathway
Habelhah, H. (2010) · Genes & Cancer · doi:10.1177/1947601910382900 · Cited by 36
Influence of molecular genetics in Vogt-Koyanagi-Harada disease
Ng, J. Y., Luk, F. O. J., Lai, T. Y. Y., & Pang, C. (2014) · Journal of Ophthalmic Inflammation and Infection · doi:10.1186/s12348-014-0020-1 · Cited by 37
Lawless, D., Pathak, S., Scambler, T., Ouboussad, L., Anwar, R., & Savic, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01527 · Cited by 35
Hereditary systemic autoinflammatory diseases and Schnitzler’s syndrome
Kačar, M., Pathak, S., & Savic, S. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez448 · Cited by 35
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage
Rusu, I., Mennillo, E., Li, Z., Bain, J. L., Sun, X., Ly, K., Rosli, Y. Y., Naser, M., Wang, Z., Advincula, R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci154993 · Cited by 37
Self-citationZanella, F., dos Santos, N. R., & Link, W. (2012) · Traffic · doi:10.1111/tra.12034 · Cited by 35
Matussek, A., Strindhall, J., Stark, L., Rohde, M., Geffers, R., Buer, J., Kihlström, E., Lindgren, P., & Löfgren, S. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2005.01597.x · Cited by 35
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Kawasaki, A., Ito, I., Ito, S., Hayashi, T., Goto, D., Matsumoto, I., Takasaki, Y., Hashimoto, H., Sumida, T., & Tsuchiya, N. (2010) · BioMed Research International · doi:10.1155/2010/207578 · Cited by 35
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Mocchegiani, E., Giacconi, R., Cipriano, C., Gasparini, N., Orlando, F., Stecconi, R., Muzzioli, M., Isani, G., & Carpenè, E. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00414-6 · Cited by 35
Chen, S., Wang, Q., Wu, Z., Li, Y., Li, P., Sun, F., Zheng, W., Wu, Q., Wu, C., 邓垂文, et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110044 · Cited by 34
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Li, M., Shi, X., Qian, T., Li, J., Tian, Z., Ni, B., & Hao, F. (2015) · PubMed Central · Cited by 34
Metadata
- Authors
- Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Lee, Eric G.
- Boone, David L.
- Ma, Averil
- Venue
- Science
- Published
- 2000-09-29
- Volume
- 289
- Issue
- 5488
- Pages
- 2350-2354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3582399
- OpenAlex
- W1993936200
- Cited by
- 1,409
- References
- 19
- Citations by year
- 2026: 21 · 2025: 27 · 2024: 43 · 2023: 33 · 2022: 44 · 2021: 53 · 2020: 57 · 2019: 65 · 2018: 46 · 2017: 68 · 2016: 75 · 2015: 76 · 2014: 72 · 2013: 88 · 2012: 69
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007183, 5T32 GM-07183, T32GM007839, T32GM07839)
- National Institute of Allergy and Infectious Diseases (R01AI045860)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK052751)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- A20, NF-κB, TNF-α, programmed cell death, TNF-induced cell death, inflammation, cachexia, zinc finger proteins
- MeSH terms
- NF-KappaB Inhibitor alpha, Tumor Necrosis Factor alpha-Induced Protein 3, Animals, Cachexia, Cells, Cultured, Cysteine Endopeptidases, DNA, DNA-Binding Proteins, Fibroblasts, Inflammation, Interleukin-1, Intestines, Kidney, Lipopolysaccharides, Liver, Nuclear Proteins, Phosphorylation, Proteins, Skin, T-Lymphocytes, Tumor Necrosis Factor-alpha, NF-kappa B, Zinc Fingers, Apoptosis, Gene Targeting, I-kappa B Proteins, Intracellular Signaling Peptides and Proteins, Mice
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