Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation.

Wang, C.-Y., Mayo, M., Korneluk, R., Goeddel, D., & Baldwin, A. (1998) · Science · doi:10.1126/science.281.5383.1680 · Cited by 2,950

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

Wang, C.-Y., Mayo, M. W., & Baldwin, A. S. (1996) · Science · doi:10.1126/science.274.5288.784 · Cited by 2,586

Suppression of TNF-α-Induced Apoptosis by NF-κB

Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

Sun, S., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993) · Science · doi:10.1126/science.8096091 · Cited by 1,108

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph, D., Yeh, W., Wakeham, A. C., Rudolph, B., Nallainathan, D., Potter, J., Elia, A., & Mak, T. W. (2000) · PubMed Central · Cited by 518

Severe liver degeneration and lack of NF-κ B activation in NEMO/IKKγ-deficient mice

Rudolph, D., Yeh, W.-C., Wakeham, A., Rudolph, B., Nallainathan, D., Potter, J., Elia, A. J., & Mak, T. W. (2000) · Genes & Development · doi:10.1101/gad.14.7.854 · Cited by 479

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.Preprint

Beg, A. A., Sha, W. C., Bronson, R. T., & Baltimore, D. (1995) · Genes & Development · doi:10.1101/gad.9.22.2736 · Cited by 466

Recruitment of the IKK Signalosome to the p55 TNF Receptor

Zhang, S. Q., Kovalenko, A., Cantarella, G., & Wallach, D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80183-1 · Cited by 456

Caspase family in autoimmune diseases

Zhang, W., Wu, H., Liao, Y., Zhu, C., & Zou, Z. (2024) · Autoimmunity Reviews · doi:10.1016/j.autrev.2024.103714 · Cited by 28

HCV Infection and B-Cell Lymphomagenesis

Ito, M., Kusunoki, H., Mochida, K., Yamaguchi, K., & Mizuochi, T. (2011) · Advances in Hematology · doi:10.1155/2011/835314 · Cited by 24

Low Protein A20 in Minor Salivary Glands is Associated with Lymphoma in Primary Sjögren's Syndrome

Johnsen, S. J. A., Gudlaugsson, E. G., Skaland, I., Janssen, E. A. M., Jonsson, M. V., Helgeland, L., Berget, E., Jonsson, R., & Omdal, R. (2015) · Scandinavian Journal of Immunology · doi:10.1111/sji.12405 · Cited by 24

A20 Attenuates Liver Fibrosis in NAFLD and Inhibits Inflammation Responses

Wang, X., Ai, L., Xu, Q., Wu, C. W., Chen, Z., Su, D., Jiang, X., & Fan, Z. (2017) · Inflammation · doi:10.1007/s10753-017-0528-2 · Cited by 24

Immune Differentiation Regulator p100 Tunes NF-κB Responses to TNF

Chatterjee, B., Roy, P., Sarkar, U. A., Zhao, M., Ratra, Y., Singh, A., Chawla, M., De, S., Gomes, J., Sen, R., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00997 · Cited by 23

High A20 expression negatively impacts survival in patients with breast cancer

Yoon, C. I., Ahn, S. G., Bae, S. J., Shin, Y. J., Cha, C., Park, S., Lee, J.-H., Ooshima, A., Lee, H. S., Yang, K., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221721 · Cited by 24

The miR-23a∼27a∼24-2 microRNA Cluster Promotes Inflammatory Polarization of Macrophages

Boucher, A. C., Klopfenstein, N., Hallas, W. M., Skibbe, J. R., Appert, A., Jang, S. H., Pulakanti, K., Rao, S., Dahl, K. D. C., & Dahl, R. E. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901277 · Cited by 23

Deubiquitinases in cell death and inflammation

Newton, K., & Gitlin, A. D. (2022) · Biochemical Journal · doi:10.1042/bcj20210735 · Cited by 26

The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis

Fan, Y., Tao, J., Zhang, L., Li, L.-H., & Ye, D. (2011) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2010.00990.x · Cited by 24

Polymorphisms of the TNFAIP3 region and Graves' disease

Song, R., Yu, Z.-Y., Wang, Q., Muhali, F.-S., Jiang, W., Xiao, L., Shi, X., He, S., Xu, J., & Zhang, J. (2014) · Autoimmunity · doi:10.3109/08916934.2014.914504 · Cited by 24

Spatio-temporal protein dynamics in single living cells

Ankers, J., Spiller, D. G., White, M., & Harper, C. V. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.07.001 · Cited by 25

A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation

Chu, Y., Soberon, V., Glockner, L., Beyaert, R., Massoumi, R., Loo, G., Krappmann, D., & Schmidt‐Supprian, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200396 · Cited by 24

REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY

Lynch, J. P., Metz, D. C., Schuppan, D., Junker, Y., & Barisani, D. (2009) · Cited by 24

Identification of Immune-Responsive Gene 1 (IRG1) as a Target of A20

Quickelberghe, E. V., Martens, A., Goeminne, L. J. E., Clement, L., Loo, G., & Gevaert, K. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00139 · Cited by 25

Protective Genes in the Vessel Wall: Modulators of Graft Survival and Function

Ferran, C. J. (2006) · Transplantation · doi:10.1097/01.tp.0000231445.62162.d5 · Cited by 24

Gene-expression profiles of peripheral blood mononuclear cell subpopulations in acute graft-vs-host disease following cord blood transplantation

Takahashi, N., Sato, N., Takahashi, S., & Tojo, A. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.07.007 · Cited by 24

Indole-3-Carbinol Induces Apoptosis of Hepatic Stellate Cells through K63 De-Ubiquitination of RIP1 in Rats

Li, B., Meng, C., Zhu, Y., Xiong, Y., Jin, W., Wan, Y., Zhou, Y., Ao, Y., & Wang, H. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000470650 · Cited by 24

Proinflammatory Cytokines and Signaling Pathways in Intestinal Innate Immune Cells

Sartor, R. B., & Hoentjen, F. (2005) · Elsevier eBooks · doi:10.1016/b978-012491543-5/50039-5 · Cited by 24

A new role for the anti-apoptotic gene A20 in angiogenesis

Chng, H. W., Camplejohn, R. S., Stone, M. G., Hart, I. R., & Nicholson, L. J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.05.015 · Cited by 24

Role of post-translational modifications of HTLV-1 Tax in NF-κB activation

Shembade, N. (2010) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v1.i1.13 · Cited by 25

Downregulation of A20 Expression Increases the Immune Response and Apoptosis and Reduces Virus Production in Cells Infected by the Human Respiratory Syncytial Virus

Martin‐Vicente, M., González-Sanz, R., Cuesta, I., Monzón, S., Resino, S., & Martínez, I. (2020) · Vaccines · doi:10.3390/vaccines8010100 · Cited by 23

A20 Restricts Inflammatory Response and Desensitizes Gingival Keratinocytes to Apoptosis

Li, Y., Mooney, E. C., Xia, X., Gupta, N., & Sahingur, S. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00365 · Cited by 24

Understanding the Complexity of Sjögren’s Syndrome: Remarkable Progress in Elucidating NF-κB Mechanisms

Sisto, M., Ribatti, D., & Lisi, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092821 · Cited by 23

Chronic hepatic involvement in the clinical spectrum of A20 haploinsufficiency

Deshayes, S., Bazille, C., Khouri, E. E., Koné‐Paut, I., Giurgea, I., Georgin‐Lavialle, S., Silva, N. M., Dumont, A., Ollivier‐Hourmand, I., Amselem, S., et al. (2021) · Liver International · doi:10.1111/liv.14935 · Cited by 23

Advances in the Study of the Ubiquitin-Editing Enzyme A20

Bai, W., Huo, S., Li, J., & Shao, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.845262 · Cited by 25

A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi’s sarcoma-associated herpesvirus vFLIP oncoprotein

Sakakibara, S., Espígol‐Frigolé, G., Gasperini, P., Uldrick, T. S., Yarchoan, R., & Tosato, G. (2012) · Oncogene · doi:10.1038/onc.2012.145 · Cited by 23

Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population

Zhang, X., Li, W., Zhang, X., Zhao, L., Zhang, J., Liang, Z., Guo, Y., Zhang, J., Liang, Z., & Wang, X. (2014) · BMC Medical Genetics · doi:10.1186/1471-2350-15-56 · Cited by 23

Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells

Hong, B., Song, X., Rollins, L. A., Berry, L., Huang, X. F., & Chen, S. Y. (2011) · Journal of Clinical Investigation · doi:10.1172/jci42656 · Cited by 23

Computation and measurement of cell decision making errors using single cell data

Habibi, I., Cheong, R., Lipniacki, T., Levchenko, A., Emamian, E. S., & Abdi, A. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005436 · Cited by 23

Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas

Orlova, A., Wingelhofer, B., Neubauer, H. A., Maurer, B., Berger‐Becvar, A., Keserű, G. M., Gunning, P. T., Valent, P., & Moriggl, R. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1406924 · Cited by 22

A20 of nucleus pulposus cells plays a self-protection role via the nuclear factor-kappa B pathway in the inflammatory microenvironment

Peng, X., Zhang, C., Bao, J.-P., Zhu, L., Shi, R. H., Xie, Z., Wang, F., Wang, K., & Wu, X. (2020) · Bone and Joint Research · doi:10.1302/2046-3758.95.bjr-2019-0230.r1 · Cited by 23

Haploinsufficiency of A20 and other paediatric inflammatory disorders with mucosal involvement

Aeschlimann, F. A., & Laxer, R. M. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000532 · Cited by 23

The Promyelocytic Leukemia Protein Represses A20-mediated Transcription

Wu, W.-S., Xu, Z., & Chang, K.-S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201648200 · Cited by 23

Association of the co-stimulator OX40L with systemic lupus erythematosus

Manku, H., Graham, D. S. C., & Vyse, T. J. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0431-2 · Cited by 23

Cytoprotective pathways in the vascular endothelium. Do they represent a viable therapeutic target?

Mason, J. C. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.08.002 · Cited by 22

A20 attenuates hypoxia-induced pulmonary arterial hypertension by inhibiting NF-κB activation and pulmonary artery smooth muscle cell proliferation

Chen, M., Ding, Z., Zhang, F., Shen, H., Zhu, L., Yang, H., & Chen, S. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.111982 · Cited by 22

TNFAIP3 Plays a Role in Aging of the Hematopoietic System

Smith, M. A., Culver‐Cochran, A. E., Adelman, E. R., Rhyasen, G. W., Ma, A. I., Figueroa, M. E., & Starczynowski, D. T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.536442 · Cited by 20

The roles of immune cells in Behçet’s disease

Hu, D., & Guan, J. (2023) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-023-00328-w · Cited by 22

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration

Studer, P., da Silva, C. G., Revuelta‐Cervantes, J., Mele, A. A., Csizmadia, E., Siracuse, J. J., Damrauer, S. M., Peterson, C. R., Candinas, D., Stroka, D., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.52 · Cited by 22

Microbes and microbial effector molecules in treatment of inflammatory disorders

Kelly, D., Delday, M. I., & Mulder, I. E. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01079.x · Cited by 23

Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain

Pranski, E. L., Sanford, C. V., Dalal, N. V., Orr, A. L., Karmali, D., Cooper, D. S., Costa, N., Heilman, C. J., Gearing, M., Lah, J. J., et al. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.043 · Cited by 22

HSCARG inhibits activation of NF-κB by interacting with IκB kinase-β

Gan, Q., Li, T., Hu, B., Lian, M., & Zheng, X. (2009) · Journal of Cell Science · doi:10.1242/jcs.054007 · Cited by 22

Tumor necrosis factor and lymphotoxin in regulation of intestinal inflammation

Gubernatorova, E. O., & Tumanov, A. V. (2016) · Biochemistry (Moscow) · doi:10.1134/s0006297916110092 · Cited by 22

Hypomorphic A20 expression confers susceptibility to psoriasis

Aki, A., Nagasaki, M., Malynn, B. A., Ma, A. I., & Kagari, T. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180481 · Cited by 22

Mathematical Modeling and Parameter Estimation of Intracellular Signaling Pathway: Application to LPS-induced NFκB Activation and TNFα Production in Macrophages

Lee, D., Ding, Y., Jayaraman, A., & Kwon, J. S. (2018) · Processes · doi:10.3390/pr6030021 · Cited by 21

Case Report: A Novel TNFAIP3 Mutation Causing Haploinsufficiency of A20 With a Lupus-Like Phenotype

Shaheen, Z. R., Williams, S. J. A., & Binstadt, B. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.629457 · Cited by 22

A20/Nrdp1 interaction alters the inflammatory signaling profile by mediating K48- and K63-linked polyubiquitination of effectors MyD88 and TBK1

Meng, Z., Xu, R., Xie, L., Wu, Y., He, Q., Gao, P., He, X., Chen, Q., Xie, Q., Zhang, J., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100811 · Cited by 21

Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium

Kelly, C., Williams, M. T. S., Mitchell, K., Elborn, J. S., Ennis, M., & Schock, B. C. (2012) · European Respiratory Journal · doi:10.1183/09031936.00032412 · Cited by 22

Sensitivity Analysis of a Computational Model of the IKK–NF‐κB–IκBα–A20 Signal Transduction Network

JOO, J., PLIMPTON, S., MARTIN, S., SWILER, L., & Faulon, J. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1407.014 · Cited by 22

Low TNFAIP3 expression in psoriatic skin promotes disease susceptibility and severity

Sahloul, N. Y., Mostafa, M. S., Madkour, L. A. E.-F., & Salama, D. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217352 · Cited by 21

The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation

Ullah, F., Gamage, R. V., Sen, M. K., & Gyengési, E. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03499-4 · Cited by 21

Tunicamycin Protects against LPS-Induced Lung Injury

Kubra, K., Uddin, M. A., & Barabutis, N. (2022) · Pharmaceuticals · doi:10.3390/ph15020134 · Cited by 21

Emergence of the A20/ABIN-mediated inhibition of NF-κB signaling via modifying the ubiquitinated proteins in a basal chordate

Yuan, S., Dong, X., Tao, X., Xu, L., Ruan, J., Peng, J., & Xu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321187111 · Cited by 21

Hepatocyte growth factor preferentially activates the anti‐inflammatory arm of NF‐κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation

da Silva, C. G., Maccariello, E. R., Wilson, S., Putheti, P., Daniel, S., Damrauer, S. M., Peterson, C. R., Siracuse, J. J., Kaczmarek, E., & Ferran, C. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22851 · Cited by 21

Dendritic Cell-Based Immunotherapy for Glioma: Multiple Regimens and Implications in Clinical Trials

Mineharu, Y., Castro, M. G., Lowenstein, P. R., Sakai, N., & Miyamoto, S. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.ra2013-0234 · Cited by 21

Regulatory roles of tumor necrosis factor alpha-induced proteins (TNFAIPs) 3 and 9 in arthritis

Matsumoto, I., Inoue, A., Takai, C., Umeda, N., Tanaka, Y., Kurashima, Y., & Sumida, T. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.015 · Cited by 21

Lysine 63-linked Ubiquitination Modulates Mixed Lineage Kinase-3 Interaction with JIP1 Scaffold Protein in Cytokine-induced Pancreatic β Cell Death

Humphrey, R. K., Yu, S. M. A., Bellary, A., Gonuguntla, S., Yebra, M., & Jhala, U. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425884 · Cited by 21

Inflammation-induced airway smooth muscle responsiveness is strain dependent in mice

Säfholm, J., Lövdahl, C., Swedin, L., Boels, P. J. M., Dahlén, S., Arner, A., & Mikael Adner, A. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.01.001 · Cited by 21

Inhibition of A20 expression in tumor microenvironment exerts anti-tumor effect through inducing myeloid-derived suppressor cells apoptosis

Shao, B., Wei, X., Luo, M., Yu, J., Tong, A., Ma, X., Ye, T., Deng, H., Sang, Y., Liang, X., et al. (2015) · Scientific Reports · doi:10.1038/srep16437 · Cited by 22

A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis

Ai, L., Xu, Q., Wu, C. W., Wang, X., Chen, Z., Su, D., Jiang, X., Xu, A., Lin, Q., & Fan, Z. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13371 · Cited by 21

A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes

Lappas, M. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax041 · Cited by 21

A20/TNFAIP3 Discriminates Tumor Necrosis Factor (TNF)-Induced NF-κB from JNK Pathway Activation in Hepatocytes

Pinna, F., Bissinger, M., Beuke, K., Huber, N., Longerich, T., Kummer, U., Schirmacher, P., Sahle, S., & Breuhahn, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00610 · Cited by 21

Dynamic Protein Complexes Regulate NF-κB Signaling

Wegener, E., & Krappmann, D. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72843-6_10 · Cited by 21

Literature-related discovery: common factors for Parkinson’s Disease and Crohn’s Disease

Kostoff, R. N. (2014) · Scientometrics · doi:10.1007/s11192-014-1298-3 · Cited by 21

Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling

Lee, F. F.-Y., & Alper, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1023567 · Cited by 23

Ubiquitylation and autophagy in the control of bacterial infections and related inflammatory responses

Ligeon, L., Temime‐Smaali, N., & Lafont, F. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01628.x · Cited by 24

PACAP-cytokine interactions govern adrenal neuropeptide biosynthesis after systemic administration of LPS

Aït‐Ali, D., Stroth, N., Sen, J. M., & Eiden, L. E. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.034 · Cited by 20

The deubiquitinase A20 in immunopathology of autoimmune diseases

Majumdar, I., & Paul, J. (2014) · Autoimmunity · doi:10.3109/08916934.2014.900756 · Cited by 20

Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice

Murphy, S. F., Rhee, L., Grimm, W. A., Weber, C. R., Messer, J. S., Lodolce, J. P., Chang, J. E., Bartulis, S. J., Nero, T. M., Kukla, R. A., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00020.2014 · Cited by 21

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma

Bu, R., Bavi, P. P., Abubaker, J. A., Jehan, Z., Al‐Haqawi, W., Ajarim, D. S., Al‐Dayel, F., Shahab Uddin, M. S., & Al-Kuraya, K. S. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.668286 · Cited by 20

Quantitative characterization and analysis of the dynamic NF-κB response in microglia

Sheppard, P. W., Sun, X., Emery, J. F., Giffard, R. G., & Khammash, M. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-276 · Cited by 19

Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase

Perez, J. M., Chen, Y., Xiao, T. S., & Abbott, D. W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000408 · Cited by 20

Gene-function studies in systemic lupus erythematosus

Rosetti, F., de la Cruz, A., & Crispín, J. C. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000572 · Cited by 20

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

Feoktistova, M., Makarov, R., Brenji, S., Schneider, A. T., Hooiveld, G. J. E. J., Luedde, T., Leverkus, M., Yazdi, A. S., & Panayotova‐Dimitrova, D. (2020) · Cells · doi:10.3390/cells9020351 · Cited by 19

Single-cell time-lapse imaging of the dynamic control of NF-κB signalling

Sillitoe, K., Horton, C. A., Spiller, D. G., & White, M. (2007) · Biochemical Society Transactions · doi:10.1042/bst0350263 · Cited by 19

Associations Between TNFAIP3 Gene Polymorphisms and Systemic Lupus Erythematosus: A Meta-Analysis

Lee, Y. H., & Song, G. G. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0096 · Cited by 20

Identification of the NF-κB inhibitor A20 as a key regulator for human adipogenesis

Dorronsoro, A., Lang, V., Jakobsson, E., Ferrin, I., Salcedo, J. M., Fernández‐Rueda, J., Fechter, K., Rodriguez, M. S., & Trigueros, C. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.494 · Cited by 20

RNF11, a new piece in the A20 puzzle

Jacque, É., & Ley, S. C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.18 · Cited by 20

Rare variants, autoimmune disease, and arthritis

Chung, S. A., & Shum, A. K. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000298 · Cited by 19

Ubiquitin Protein Modification and Signal Transduction: Implications for Inflammatory Bowel Diseases

Taylor, C. T., & Jobin, C. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000187577.26043.e5 · Cited by 20

Ref-1 and Transcriptional Control of Endothelial Apoptosis

Wang, N., & Stemerman, M. B. (2001) · Circulation Research · doi:10.1161/hh1201.093162 · Cited by 20

Herbs-partitioned moxibustion improves intestinal epithelial tight junctions by upregulating A20 expression in a mouse model of Crohn’s disease

Shi, Y., Guo, Y., Zhou, J., Wu, L., Chen, L., Sun, Y., Li, T., Zhao, J., Bao, C., & Wu, H. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109149 · Cited by 18

The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?

Zou, M., Zeng, Q., Nie, J., Yang, J., Luo, Z.-Y., & Gan, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.769167 · Cited by 19

Fibroblast A20 governs fibrosis susceptibility and its repression by DREAM promotes fibrosis in multiple organs

Wang, W., Bale, S., Wei, J., Yalavarthi, B., Bhattacharyya, D., Yan, J. J., Abdala‐Valencia, H., Xu, D., Sun, H., Marangoni, R. G., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33767-y · Cited by 21

A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny

Rohwedder, I., Wackerbarth, L. M., Heinig, K., Ballweg, A., Altstätter, J., Ripphahn, M., Nußbaum, C., Salvermoser, M., Bierschenk, S., Straub, T., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.155968 · Cited by 19

The impact of the cytoplasmic ubiquitin ligase TNFAIP3 gene variation on transcription factor NF-κB activation in acute kidney injury

Rogers, N. M., Zammit, N. W., Nguyen-Ngo, D., Souilmi, Y., Minhas, N., Meijles, D. N., Self, E., Walters, S. N., Warren, J. A., Cultrone, D., et al. (2023) · Kidney International · doi:10.1016/j.kint.2023.02.030 · Cited by 19

A20-An Omnipotent Protein in the Liver: Prometheus Myth Resolved?

da Silva, C. G., Revuelta‐Cervantes, J., Studer, P., & Ferran, C. J. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_8 · Cited by 20

A20 is a regulator of necroptosis

Gurung, P., Man, S. M., & Kanneganti, T. (2015) · Nature Immunology · doi:10.1038/ni.3174 · Cited by 19

A20 targets caspase-8 and FADD to protect HTLV-I-infected cells

Saitoh, Y., Hamano, A., Mochida, K., Kakeya, A., Uno, M., Tsuruyama, E., Ichikawa, H., Tokunaga, F., Utsunomiya, A., Watanabe, T., et al. (2015) · Leukemia · doi:10.1038/leu.2015.267 · Cited by 19

B-Cell-Intrinsic Hepatitis C Virus Expression Leads to B-Cell-Lymphomagenesis and Induction of NF-κB Signalling

Kasama, Y., Mizukami, T., Kusunoki, H., Peveling‐Oberhag, J., Nishito, Y., Ozawa, M., Kohara, M., Mizuochi, T., & Tsukiyama–Kohara, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091373 · Cited by 19

Clustering reveals limits of parameter identifiability in multi-parameter models of biochemical dynamics

Nienałtowski, K., Włodarczyk, M., Tomasz Lipniacki, B., & Komorowski, M. (2015) · BMC Systems Biology · doi:10.1186/s12918-015-0205-8 · Cited by 19

A20 regulates IL-1-induced tolerant production of CXC chemokines in human mesangial cells via inhibition of MAPK signaling

Luo, H. R., Liu, Y., Li, Q., Liao, L., Sun, R., Liu, X., Jiang, M., & Hu, J. (2015) · Scientific Reports · doi:10.1038/srep18007 · Cited by 19

Attenuated JNK signaling in multidrug-resistant leukemic cells. Dual role of MAPK in cell survival

Cerezo, D., Ruiz‐Alcaraz, A. J., Lencina, M., Cánovas, M., García–Peñarrubia, P., Martínez-López, I., & Martín‐Orozco, E. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.12.003 · Cited by 19

TNF phase III signalling in tolerant cells is tightly controlled by A20 and CYLD

Bikker, R., Christmann, M., Preuß, K., Welz, B., Friesenhagen, J., Dittrich‐Breiholz, O., Huber, R., & Brand, K. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.06.009 · Cited by 18

Electroacupuncture Pretreatment Alleviates LPS‐Induced Acute Respiratory Distress Syndrome via Regulating the PPAR Gamma/NF‐Kappa B Signaling Pathway

Feng, D., Zhou, H., Jin, X., Wei, J., Zhang, Q., Gu, Y., Zhang, P., Yang, H., Song, J., Shi, X., et al. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/4594631 · Cited by 19

Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma

Song, Z., Wei, W., Xiao, W., Al-Saleem, E. D., Nejati, R., Chen, L., Yin, J., Fabrizio, J., Petrus, M. N., Waldmann, T. A., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014470117 · Cited by 19

A20 Inhibits LPS-Induced Inflammation by Regulating TRAF6 Polyubiquitination in Rainbow Trout

Jang, J. H., Kim, H. J., Jung, I. Y., & Cho, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189801 · Cited by 19

Le psoriasis : physiopathologie et immunogénétique

Ammar, M., Souissi-Bouchlaka, C., Gati, A., Zarâa, I., Bouhaha, R., Kouidhi, S., Ammar-Gaied, A. B., Doss, N., Mokni, M., & Marrakchi, R. (2013) · Pathologie Biologie · doi:10.1016/j.patbio.2013.07.014 · Cited by 24

The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability

Ceregido, M. A., Spínola‐Amilibia, M., Buts, L., Rivera, J., Garcia‐Pino, A., Bravo, J., & van Nuland, N. A. J. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.11.006 · Cited by 19

A20 and cell death-driven inflammation

Priem, D., van Loo, G., & Bertrand, M. J. M. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.001 · Cited by 139

A20 at the Crossroads of Cell Death, Inflammation, and AutoimmunityPreprint

Martens, A., & Loo, G. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036418 · Cited by 142

A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death in keratinocytes

Panayotova‐Dimitrova, D., & Feoktistova, M. (2019) · doi:10.26226/morressier.5d4980cf8fb7e44098e72fd2

A20 and A20-binding proteins as cellular inhibitors of nuclear factor-κB-dependent gene expression and apoptosis

Beyaert, R., Heyninck, K., & Huffel, S. V. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00404-4 · Cited by 302

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295