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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Abstract
The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the β protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the β protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.
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“Importantly, sequence differences between mice and humans include 3 amino acids within the Aβ sequence (R5G, Y10F and H13R)[155, 174].”
From Alzheimer's disease: experimental models and reality (2017) · cites this paper as [155]
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Metadata
- Authors
- Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L.
- Venue
- Science
- Published
- 1987-02-20
- Volume
- 235
- Issue
- 4791
- Pages
- 880-884
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2056046302
- Cited by
- 1,611
- References
- 41
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 19 · 2021: 23 · 2020: 33 · 2019: 31 · 2018: 18 · 2017: 27 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 33 · 2012: 34
- FWCI
- 123.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 00029)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 20118, HD10658)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Keywords
- amyloid-beta, APP gene, Alzheimer's disease, Down syndrome, chromosome 21, genetic linkage, gene mapping, cerebrovascular amyloid, amyloid plaques, gene dosage
- MeSH terms
- Alzheimer Disease, Amino Acid Sequence, Amyloid, Amyloidosis, Brain, Chromosome Mapping, Chromosomes, Human, Pair 21, DNA, Down Syndrome, Gene Expression Regulation, Humans, Genetic Linkage, RNA, Messenger, Tissue Distribution, Transcription, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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