Cited by 1,611Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchDown syndrome and intellectual disability research

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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Tanzi, Rudolph E., Gusella, James F., Watkins, Paul C., Bruns, Gail A. P., St George-Hyslop, Peter, Van Keuren, Margaret L., Patterson, David, Pagan, Susan, Kurnit, David M., Neve, Rachael L.·1987·Science

DOI 10.1126/science.2949367

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Abstract

The amyloid β protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the β protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the β protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.

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Authors: Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L.
ORCID: Tanzi, Rudolph E.
Gusella, James F.
Patterson, David
Neve, Rachael L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1987-02-20
Volume: 235
Issue: 4791
Pages: 880-884
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.2949367
OpenAlex: W2056046302
Cited by: 1,611
References: 41
Citations by year: 2026: 13 · 2025: 15 · 2024: 14 · 2023: 22 · 2022: 19 · 2021: 23 · 2020: 33 · 2019: 31 · 2018: 18 · 2017: 27 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 33 · 2012: 34
FWCI: 123.83
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG 00029)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 20118, HD10658)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Keywords: amyloid-beta, APP gene, Alzheimer's disease, Down syndrome, chromosome 21, genetic linkage, gene mapping, cerebrovascular amyloid, amyloid plaques, gene dosage
MeSH terms: Alzheimer Disease, Amino Acid Sequence, Amyloid, Amyloidosis, Brain, Chromosome Mapping, Chromosomes, Human, Pair 21, DNA, Down Syndrome, Gene Expression Regulation, Humans, Genetic Linkage, RNA, Messenger, Tissue Distribution, Transcription, Genetic

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Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

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