Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

Yanisch-Perron, C., Vieira, J., & Messing, J. W. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 14,909

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

Maxam, A. M., & Gilbert, W. (1980) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(80)65059-9 · Cited by 13,943

Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

Botstein, D., White, R. L., Skolnick, M. H., & Davis, R. W. (1980) · Europe PMC (PubMed Central) · Cited by 8,327

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627

Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.

Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268

Efficient isolation of genes by using antibody probes.

Young, R. A., & Davis, R. W. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.5.1194 · Cited by 2,036

Amyloid Deposits and Amyloidosis

Glenner, G. G. (1980) · New England Journal of Medicine · doi:10.1056/nejm198006053022305 · Cited by 1,780

Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus

Vassar, R. J. (2019) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2019.3 · Cited by 32

The Challenging Pathway of Treatment for Neurogenesis Impairment in Down Syndrome: Achievements and Perspectives

Stagni, F., & Bartesaghi, R. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.903729 · Cited by 33

The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment

Ma, F., Akolkar, H., Xu, J., Liu, Y., Popova, D., Xie, J., Youssef, M. M., Benosman, R. B., Hart, R. P., & Herrup, K. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0172-22.2023 · Cited by 33

Power and Pitfalls of the Genome-Wide Association Study Approach to Identify Genes for Alzheimer’s Disease

Sherva, R., & Farrer, L. A. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0184-4 · Cited by 31

Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin‐binding neuroregulatory factors

Umehara, Y., Yamada, S., Nishimura, S., Shioi, J., Robakis, N. K. R. K., & Sugahara, K. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01506-0 · Cited by 31

Novel strategies for Alzheimer's disease treatment

Spencer, B. J., Rockenstein, E. M., Crews, L. A., Marr, R. A., & Masliah, E. (2007) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.7.12.1853 · Cited by 31

Serine proteases and their serpin inhibitors in Alzheimer's disease

Ho, G. J., Smirnova, I. V., Akaaboune, M., Hantaï, D., & Festoff, B. W. (1994) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(94)90175-9 · Cited by 31

In vitro synaptotrophic effects of Cerebrolysin in NT2N cells

Mallory, M. E., Honer, W. G., Hsu, L. J., Johnson, R., Rockenstein, E. M., & Masliah, E. (1999) · Acta Neuropathologica · doi:10.1007/s004010051012 · Cited by 31

β A4 amyloid protein and its precursor in Alzheimer's disease

Bush, A. I., Beyreuther, K. T., & Masters, C. L. (1992) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(92)90039-3 · Cited by 32

The molecular genetics of Alzheimer's disease

MULLAN, M. J., & Crawford, F. (1994) · Molecular Neurobiology · doi:10.1007/bf02816100 · Cited by 32

Determination of RNA content in postischemic gerbil brain byin situ hybridization

Xie, Y., Herget, T., Hallmayer, J. F., Starzinski‐Powitz, A., & Hossmann, K. A. (1989) · Metabolic Brain Disease · doi:10.1007/bf00999770 · Cited by 31

The processing of Alzheimer A4/β-amyloid protein precursor: Identification of a human brain metallopeptidase which cleaves -Lys-Leu- in a model peptide

MCDERMOTT, J. R., & GIBSON, A. M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91691-5 · Cited by 31

Down's syndrome and the molecular biology of chromosome 21

Cooper, D. N., & Hall, C. (1988) · Progress in Neurobiology · doi:10.1016/0301-0082(88)90033-0 · Cited by 31

The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

Moll, L., & Schubert, M. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/384094 · Cited by 31

Expression of amyloid precursor protein‐like molecule in astroglial cells of the subventricular zone and rostral migratory stream of the adult rat forebrain

Yasuoka, K., Hirata, K., Kuraoka, A., He, J., & Kawabuchi, M. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00320.x · Cited by 30

Overexpression of genes in health and sickness. A bird's eye view

Shastry, B. S. (1995) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/0305-0491(95)00055-d · Cited by 30

Ex Situ Atomic Force Microscopy Analysis of β-Amyloid Self-Assembly and Deposition on a Synthetic Template

Ha, C., & Park, C. B. (2006) · Langmuir · doi:10.1021/la0601511 · Cited by 30

Anti-IL17 treatment ameliorates Down syndrome phenotypes in mice

Rueda, N., Vidal, V., García-Cerro, S., Narcís, J. O., Llorens-Martı́n, M., Corrales, A., Lantigua, S., Iglesias, M., Merino, J., Merino, R., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.05.008 · Cited by 31

Genetics and psychiatry: past discoveries, current dilemmas, and future directions

Pardes, H., Kaufmann, C. A., Pincus, H. A., & West, A. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.4.435 · Cited by 30

Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration.

Galimberti, D., & Scarpini, E. A. (2010) · PubMed Central · Cited by 29

Mobile phone electromagnetic radiation affects Amyloid Precursor Protein and α-synuclein metabolism in SH-SY5Y cells

Stefi, A. L., Margaritis, L. H., Skouroliakou, A., & Vassilacopoulou, D. (2019) · Pathophysiology · doi:10.1016/j.pathophys.2019.02.004 · Cited by 29

Upregulation of Alzheimer’s Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo

Liang, Y., Raven, F., Ward, J. F., Zhen, S. Y., Zhang, S., Sun, H., Miller, S., Choi, S. H., Tanzi, R. E., & Zhang, C. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200128 · Cited by 29

N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly

Liao, M.-C., Hoos, M. D., Aucoin, D., Ahmed, M., Davis, J., Smith, S. O., & Nostrand, W. E. V. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169599 · Cited by 29

In search of genes involved in neurodegenerative disorders

Pardo, L. M., & van Duijn, C. M. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.006 · Cited by 30

Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target

Padovani, A., Borroni, B., Colciaghi, F., Pastorino, L., Archetti, S., Cottini, E., Caimi, L., Cattabeni, F., & Luca, M. D. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00315-3 · Cited by 30

Genetic study of familial cases of Alzheimer's disease.

Kowalska, A., Pruchnik-Wolinska, D., Florczak, J., Modestowicz, R., Szczech, J., Kozubski, W. P., Rossa, G., & Wender, M. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3617 · Cited by 31

Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751

Liu, F. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00152-6 · Cited by 29

Characterization of Alzheimer amyloid precursor protein transcripts in platelets and megakarocytes

Gardella, J. E., Gorgone, G., Newman, P. J., Frangione, B., & Gorevic, P. D. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90921-s · Cited by 29

A Two Decade Contribution of Molecular Cell Biology to the Centennial of Alzheimer's Disease: Are We Progressing Toward Therapy?

Dillen, K., & Annaert, W. G. (2006) · International review of cytology · doi:10.1016/s0074-7696(06)54005-7 · Cited by 29

The Role of the Amyloid Protein Precursor (APP) in Alzheimer's Disease: Does the Normal Function of APP Explain the Topography of Neurodegeneration?

Small, D. H. (1998) · Neurochemical Research · doi:10.1023/a:1022471729291 · Cited by 30

Effects of the amyloid protein precursor of Alzheimer's disease and other ligands of the LDL receptor‐related protein on neurite outgrowth from sympathetic neurons in culture

Postuma, R. B., Martins, R. N., Cappai, R., Beyreuther, K., Masters, C. L., Strickland, D. K., Mok, S. S., & Small, D. H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00475-x · Cited by 29

Normal Processing of the Alzheimer's Disease Amyloid β Protein Precursor Generates Potentially Amyloidogenic Carboxyl‐Terminal Derivatives

Estus, S., Golde, T. E., & Younkin, S. G. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27483.x · Cited by 29

Location cloning strategy for characterizing genetic defects in Huntington's disease and Alzheimer's disease

Gusella, J. F. (1989) · The FASEB Journal · doi:10.1096/fasebj.3.9.2568302 · Cited by 29

The Involvement of Proteases, Protease Inhibitors, and an Acute Phase Response in Alzheimer's Disease a

Potter, H., Nelson, R. B., Das, S., Siman, R. G., Kayyali, U. S., & Dressler, D. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb27485.x · Cited by 29

Seven polymorphic loci mapping to human chromosomal region 11q22-qter

Maslen, C. L., Jones, C., Glaser, T., Magenis, R. E., Sheehy, R. R., Kellogg, J. A., & Litt, M. J. (1988) · Genomics · doi:10.1016/0888-7543(88)90110-3 · Cited by 29

Alzheimer's Disease as an Age‐Dependent Disorder

Katzman, R. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513583.ch6 · Cited by 29

Is It the Twilight of BACE1 Inhibitors?

Hrabinova, M., Pejchal, J., Kucera, T., Jun, D., Schmidt, M., & Soukup, O. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200503023323 · Cited by 28

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s Disease

Xia, Q., Yang, X., Shi, J., Liu, Z., Peng, Y., Wang, W., Li, B., Zhao, Y., Xiao, J., Huang, L. F., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02385-y · Cited by 32

The Amyloid Cascade Hypothesis 2.0 for Alzheimer’s Disease and Aging-Associated Cognitive Decline: From Molecular Basis to Effective Therapy

Volloch, V., & Rits‐Volloch, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512246 · Cited by 29

Tol2 gene trap integrations in the zebrafish amyloid precursor protein genes appa and aplp2 reveal accumulation of secreted APP at the embryonic veins

Liao, H., Wang, Y., Watt, K. E. N., Wen, Q., Breitbach, J. T., Kemmet, C. K., Clark, K. J., Ekker, S. C., Essner, J. J., & McGrail, M. A. (2011) · Developmental Dynamics · doi:10.1002/dvdy.23725 · Cited by 28

Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype

Morelli, L., Wei, L., Amorim, A., McDermid, J., Abee, C. R., Frangione, B., Walker, L. C., & Levy, E. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01491-8 · Cited by 30

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains

Johnston, J. A., Norgren, S., Ravid, R., Wasco, W., Winblad, B. G., Lannfelt, L., & Cowburn, R. F. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00161-1 · Cited by 28

Gene identification in Alzheimer’s disease

Saunders, A. M. (2001) · Pharmacogenomics · doi:10.1517/14622416.2.3.239 · Cited by 30

USF binds to the APBα sequence in the promoter of the amyloid β-protein precursor gene

Vostrov, A. A., Quitschke, W. W., Vidal, F., Schwarzman, A. L., & Goldaber, D. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2734 · Cited by 28

Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates

Wagner, S. L., Nostrand, W. E. V., Lau, A., Farrow, J. S., Suzuki, M., Bartus, R. T., Schuppek, R., Nguyen, A., Cotman, C. W., & Cunningham, D. D. (1993) · Brain Research · doi:10.1016/0006-8993(93)90567-7 · Cited by 28

Genetic studies on an Alzheimer Clinic population

Sadovnick, A. D., IRWIN, M. E., Baird, P. A., Beattie, B. L., & Conneally, P. M. (1989) · Genetic Epidemiology · doi:10.1002/gepi.1370060508 · Cited by 28

High molecular weight Alzheimer's disease amyloid peptide immunoreactivity in human serum and CSF is an immunoglobulin G

Pardridge, W. M., Vinters, H. V., Miller, B. L., Tourtellotte, W. W., Eisenberg, J., & Yang, J. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91312-x · Cited by 28

Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells

Huttunen, H. J., Puglielli, L., Ellis, B. C., Ingano, L. A. M., & Kovacs, D. M. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-008-9088-0 · Cited by 27

Analysis of amyloid precursor protein function in Drosophila melanogaster

Poeck, B., Strauß, R., & Kretzschmar, D. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2860-3 · Cited by 29

Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639

Tang, K., Wang, C., Shen, C., Sheng, S., Ravid, R., & Jing, N. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02731.x · Cited by 27

Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP

Fragkouli, A., Koukouraki, P., Vlachos, I. S., Paraskevopoulou, M. D., Hatzigeorgiou, A. G., & Doxakis, E. (2017) · Scientific Reports · doi:10.1038/srep44507 · Cited by 27

Blood‐based biomarkers for Down syndrome and Alzheimer's disease: A systematic review

Petersen, M. E., & O’Bryant, S. E. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22714 · Cited by 27

Alzheimer'S Disease: Advances In Genetics, Molecular And Cellular Biology

Sisodia, S. S., & Tanzi, R. E. (2007) · Cited by 27

Cortical cathepsin D activity and immunolocalization in Alzheimer disease, critical coronary artery disease, and aging

Haas, U., & Sparks, D. L. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815189 · Cited by 27

Dorothy Russell Memorial Lecture The molecular pathology of Alzheimer's disease: are we any closer to understanding the neurodegenerative process?

Smith, C. J., & Anderton, B. H. (1994) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1994.tb00977.x · Cited by 27

A polymorphic DNA marker that represents a conserved expressed sequence in the region of the Huntington disease gene.

Hayden, M. R., Hewitt, J., Wasmuth, J. J., Kastelein, J. J. P., Langlois, S., Conneally, M., Haines, J. L., Smith, B. A., Hilbert, C., & Allard, D. (1988) · Europe PMC (PubMed Central) · Cited by 27

A novel mutation in the ?-protein coding region of the amyloid ?-protein precursor (APP) gene

Balbín, M., Abrahamson, M., Gustafson, L., Nilsson, K. H., Brun, A. E., & GRUBB, A. O. (1992) · Human Genetics · doi:10.1007/bf00219191 · Cited by 27

Genetic Diseases of Premature Aging as Models of Senescence

Brown, W. T. (1991) · Springer eBooks · doi:10.1007/978-3-662-38445-9_2 · Cited by 27

Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain

Nieto, A., de Garcini, E. M., Correas, I., & Ávila, J. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90201-e · Cited by 27

Early-onset Formation of Parenchymal Plaque Amyloid Abrogates Cerebral Microvascular Amyloid Accumulation in Transgenic Mice

Xu, F., Kotarba, A. E., Ou-Yang, M.-H., Fu, Z., Davis, J., Smith, S. O., & Nostrand, W. E. V. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536565 · Cited by 26

Selenium-Derivative Compounds: A Review of New Perspectives in the Treatment of Alzheimer’s Disease

Barbosa, F. A. R., Canto, R. F. S., Teixeira, K. F., de Souza, A. S., de Oliveira, A. S., & Braga, A. L. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220224161454 · Cited by 26

New Genes and New Insights from Old Genes

Ringman, J. M., & Coppola, G. (2013) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000429179.21977.a1 · Cited by 27

Study of the sugar chains of recombinant human amyloid precursor protein produced by Chinese hamster ovary cells

Sato, Y., Liu, C., Wójczyk, B. S., Kobata, A., Spitalnik, S. L., & Endo, T. (1999) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(99)00140-3 · Cited by 26

The amyloid precursor protein gene: a neuropeptide gene with diverse functions in the central nervous system

Panegyres, P. K. (1997) · Neuropeptides · doi:10.1016/s0143-4179(97)90000-7 · Cited by 26

Insertion of the amyloid precursor protein into lipid monolayers: effects of cholesterol and apolipoprotein E

Lahdo, R., & Bessueille, L. (2004) · Biochemical Journal · doi:10.1042/bj20040777 · Cited by 26

Cortico‐hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice

Seo, H., Ferree, A. W., & Ole Isacson, A. (2002) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01884.x · Cited by 26

Presenilins

Checler, F. (1999) · Molecular Neurobiology · doi:10.1007/bf02821716 · Cited by 26

Olfactory Deficits in down Subjects: A Link with Alzheimer Disease

Zucco, G. M., & Saviolo, N. (1994) · Perceptual and Motor Skills · doi:10.2466/pms.1994.78.2.627 · Cited by 26

Astrocytosis, βA4-protein deposition and paired helical filament formation in Alzheimer's disease

Cairns, N. J., Chadwick, A. J., Luthert, P. J., & Lantos, P. L. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90134-7 · Cited by 26

The molecular pathology of amyloid deposition in Alzheimer's disease

Martins, R. N., Robinson, P. J., Chleboun, J. O., Beyreuther, K. T., & Masters, C. L. (1991) · Molecular Neurobiology · doi:10.1007/bf02935560 · Cited by 26

Expression of 'Alzheimer Antigens' in Cultured Skin Fibroblasts

Blass, J. P., Baker, A. C., Ko, L., Sheu, R.-C., & Black, R. S. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530190055016 · Cited by 26

Developmental consequences of autosomal aneuploidy in mammals

Gearhart, J. D., Oster‐Granite, M. L., Reeves, R. H., & Coyle, J. T. (1987) · Developmental Genetics · doi:10.1002/dvg.1020080408 · Cited by 26

Alzheimer’s Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention Trials

Rafii, M. S. (2020) · CNS Drugs · doi:10.1007/s40263-020-00740-6 · Cited by 26

The role of structural variations in Alzheimer’s disease and other neurodegenerative diseases

Wang, H., Wang, L., Schellenberg, G. D., & Lee, W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1073905 · Cited by 28

Infrared spectroscopic analysis of mononuclear leukocytes in peripheral blood from Alzheimer’s disease patients

Carmona, P., Molina, M., Calero, M., Bermejo‐Pareja, F., Martínez‐Martín, P., Álvarez, I., & Tolédano, A. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-011-5669-9 · Cited by 25

Molecular Genetics of Alzheimer's Disease and the Amyloid β Peptide Precursor Gene

Tanzi, R. E. (1989) · Annals of Medicine · doi:10.3109/07853898909149191 · Cited by 25

A chapter in the development of Alzheimer's disease research: A case study of public policies on the development and funding of research programs

Khachaturian, Z. S. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.04.379 · Cited by 25

Alzheimer's disease and control brain contain soluble derivatives of the amyloid protein precursor that end within the .beta. amyloid protein region

Pasternack, J. M., Palmert, M. R., Usiak, M., Wang, R., Zürcher-Neely, H. A., Gonzalez‐DeWhitt, P. A., Fairbanks, M. B., Cheung, T. T., & Blades, D. A. (1992) · Biochemistry · doi:10.1021/bi00159a038 · Cited by 25

Chondroitin sulfate proteoglycan form of cellular and cell-surface Alzheimer amyloid precursor

Shioi, J., Refolo, L. M., Efthimiopoulos, S., & Robakis, N. K. R. K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90186-o · Cited by 25

The Initiator Element and Proximal Upstream Sequences Affect Transcriptional Activity and Start Site Selection in the Amyloid β-Protein Precursor Promoter

Quitschke, W. W., Matthews, J. P., Kraus, R. J., & Vostrov, A. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.22231 · Cited by 25

Cellular and molecular biology of alzheimer's disease

Price, D. L., Koo, E. H., & Unterbeck, A. (1989) · BioEssays · doi:10.1002/bies.950100208 · Cited by 25

Interactions of the alzheimer β amyloid fragment (25–35) with peripheral blood dendritic cells

Schmitt, T. L., Steger, M. M., Pavelka, M., & Grubeck-Loebenstein, B. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)01866-6 · Cited by 25

Chapter 21 Genetics and biology of the Alzheimer amyloid precursor

Neve, R. L., Dawes, L. R., Yankner, B. A., Benowitz, L. I., Rodriguez, W. R., & Higgins, G. A. (1990) · Progress in brain research · doi:10.1016/s0079-6123(08)63182-9 · Cited by 25

Gene mutation defends against Alzheimer’s disease

Callaway, E. (2012) · Nature · doi:10.1038/487153a · Cited by 25

Studies on the first described Alzheimer's disease amyloid β mutant, the Dutch variant

Levy, E., Prelli, F., & Frangione, B. (2006) · Journal of Alzheimer's Disease · doi:10.3233/jad-2006-9s337 · Cited by 24

β-amyloid and glutamate receptors

Gasparini, L., & Dityatev, A. E. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.03.005 · Cited by 24

Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice

Zhang, Y., Shao, H., Dong, Y., Swain, C. A., Yu, B., Xia, W., & Xie, Z. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-8 · Cited by 24

Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques

Hyman, B. T., Wenniger, J. J., & Tanzi, R. E. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90197-w · Cited by 24

Neuropathology in the Down's syndrome brain

Tanzi, R. E. (1996) · Nature Medicine · doi:10.1038/nm0196-31 · Cited by 24

Die Alzheimer-Krankheit

Jellinger, K. A. (1989) · Verhandlungen der Deutschen Gesellschaft für Neurologie · doi:10.1007/978-3-642-83771-5_5 · Cited by 24

Molecular biology of brain aging and neurodegenerative disorders

Wısnıewskı, T., & Frangione, B. (1996) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-1996-1132 · Cited by 24

Alzheimer's amyloid precursor protein-positive degenerative neurites exist even within kuru plaques not specific to Alzheimer's disease.

Ohgami, T., Kitamoto, T., Weidmann, A., Beyreuther, K. T., & Tateishi, J. (1991) · PubMed Central · Cited by 24

Alzheimer's Disease from the Perspective of the Systemic and Localized Forms of Amyloidosis

Castaño, E. M., & Frangione, B. (1991) · Brain Pathology · doi:10.1111/j.1750-3639.1991.tb00669.x · Cited by 24

Zinc Enhances Synthesis of Presenilin 1 in Mouse Primary Cortical Culture

Park, I.-H., Jung, M. W., Mori, H., & Mook‐Jung, I. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5243 · Cited by 23

Immunodetection of protein composition in cerebral amyloid extracts in Alzheimer's disease: Enrichment of retinol-binding protein

Maury, C. P. J., & Teppo, A. M. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90156-0 · Cited by 23

Mounting evidence for the involvement of zinc and copper in Alzheimer's disease

Moir, R. D., Atwood, Huang, Tanzi, & Bush, A. I. (1999) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.1999.00472.x · Cited by 23

Gene regulation during neuronal and non-neuronal differentiation of NTERA2 human teratocarcinoma-derived stem cells

Ackerman, S. L., Knowles, B. B., & Andrews, P. W. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90293-3 · Cited by 23

Tetrasomy 21 pter→q22.1 and Down syndrome: Molecular definition of the region

Daumer‐Haas, C., Schuffenhauer, S., Walther, J. U., Schipper, R. D., Porstmann, T., & Korenberg, J. R. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320530411 · Cited by 23

Alzheimer amyloid beta-protein precursor in sperm development.

Shoji, M., Kawarabayashi, T., Harigaya, Y., Yamaguchi, H., Hirai, S., Kamimura, T., & Sugiyama, T. (1990) · Europe PMC (PubMed Central) · Cited by 23

Alzheimer amyloid β/A4 peptide binding sites and a possible ‘APP-secretase’ activity associated with rat brain cortical membranes

Allsop, D., Tamamoto, T., Kametani, F., Miyazaki, N., & Ishii, T. (1991) · Brain Research · doi:10.1016/0006-8993(91)90905-b · Cited by 23

Mapping of the gene encoding the beta-amyloid precursor protein and its relationship to the Down syndrome region of chromosome 21.

Patterson, D., Gardiner, K., Kao, F., Tanzi, R. E., Watkins, P., & Gusella, J. F. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.21.8266 · Cited by 75

Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Jenkins, E. C., Devine-Gage, E. A., Robakis, N. K. R. K., Yao, X., Brown, W. T., Houck, G. E., Wolfe, G. C., Ramakrishna, N., Silverman, W. P., & Wı́sniewski, H. M. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90551-7 · Cited by 19

The mouse homolog of the human amyloid β protein (AD-AP) gene is located on the distal end of mouse chromosome 16: Further extension of the homology between human chromosome 21 and mouse chromosome 16

Lovett, M., Goldgaber, D., Ashley, P. L., Cox, D., Gajdusek, D. C., & Epstein, C. J. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80073-6 · Cited by 44

MINIREVIEW: Amyloid Protein in Alzheimer's Disease

Joachim, C. L., & Selkoe, D. J. (1989) · Journal of Gerontology · doi:10.1093/geronj/44.4.b77 · Cited by 21

β Amyloid Gene Duplication in Alzheimer's Disease and Karyotypically Normal Down Syndrome

Delabar, J. M., Goldgaber, D., Lamour, Y. A., Nicole, A., Huret, J. L., GROUCHY, J. D., Brown, P., Gajdusek, D. C., & Sinet, P. (1987) · Science · doi:10.1126/science.2950593 · Cited by 187