The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone
Abstract
Relief of intractable pain was produced in six human patients by stimulation of electrodes permanently implanted in the periventricular and periaqueductal gray matter. The level of stimulation sufficient to induce pain relief seems not to alter the acute pain threshold. Indiscriminate repetitive stimulation produced tolerance to both stimulation-produced pain relief and the analgesic action of narcotic medication; this process could be reversed by abstinence from stimulation. Stimulation-produced relief of pain was reversed by naloxone in five out of six patients. These results suggest that satisfactory alleviation of persistent pain in humans may be obtained by electronic stimulation.
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Citations
Cites
Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation
Reynolds, D. V. (1969) · Science · doi:10.1126/science.164.3878.444 · Cited by 1,389
Hughes, J. (1975) · Brain Research · doi:10.1016/0006-8993(75)90391-1 · Cited by 982
Analgesia from Electrical Stimulation in the Brainstem of the Rat
Mayer, D. J., Wolfle, T. L., Akil, H., Carder, B., & Liebeskind, J. C. (1971) · Science · doi:10.1126/science.174.4016.1351 · Cited by 772
Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis
Mayer, D. J., & Liebeskind, J. C. (1974) · Brain Research · doi:10.1016/0006-8993(74)90534-4 · Cited by 719
Central nervous system mechanisms of analgesia
Mayer, D. J., & Price, D. D. (1976) · Pain · doi:10.1016/0304-3959(76)90080-4 · Cited by 718
Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist
Akil, H., Mayer, D. J., & Liebeskind, J. C. (1976) · Science · doi:10.1126/science.1251210 · Cited by 669
Isolation and structure of an untriakontapeptide with opiate activity from camel pituitary glands.
Li, C. H., & Chung, D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.4.1145 · Cited by 637
Sensations Evoked by Stimulation in the Midbrain of Man
Nashold, B. S., Wilson, W. P., & Slaughter, D. G. (1969) · Journal of Neurosurgery · doi:10.3171/jns.1969.30.1.0014 · Cited by 549
Goldstein, A. (1976) · Science · doi:10.1126/science.959823 · Cited by 517
C fragment of lipotropin has a high affinity for brain opiate receptors
BRADBURY, A. F., SMYTH, D. G., SNELL, C. R., BIRDSALL, N. J. M., & HULME, E. C. (1976) · Nature · doi:10.1038/260793a0 · Cited by 489
Cited by
Endogenous pain control mechanisms: Review and hypothesis
Basbaum, A. I., & Fields, H. L. (1978) · Annals of Neurology · doi:10.1002/ana.410040511 · Cited by 1,241
Ossipov, M. H., Dussor, G. O., & Porreca, F. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43766 · Cited by 1,159
THE MECHANISM OF PLACEBO ANALGESIA
Levine, J., Gordon, N., & Fields, H. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92762-9 · Cited by 1,094
State-dependent opioid control of pain
Fields, H. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1431 · Cited by 946
Activation of the Opioidergic Descending Pain Control System Underlies Placebo Analgesia
Eippert, F., Bingel, U., Schoell, E. D., Yacubian, J., Klinger, R., Lorenz, J., & Büchel, C. (2009) · Neuron · doi:10.1016/j.neuron.2009.07.014 · Cited by 839
Metadata
- Authors
- Hosobuchi, Y., Adams, J. E., & Linchitz, R.
- Venue
- Science
- Published
- 1977-07-08
- Volume
- 197
- Issue
- 4299
- Pages
- 183-186
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2033470468
- Cited by
- 757
- References
- 31
- FWCI
- 69.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hosobuchi, Y., Adams, J. E., & Linchitz, R. (1977). Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone. Science. https://doi.org/10.1126/science.301658
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
