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Cited by 1,698

The DOI matches its Crossref record.

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

Koenig, Scott, Gendelman, Howard E., Orenstein, Jan M., Dal Canto, Mauro C., Pezeshkpour, Gholam H., Yungbluth, Margaret, Janotta, Frank, Aksamit, Allen, Martin, Malcolm A., Fauci, Anthony S.·1986·Science
DOI 10.1126/science.3016903
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Abstract

One of the common neurological complications in patients with the acquired immune deficiency syndrome (AIDS) is a subacute encephalopathy with progressive dementia. By using the techniques of cocultivation for virus isolation, in situ hybridization, immunocytochemistry, and transmission electron microscopy, the identity of an important cell type that supports replication of the AIDS retrovirus in brain tissue was determined in two affected individuals. These cells were mononucleated and multinucleated macrophages that actively synthesized viral RNA and produced progeny virions in the brains of the patients. Infected brain macrophages may serve as a reservoir for virus and as a vehicle for viral dissemination in the infected host.

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Metadata

Authors
Koenig, S., Gendelman, H. E., Orenstein, J. M., Dal Canto, M. C., Pezeshkpour, G. H., Yungbluth, M., Janotta, F., Aksamit, A., Martin, M. A., & Fauci, A. S.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1986-09-05
Volume
233
Issue
4768
Pages
1089-1093
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.3016903
OpenAlex
W2030692398
Cited by
1,698
References
0
FWCI
23.70
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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