Fresh Evidence Points to an Old Suspect: Calcium
Abstract
ALZHEIMER'S DISEASEProteins known to contribute to Alzheimer's pathology have been linked to disturbances in calcium ion regulation that could underlie neuronal death in the disease.
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The mechanism of oligomer synapto-toxicity appears to be tied closely to accumulation of excessive levels of Ca++, consistent with involvement of NMDA and mGluR5 receptors.
“The mechanism of oligomer synapto-toxicity appears to be tied closely to accumulation of excessive levels of Ca++ (Marx, 2007), consistent with involvement of NMDA and mGluR5 receptors.”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as Marx, 2007
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Additional file 2 of Hypertension, antihypertensive drugs, and age at onset of Huntington’s disease
Zhu, Y., Li, M., Bai, J., Wang, H., & Huang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23167729
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843879
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843876
Additional file 1 of Hypertension, antihypertensive drugs, and age at onset of Huntington’s disease
Zhu, Y., Li, M., Bai, J., Wang, H., & Huang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23167726
Additional file 3 of Hypertension, antihypertensive drugs, and age at onset of Huntington’s disease
Zhu, Y., Li, M., Bai, J., Wang, H., & Huang, X. (2023) · Figshare · doi:10.6084/m9.figshare.23167732
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843867
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843861
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843864
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843870
Ou, Y.-N., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843882
Ou, Y., Yang, Y.-X., Shen, X.-N., Ma, Y.-H., Chen, S.-D., Dong, Q., Tan, L., & Yu, J.-T. (2021) · Figshare · doi:10.6084/m9.figshare.13843885
Regulation of different kinases for Alzheimer's disease therapy: progresses and perspectives
Han, M., Liao, Q., He, S., Guo, L., Lu, Z., Wang, X., Sun, W., Duan, Y. B., Lyu, W., & Li, Q. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.110300
- Authors
- Marx, J.
- Corresponding author
- Marx, Jean
- Venue
- Science
- Published
- 2007-10-19
- Volume
- 318
- Issue
- 5849
- Pages
- 384-385
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1575733811
- Cited by
- 71
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 9 · 2022: 3 · 2021: 12 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 7
- Type
- other
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- Alzheimer's disease, calcium dysregulation, neuronal cell death, amyloid proteins, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Calcium, Cell Membrane, Cell Membrane Permeability, Cells, Cultured, Endoplasmic Reticulum, Humans, Membranes, Artificial, Mutation, Nerve Degeneration, Neurons, Calcium Channels, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Cell Death, Presenilins
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