The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo
Abstract
A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability-restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.
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“The positive results of HSC transplantation into cALD patients [24,356] indicated a role for brain microglia because microglia were thought to originate in bone marrow at that time [357].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [357]
In the citing paper
“Peripheral macrophages in the CNS of healthy mice showed an activated CD45hiMHC class IIhi phenotype, which was consistent with previous studies25.”
From MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway (2011) · cites this paper as [25]
Citations
Cites
Dijkstra, C. D., Döpp, E. A., Joling, P., & Kraal, G. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2463-8_50 · Cited by 1,598
Antigen-Presenting Function of the Macrophage
Unanue, E. R. (1984) · Annual Review of Immunology · doi:10.1146/annurev.iy.02.040184.002143 · Cited by 1,172
Ben‐Nun, A., Wekerle, H., & Cohen, I. R. (1981) · European Journal of Immunology · doi:10.1002/eji.1830110307 · Cited by 917
Immunologically Privileged Sites
Barker, C. F., & Billingham, R. E. (1978) · Advances in immunology · doi:10.1016/s0065-2776(08)60930-x · Cited by 815
Astrocytes present myelin basic protein to encephalitogenic T-cell lines
Fontana, A., Fierz, W., & Wekerle, H. (1984) · Nature · doi:10.1038/307273a0 · Cited by 771
Identification of Ia glycoproteins in rat thymus and purification from rat spleen
McMaster, W. R., & Williams, A. (1979) · European Journal of Immunology · doi:10.1002/eji.1830090603 · Cited by 678
Robinson, A. P., White, T. M., & Mason, D. W. (1986) · PubMed Central · Cited by 598
THE DETAILED DISTRIBUTION OF MHC CLASS II ANTIGENS IN NORMAL HUMAN ORGANS
Daar, A. S., Fuggle, S., Fabre, J. W., Ting, A., & Morris, P. J. (1984) · Transplantation · doi:10.1097/00007890-198409000-00019 · Cited by 432
Traugott, U., Scheinberg, L. C., & Raine, C. S. (1985) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(85)80043-6 · Cited by 241
Lampson, L. A., & Hickey, W. F. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.11.4054 · Cited by 230
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Research works printed but not linked: 6
- BARKER, C.F., ADVANCES IN IMMUNOLOGY 25: 1 (1971).
- COHEN, I.R., PROGRESS IN IMMUNOLOGY 5: 1129 (1984).
- DOLMAN, C.L., TXB NEUROPATHOLOGY: 117 (1985).
- GRIFFIN, D.E., NEUROIMMUNOLOGY: 193 (1984).
- HAGER, H, ACTA NEUROPATHOLOGICA 6: 279 (1975).
- Lampson, L. A., Proceedings of the National Academy of Sciences of the United States of America 81: 6476 (1984).
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Items 1,001–1,002 of 1,002
Metadata
- Authors
- Hickey, W. F., & Kimura, H.
- Affiliations
- University of Pennsylvania (US)
- ORCID
- Hickey, William F.
- Venue
- Science
- Published
- 1988-01-15
- Volume
- 239
- Issue
- 4837
- Pages
- 290-292
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076407459
- Cited by
- 1,466
- References
- 32
- Citations by year
- 2026: 6 · 2025: 16 · 2024: 21 · 2023: 13 · 2022: 26 · 2021: 15 · 2020: 19 · 2019: 30 · 2018: 26 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 32 · 2013: 34 · 2012: 48
- FWCI
- 37.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (KO7-NS0087)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- antigen presentation, bone marrow chimeras, bone marrow-derived cells, encephalitogenic T cells, multiple sclerosis, neuroimmunology, bone marrow transplantation
- MeSH terms
- Animals, Antigen-Presenting Cells, Astrocytes, Bone Marrow, Central Nervous System, Chimera, Encephalomyelitis, Autoimmune, Experimental, Endothelium, Graft vs Host Disease, Histocompatibility Antigens, Immunohistochemistry, Multiple Sclerosis, Neuroglia, Rats, Inbred Lew, T-Lymphocytes, Bone Marrow Transplantation, Rats
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