Cited by 1,466Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research StudiesT-cell and B-cell Immunology

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Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

Hickey, William F., Kimura, Hiromitsu·1988·Science

DOI 10.1126/science.3276004

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Abstract

A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability-restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.

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Authors: Hickey, W. F., & Kimura, H.
Affiliations: University of Pennsylvania (US)
ORCID: Hickey, William F.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1988-01-15
Volume: 239
Issue: 4837
Pages: 290-292
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.3276004
OpenAlex: W2076407459
Cited by: 1,466
References: 32
Citations by year: 2026: 6 · 2025: 16 · 2024: 21 · 2023: 13 · 2022: 26 · 2021: 15 · 2020: 19 · 2019: 30 · 2018: 26 · 2017: 33 · 2016: 30 · 2015: 34 · 2014: 32 · 2013: 34 · 2012: 48
FWCI: 37.37
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (KO7-NS0087)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: antigen presentation, bone marrow chimeras, bone marrow-derived cells, encephalitogenic T cells, multiple sclerosis, neuroimmunology, bone marrow transplantation
MeSH terms: Animals, Antigen-Presenting Cells, Astrocytes, Bone Marrow, Central Nervous System, Chimera, Encephalomyelitis, Autoimmune, Experimental, Endothelium, Graft vs Host Disease, Histocompatibility Antigens, Immunohistochemistry, Multiple Sclerosis, Neuroglia, Rats, Inbred Lew, T-Lymphocytes, Bone Marrow Transplantation, Rats

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Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

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