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Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome
Abstract
The androgen receptor (AR) mediates the actions of male sex steroids. Human AR genomic DNA was cloned from a flow-sorted human X chromosome library by using a consensus nucleotide sequence from the DNA-binding domain of the family of nuclear receptors. The AR gene was localized on the human X chromosome between the centromere and q13. Cloned complementary DNA, selected with an AR-specific oligonucleotide probe, was expressed in monkey kidney (COS) cells and yielded a high-affinity androgen-binding protein with steroid-binding specificity corresponding to that of native AR. A predominant messenger RNA species of 9.6 kilobases was identified in human, rat, and mouse tissues known to contain AR and was undetectable in tissues lacking AR androgen-binding activity, including kidney and liver from androgen-insensitive mice. The deduced amino acid sequence of AR within the DNA-binding domain has highest sequence identity with the progesterone receptor.
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Metadata
- Authors
- Lubahn, D. B., Joseph, D. R., Sullivan, P. M., Willard, H. F., French, F. S., & Wilson, E. M.
- Venue
- Science
- Published
- 1988-04-15
- Volume
- 240
- Issue
- 4850
- Pages
- 327-330
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050602600
- Cited by
- 1,016
- References
- 4
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- closed
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