The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on a Drosophila Cell Line
Abstract
The steroid molting hormone 20-hydroxyecdysone is the physiological inducer of molting and metamorphosis in insects. In ecdysone-sensitive Drosophila K c cells, the insecticide RH 5849 (1,2-dibenzoyl-1- tert -butylhydrazine) mimics the action of 20-hydroxyecdysone by causing the formation of processes, an inhibition of cell proliferation, and induction of acetylcholinesterase. RH 5849 also competes with [ 3 H]ponasterone A for high-affinity ecdysone receptor sites from K c cell extracts. Resistant cell populations selected by growth in the continued presence of either RH 5849 or 20-hydroxyecdysone are insensitive to both compounds and exhibit a decreased titer of measurable ecdysone receptors. Although it is less potent than 20-hydroxyecdysone in both whole-cell and cell-free receptor assays, RH 5849 is the first nonsteroidal ecdysone agonist.
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Cites
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
The morphological response of Kc-H cells to ecdysteroids: Hormonal specificity
Cherbas, L., Yonge, C. D., Cherbas, P., & Williams, C. M. (1980) · Wilhelm Roux's Archives of Developmental Biology · doi:10.1007/bf00848562 · Cited by 122
Cited by
New insecticides with ecdysteroidal and juvenile hormone activity
Dhadialla, T. S., Carlson, G. R., & Le, D. P. (1998) · Annual Review of Entomology · doi:10.1146/annurev.ento.43.1.545 · Cited by 912
Rusten, T. E., Lindmo, K., Juhász, G., Sass, M., Seglen, P. O., Brech, A., & Stenmark, H. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.07.005 · Cited by 490
Practical uses for ecdysteroids in mammals including humans: and update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1093/jis/3.1.7 · Cited by 196
Practical uses for ecdysteroids in mammals including humans: And update
Lafont, R., & Dinan, L. (2003) · Journal of Insect Science · doi:10.1673/031.003.0701 · Cited by 196
Clément, C. Y., Bradbrook, D. A., Lafont, R., & Dinan, L. (1993) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(93)90100-7 · Cited by 139
Metadata
- Authors
- Wing, K. D.
- Venue
- Science
- Published
- 1988-07-22
- Volume
- 241
- Issue
- 4864
- Pages
- 467-469
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148859347
- Cited by
- 359
- References
- 2
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wing, K. D. (1988). RH 5849, a Nonsteroidal Ecdysone Agonist: Effects on a Drosophila Cell Line. Science. https://doi.org/10.1126/science.3393913
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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