The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Abstract
Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated macrophages, has been implicated as an important mediator of the lethal effect of endotoxin. Recombinant human cachectin was infused into rats in an effort to determine whether cachectin, by itself, can elicit the derangements of host physiology caused by administration of endotoxin. When administered in quantities similar to those produced endogenously in response to endotoxin, cachectin causes hypotension, metabolic acidosis, hemoconcentration, and death within minutes to hours, as a result of respiratory arrest. Hyperglycemia and hyperkalemia were also observed after infusion. At necropsy, diffuse pulmonary inflammation and hemorrhage were apparent on gross and histopathologic examination, along with ischemic and hemorrhagic lesions of the gastrointestinal tract, and acute renal tubular necrosis. Thus, it appears that a single protein mediator (cachectin) is capable of inducing many of the deleterious effects of endotoxin.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consider as one example the case of TNF, a cytokine implicated as a necessary and sufficient mediator of lethal septic shock caused by infection with Gram-negative bacteria.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
In the citing paper
“Administration of TNF to healthy mammals (including humans) reproduces the hemodynamic, metabolic, immunological, and pathological manifestations of the disease (4)”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
In the citing paper
“Other pathophysiological activities ascribed to TNF were the capacity to cause fever and localized inflammation (4, 6).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. F., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512053132327 · Cited by 2,653
Beutler, B., Milsark, I. W., & Cerami, A. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,344
Self-citationCachectin and tumour necrosis factor as two sides of the same biological coin
Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,633
Self-citationTumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472
Self-citationModulation of endothelial cell hemostatic properties by tumor necrosis factor.
Nawroth, P. P., & Stern, D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.740 · Cited by 1,310
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132
Self-citationGamble, J. R., Harlan, J. M., Klebanoff, S. J., & Vadas, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8667 · Cited by 1,031
Dahlén, S., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. O. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
Shalaby, M. R., Aggarwal, B. B., Rinderknecht, E., Svedersky, L. P., Finkle, B. S., & Palladino, M. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.2069 · Cited by 916
Research works printed but not linked: 9
- BLISS, C.I., QUARTERLY JOURNAL OF PHARMACY AND PHARMACOLOGY 11: 192 (1938).
- Brake, A. J., Proceedings of the National Academy of Sciences of the United States of America 81: 4642 (1984).
- CORNELL, R.P., AM J PHYSL 227: 778 (1974).
- Dahlén, S. E., Proceedings of the National Academy of Sciences of the United States of America 78: 3887 (1981).
- FILKINS, J.P., PATHOPHYSIOLOGY RETI: 93 (1981).
- Kawakami, M., Proceedings of the National Academy of Sciences of the United States of America 79: 912 (1982).
- MENTEN, M.L., J M RES 44: 675 (1924).
- MORGAN, H.R., AM J PATHOL 19: 135 (1942).
- Sugarman, H. J., Current Problems in Surgery: 408 (1981).
Cited by
Sorted by citations
Items 401–500 of 1,005
Chorny, A., Anderson, P. O., González‐Rey, E., & Delgado, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8369 · Cited by 141
Cortistatin, a new antiinflammatory peptide with therapeutic effect on lethal endotoxemia
González‐Rey, E., Chorny, A., Robledo, G., & Delgado, M. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052017 · Cited by 142
Haptoglobin dampens endotoxin‐induced inflammatory effects both in vitro and in vivo
Arredouani, M. S., Kasran, A., Vanoirbeek, J. A., Berger, F. G., Baumann, H., & Ceuppens, J. L. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02071.x · Cited by 142
Plasma and BAL Cytokine Response to Corticosteroid Rescue Treatment in Late ARDS
Meduri, G. U., Headley, S., Tolley, E. A., Shelby, M., Stentz, F. B., & Postlethwaite, A. E. (1995) · CHEST Journal · doi:10.1378/chest.108.5.1315 · Cited by 140
Hughes, C. B., Grewal, H. P., Gaber, L. W., Kotb, M., El-Din, A. B. M., Mann, L., & Gaber, A. O. (1996) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)89568-2 · Cited by 141
Tumor necrosis factor in mediating experimental Haemophilus influenzae type B meningitis.
Mustafa, M. M., Ramilo, O., Olsen, K. D., Franklin, P., Hansen, E. J., Beutler, B., & McCracken, G. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114292 · Cited by 141
Self-citationSocial stress increases the susceptibility to endotoxic shock
Quan, N., Avitsur, R., Stark, J. L., He, L., Shah, M., Caligiuri, M., Padgett, D. A., Marucha, P. T., & Sheridan, J. F. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00273-9 · Cited by 177
Endothelial Cell Apoptosis in Lipopolysaccharide–Induced Lung Injury in Mice
Fujita, M., Kuwano, K., Kunitake, R., Hagimoto, N., Miyazaki, H., Kaneko, Y., Kawasaki, M., Maeyama, T., & Hara, N. (1998) · International Archives of Allergy and Immunology · doi:10.1159/000024011 · Cited by 139
Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin
Sewerynek, E., Melchiorri, D., Reiter, R. J., Ortíz, G. G., & Lewiñski, A. (1995) · European Journal of Pharmacology Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(95)90052-7 · Cited by 140
Is there a role for melatonin in the treatment of neoplastic cachexia?
Lissoni, P., Paolorossi, F., Tancini, G., Barni, S., Ardizzoia, A., Brivio, F., Zubelewicz‐Szkodzińska, B., & Chatikhine, V. A. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00136-0 · Cited by 140
Identification of a brainstem locus that inhibits tumor necrosis factor
Kressel, A. M., Tsaava, T., Levine, Y. A., Chang, E. H., Addorisio, M. E., Chang, Q., Burbach, B. J., Carnevale, D., Lembo, G., Zador, A. M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008213117 · Cited by 133
Self-citationGap junctions, homeostasis, and injury
Maio, A. D., Vega, V. L., & Contreras, J. E. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10108 · Cited by 141
The role of tumor necrosis factor in sepsis
Spooner, C. E., Markowitz, N. P., & Saravolatz, L. D. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90036-n · Cited by 138
Hölscher, C., Mohrs, M., Dai, W. J., Köhler, G., Ryffel, B., Schaub, G. A., Mossmann, H., & Brombacher, F. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.4075-4083.2000 · Cited by 139
Tuberculosis as a Primary Cause of Respiratory Failure Requiring Mechanical Ventilation
Penner, C., ROBERTS, D. E., Kunimoto, D. Y., Manfreda, J., & Long, R. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.867 · Cited by 138
FcγRIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis
Clatworthy, M. R., & Smith, K. G. C. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032197 · Cited by 139
Wolf, H., Fischer, M. B., Pühringer, H., Samstag, A., Vogel, E., & Eibl, M. M. (1994) · Blood · doi:10.1182/blood.v83.5.1278.1278 · Cited by 138
Granulocyte Depletion Prevents Tumor Necrosis Factor-mediated Acute Lung Injury in Guinea Pigs
Stephens, K. E., Ishizaka, A., Wu, Z., Larrick, J. W., & Raffin, T. A. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.5.1300 · Cited by 139
The Inflammatory Reflex and the Role of Complementary and Alternative Medical Therapies
Oke, S. L., & Tracey, K. J. (2009) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1393.013 · Cited by 139
Self-citationInflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models
Deng, X., Luyendyk, J. P., Ganey, P. E., & Roth, R. A. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001727 · Cited by 139
Sack, M. N. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00176-6 · Cited by 140
Karck, U., Peters, T., & Decker, K. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80008-4 · Cited by 136
Tumor necrosis factor mediates endotoxic effects in mice
Bauss, F., Dröge, W., & Männel, D. N. (1987) · Infection and Immunity · doi:10.1128/iai.55.7.1622-1625.1987 · Cited by 135
Tumour necrosis factor in infectious disease
Waters, J. P., Pober, J. S., & Bradley, J. R. (2013) · The Journal of Pathology · doi:10.1002/path.4187 · Cited by 136
The history, properties, and biological effects of cachectin
Beutler, B., & Cerami, A. (1988) · Biochemistry · doi:10.1021/bi00420a001 · Cited by 131
Self-citationVascular leak in sepsis: physiological basis and potential therapeutic advances
McMullan, R. R., McAuley, D. F., O’Kane, C. M., & Silversides, J. A. (2024) · Critical Care · doi:10.1186/s13054-024-04875-6 · Cited by 147
Tumor necrosis factor alpha-induced pulmonary vascular endothelial injury
Goldblum, S. E., Hennig, B., Jay, M., Yoneda, K., & McClain, C. J. (1989) · Infection and Immunity · doi:10.1128/iai.57.4.1218-1226.1989 · Cited by 133
Rusten, L., & Jacobsen, S. E. W. (1995) · Blood · doi:10.1182/blood.v85.4.989.bloodjournal854989 · Cited by 135
Formation of Free Radicals and Nitric Oxide Derivative of Hemoglobin in Rats During Shock Syndrome
Westenberger, U., Thanner, S., Ruf, H. H., GERSONDE, K., Sutter, G., & Trentz, O. (1990) · Free Radical Research Communications · doi:10.3109/10715769009109680 · Cited by 135
Prabhakar, U., Lipshutz, D. B., Bartus, J. O., Slivjak, M. J., Smith, E. F., Lee, J. C., & Esser, K. M. (1994) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(94)90054-x · Cited by 135
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
Vandevyver, S., Dejager, L., Bogaert, T. V., Kleyman, A., Liu, Y., Tuckermann, J. P., & Libert, C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60006 · Cited by 133
Means, T. K., Pavlovich, R., Roca, D. J., Vermeulen, M. W., & Fenton, M. J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.6.885 · Cited by 133
Kanemaki, T., Kitade, H., Kaibori, M., Sakitani, K., 平松, 義., Kamiyama, Y., Ito, S., & Okumura, T. (1998) · Hepatology · doi:10.1002/hep.510270515 · Cited by 133
Effect of endotoxin-induced monokines on glucose metabolism in the muscle cell line L6.
Lee, M. D., Zentella‐Dehesa, A., Vine, W., Pekala, P. H., & Cerami, A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2590 · Cited by 133
Self-citationSchlayer, H. ‐., Laaff, H., Peters, T., Woort-Menker, M., Estler, H.-C., Karck, U., Schaefer, H. E., & Decker, K. (1988) · Journal of Hepatology · doi:10.1016/s0168-8278(88)80488-4 · Cited by 132
Tumor Necrosis Factor Induces the Rapid Phosphorylation of the Mammalian Heat Shock Protein hsp28
Arrigo, A. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.3.1276 · Cited by 132
Bown, M. J., Nicholson, M. L., Bell, P. R. F., & Sayers, R. D. (2001) · European Journal of Vascular and Endovascular Surgery · doi:10.1053/ejvs.2001.1522 · Cited by 132
Serum concentration of tumor necrosis factor in patients with breast cancer
Sheen‐Chen, S., Chen, W., Eng, H., & Chou, F. (1997) · Breast Cancer Research and Treatment · doi:10.1023/a:1005736712307 · Cited by 132
Targeting HMGB1 for the treatment of sepsis and sepsis-induced organ injury
Deng, C., Zhao, L., Yang, Z. P., Shang, J., Wang, C., Shen, M., Jiang, S., Tian, L., Di, W., Chen, Y., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00676-7 · Cited by 139
Effects on leukocytes after injection of tumor necrosis factor into healthy humans
van der Poll, T., van Deventer, S. J. H., Hack, C. E., Wolbink, G., Aarden, L. A., Buller, H. R., & ten Cate, J. W. (1992) · Blood · doi:10.1182/blood.v79.3.693.693 · Cited by 128
Insulin Attenuates the Systemic Inflammatory Response to Thermal Trauma
Jeschke, M. G., Einspanier, R., Klein, D., & Jauch, K. (2002) · Molecular Medicine · doi:10.1007/bf03402024 · Cited by 130
The Regional Production of Cytokines and Lactate in Sepsis-Related Multiple Organ Failure
Douzinas, E. E., Tsidemiadou, P. D., Pitaridis, M. T., Andrianakis, I. A., Bobota-Chloraki, A., Katsouyanni, K., Sfyras, D., Malagari, K. S., & Roussos, C. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001289 · Cited by 130
Patton, J. S., Peters, P. M., McCabe, J., Crase, D., Hansen, S., Chen, A. B., & Liggitt, D. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113245 · Cited by 131
Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene
Blanchard, A. D., Page, K. R., Watkin, H., Hayward, P., Wong, T., Bartholomew, M. A., Quint, D. J., Daly, M. G., Garcia-Lopez, J., & CHAMPION, B. R. (2000) · European Journal of Immunology · doi:10.1002/1521-4141(200011)30:11 · Cited by 9
Friedland, J. S., Porter, J. C., Daryanani, S., Bland, J. M., Screaton, N. J., Vesely, M. J. J., Griffin, G. E., Bennett, E., & Remick, D. G. (1996) · Critical Care Medicine · doi:10.1097/00003246-199611000-00003 · Cited by 129
Interleukin 1, tumour necrosis factor‐alpha (cachectin) and the pathogenesis of cancer cachexia
Moldawer, L. L., Georgieff, M., & Lundholm, K. (1987) · Clinical Physiology · doi:10.1111/j.1475-097x.1987.tb00169.x · Cited by 127
Prostaglandins inhibit inflammatory mediator release from rat mast cells
Hogaboam, C. M., Bissonnette, É. Y., Chin, B. C., Befus, A. D., & Wallace, J. L. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90843-2 · Cited by 127
Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone.
Bianchi, M., Bloom, O., Raabe, T. D., Cohen, P. S., Chesney, J. A., Sherry, B. A., Schmidtmayerova, H., Calandra, T., Zhang, X., Bukrinsky, M., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.927 · Cited by 127
Self-citationIimuro, Y., Yamamoto, M. P., Kohno, H., Itakura, J., Fujii, H., & Matsumoto, Y. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.55.6.723 · Cited by 127
Goldberg, A. L., Kettelhut, Í. D. C., Furuno, K., Fagan, J. M., & Baracos, V. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113466 · Cited by 126
Immunohistochemical expression of tumor necrosis factor α in neonatal leukomalacia
Deguchi, K., Mizuguchi, M., & Takashima, S. (1996) · Pediatric Neurology · doi:10.1016/0887-8994(95)00223-5 · Cited by 125
Lipopolysaccharide Toxicity-Regulating Proteins in Bacteremia
Froon, A. H. M., Dentener, M. A., Greve, J.-W. M., Ramsay, G., & Buurman, W. A. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.5.1250 · Cited by 125
INFLAMMATORY RESPONSES AND MEDIATORS
Kim, P. K., & Deutschman, C. S. (2000) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70102-x · Cited by 126
Mohammad, M. K., Morran, M. P., Slotterbeck, B. D., Leaman, D. W., Sun, Y., von Grafenstein, H., Hong, S., & McInerney, M. F. (2006) · International Immunology · doi:10.1093/intimm/dxl045 · Cited by 126
Nagakawa, J., Hishinuma, I., Hirota, K., Miyamoto, K., Yamanaka, T., Tsukidate, K., Katayama, K., & Yamatsu, I. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90965-4 · Cited by 122
Yamamoto, S., Tanabe, M., Wakabayashi, G., Shimazu, M., Matsumoto, K., & Kitajima, M. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6106 · Cited by 123
Tumour necrosis factor-? and the failing heart
von Haehling, S., Jankowska, E. A., & Anker, S. D. (2004) · Basic Research in Cardiology · doi:10.1007/s00395-003-0433-8 · Cited by 121
Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function
Tang, D., Kang, R., Xiao, W., Zhang, H., Lotze, M. T., Wang, H., & Xiao, X. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0119oc · Cited by 124
Organ Interactions in the Adult Respiratory Distress Syndrome during Sepsis
Matuschak, G. M., & Rinaldo, J. E. (1988) · CHEST Journal · doi:10.1378/chest.94.2.400 · Cited by 123
Krown, K. A., Yasui, K., Brooker, M. J., Dubin, A. E., Nguyen, C., Harris, G. L., McDonough, P. M., Glembotski, C. C., Palade, P., & Sabbadini, R. A. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01238-5 · Cited by 123
Tumor Necrosis Factor Inhibits Human Myogenesis In Vitro
Miller, S. C., Ito, H., Blau, H. M., & Torti, F. M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.6.2295-2301.1988 · Cited by 125
Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.
Wispé, J. R., Clark, J. C., Warner, B. B., Fajardo, D., Hull, W. E., Holtzman, R. B., & Whitsett, J. A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114929 · Cited by 123
Endotoxin Tolerance Is Associated With Reduced Secretion of Tumor Necrosis Factor
Sánchez-Cantú, L. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410120082016 · Cited by 123
Opal, S. M., Cross, A. S., Kelly, N. M., SADOFF, J. C., Bodmer, M., Palardy, J., & Victor, G. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/161.6.1148 · Cited by 123
Novel Therapies for Sepsis: A Review
Deans, K. J., Haley, M., Natanson, C., Eichacker, P. Q., & Minneci, P. C. (2005) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000158244.69179.94 · Cited by 122
Zhao, Y. X., He, W., Jing, X. H., Liu, J. L., Rong, P. J., Ben, H., Liu, K., & Zhu, B. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/627023 · Cited by 122
Líénard, D., Lejeune, F. J., & Ewalenko, P. (1992) · World Journal of Surgery · doi:10.1007/bf02071526 · Cited by 122
TNF in the Inflammatory Response
M�nnel, D., & Echtenacher, B. (1999) · KARGER eBooks · doi:10.1159/000058757 · Cited by 121
Tumor necrosis factor alpha has a protective role in a murine model of systemic candidiasis
Louie, A., Baltch, A. L., Smith, R. P., Franke, M. A., Ritz, W. J., Singh, J. K., & Gordon, M. A. (1994) · Infection and Immunity · doi:10.1128/iai.62.7.2761-2772.1994 · Cited by 120
Regulation by C5a of Neutrophil Activation during Sepsis
Riedemann, N. C., Guo, R., Bernacki, K. D., Reuben, J. S., Laudes, I. J., Neff, T. A., Gao, H., Speyer, C. L., Sarma, V. J., Zetoune, F. S., et al. (2003) · Immunity · doi:10.1016/s1074-7613(03)00206-1 · Cited by 121
Ertel, W., Keel, M. J. B., Bonaccio, M., Steckholzer, U., Gallati, H., Kenney, J. S., & Trentz, O. (1995) · doi:10.1097/00005373-199511000-00011 · Cited by 121
Acute Kidney Injury in Patients with Sepsis and Septic Shock: Risk Factors and Clinical Outcomes
Suh, S. H., Kim, C. S., Choi, J. S., Bae, E. H., Kwon, S., & Kim, S. W. (2013) · Yonsei Medical Journal · doi:10.3349/ymj.2013.54.4.965 · Cited by 118
The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation
Rae, L., Fidler, P. E., & Gibran, N. S. (2016) · Critical Care Clinics · doi:10.1016/j.ccc.2016.06.001 · Cited by 120
Tumor Necrosis Factor and Lymphotoxin
Beyaert, R., & Fiers, W. (1998) · Elsevier eBooks · doi:10.1016/b978-012498340-3/50025-7 · Cited by 119
Metabolic Responses to Cachectin/TNF
Tracey, K. J., & Cerami, A. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb00173.x · Cited by 120
Self-citationThe diverse roles of the TNF axis in cancer progression and metastasis.
Ham, B., Fernández, M. C., D'Costa, Z., & Brodt, P. (2016) · PubMed · Cited by 120
Pentoxifylline Prevents Tumor Necrosis Factor-induced Lung Injury
Lilly, C. M., SANDHU, J. S., Ishizaka, A., Harada, H., Yonemaru, M., Larrick, J. W., Shi, T.-X., O'Hanley, P. D., & Raffin, T. A. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.6.1361 · Cited by 119
Metabolism of Sepsis and Multiple Organ Failure
MICHIE, H. R. (1996) · World Journal of Surgery · doi:10.1007/s002689900072 · Cited by 118
Decoster, E., Vanhaesebroeck, B., Vandenabeele, P., Grooten, J., & Fiers, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18473 · Cited by 118
The cell in shock: the origin of multiple organ failure
Schlag, G., Redl, H. R., & Hallström, S. (1991) · Resuscitation · doi:10.1016/0300-9572(91)90044-y · Cited by 118
Bianchi, M., Ulrich, P. C., Bloom, O., Meistrell, M. E., Zimmerman, G. A., Schmidtmayerova, H., Bukrinsky, M., Donnelley, T., Bucala, R., Sherry, B. A., et al. (1995) · Molecular Medicine · doi:10.1007/bf03401550 · Cited by 116
Self-citationDisseminated Intravascular Coagulation
Bick, R. L., Arun, B. K., & Frenkel, E. P. (1999) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000022493 · Cited by 119
Human Immunodeficiency Virus Infection
Villamor, E., Manji, K. P., & Fawzi, W. W. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-464-3_11 · Cited by 116
Nawabi, M., Block, K. P., Chakrabarti, M. C., & Buse, M. G. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114421 · Cited by 117
Tumor Necrosis Factor Alpha Inhibits Hepatocyte Mitochondrial Respiration
Stadler, J., Bentz, B. G., Harbrecht, B. G., Silvio, M. D., CURRAN, R. D., Billiar, T. R., HOFFMAN, R. A., & Simmons, R. L. (1992) · Annals of Surgery · doi:10.1097/00000658-199211000-00003 · Cited by 115
Vagal control of digestion: Modulation by central neural and peripheral endocrine factors
Rogers, R. C., McTigue, D. M., & Hermann, G. E. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00040-l · Cited by 117
Isobe, H., Okajima, K., Uchiba, M., Mizutani, A., Harada, N., Nagasaki, A., & Okabe, K. (2001) · Circulation · doi:10.1161/hc3501.093799 · Cited by 117
Acute Alcohol Infusion Suppresses Endotoxin‐induced Serum Tumor Necrosis Factor
D'Souza, N. B., Bagby, G. J., Nelson, S., Lang, C. H., & Spitzer, J. J. (1989) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1989.tb00329.x · Cited by 117
Sakao, Y., Takeda, K., Tsutsui, H., Kaisho, T., Nomura, F., Okamura, H., Nakanishi, K., & Akira, S. (1999) · International Immunology · doi:10.1093/intimm/11.3.471 · Cited by 117
Levy, G. A., Liu, M., Ding, J., Yuwaraj, S., Leibowitz, J. L., Marsden, P. A., Ning, Q., Kovalinka, A., & Phillips, M. J. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64992-9 · Cited by 116
Tumor Necrosis Factor (Cachectin) in Human Visceral Leishmaniasis
Barral‐Netto, M., Badaró, R. J. D. S., Barral, A. M. P., de Almeida, R. P., Santos, S., Badaró, F., Pedral-Sampaio, D., Carvalho, E. M., Falcoff, E., & FALCOFF, R. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/163.4.853 · Cited by 116
Kwon, O., Molitoris, B. A., Pescovitz, M. D., & Kelly, K. J. (2003) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(03)00206-3 · Cited by 116
Teti, G., Mancuso, G., & Tomasello, F. F. (1993) · Infection and Immunity · doi:10.1128/iai.61.1.227-235.1993 · Cited by 116
de Bont, E., Martens, A., van Raan, J., Samson, G., Fetter, W., Okken, A., de Leij, L., & Kimpen, J. L. L. (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13121.x · Cited by 116
van der Poll, T., Jansen, J., van Leenen, D., von der Mohlen, M., Levi, M. M., Cate, H. T., Gallati, H., ten Cate, J. W., & van Deventer, S. J. H. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.4.955 · Cited by 116
Phull, A. R., & Kim, S. J. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.09.051 · Cited by 115
Involvement and dual effects of nitric oxide in septic shock
Wołkow, P. P. (1998) · Inflammation Research · doi:10.1007/s000110050309 · Cited by 115
Tumour necrosis factor‐alpha (TNF‐α): The good, the bad and potentially very effective
BARBARA, J. A., Ostade, X. V., & Lopez, A. F. (1996) · Immunology and Cell Biology · doi:10.1038/icb.1996.73 · Cited by 113
Aderka, D., Sorkine, P., Abu-Abid, S., Lev, D. C., Setton, A., Cope, A. P., Wallach, D., & Klausner, J. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci694 · Cited by 115
Taffet, S. M., Singhel, K. J., Overholtzer, J. F., & Shurtleff, S. A. (1989) · Cellular Immunology · doi:10.1016/0008-8749(89)90198-6 · Cited by 114
Metadata
- Authors
- Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., Shires, G. T., & Cerami, A.
- Affiliations
- Weill Cornell Medical Center (US)
- Department of Surgery, New York Hospital-Cornell Medical Center, New York, NY 10021.
- Venue
- Science
- Published
- 1986-10-24
- Volume
- 234
- Issue
- 4775
- Pages
- 470-474
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968713831
- Cited by
- 2,549
- References
- 45
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 16 · 2023: 12 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 21 · 2017: 21 · 2016: 28 · 2015: 19 · 2014: 30 · 2013: 38 · 2012: 29
- FWCI
- 107.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- TNF-α, endotoxin, septic shock, tissue damage, hypotension, metabolic acidosis, hemoconcentration, respiratory arrest, hyperglycemia, hyperkalemia, pulmonary hemorrhage, acute tubular necrosis, gastrointestinal bleeding, macrophages
- MeSH terms
- Animals, Blood Glucose, Endotoxins, Female, Glycoproteins, Humans, Potassium, Recombinant Proteins, Shock, Sodium, Tumor Necrosis Factor-alpha, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review