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Shock and Tissue Injury Induced by Recombinant Human Cachectin
Abstract
Cachectin (tumor necrosis factor), a protein produced in large quantities by endotoxin-activated macrophages, has been implicated as an important mediator of the lethal effect of endotoxin. Recombinant human cachectin was infused into rats in an effort to determine whether cachectin, by itself, can elicit the derangements of host physiology caused by administration of endotoxin. When administered in quantities similar to those produced endogenously in response to endotoxin, cachectin causes hypotension, metabolic acidosis, hemoconcentration, and death within minutes to hours, as a result of respiratory arrest. Hyperglycemia and hyperkalemia were also observed after infusion. At necropsy, diffuse pulmonary inflammation and hemorrhage were apparent on gross and histopathologic examination, along with ischemic and hemorrhagic lesions of the gastrointestinal tract, and acute renal tubular necrosis. Thus, it appears that a single protein mediator (cachectin) is capable of inducing many of the deleterious effects of endotoxin.
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“Consider as one example the case of TNF, a cytokine implicated as a necessary and sufficient mediator of lethal septic shock caused by infection with Gram-negative bacteria.”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
In the citing paper
“Administration of TNF to healthy mammals (including humans) reproduces the hemodynamic, metabolic, immunological, and pathological manifestations of the disease (4)”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
In the citing paper
“Other pathophysiological activities ascribed to TNF were the capacity to cause fever and localized inflammation (4, 6).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [4]
Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. F., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512053132327 · Cited by 2,653
Beutler, B., Milsark, I. W., & Cerami, A. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,344
Self-citationCachectin and tumour necrosis factor as two sides of the same biological coin
Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,633
Self-citationTumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472
Self-citationModulation of endothelial cell hemostatic properties by tumor necrosis factor.
Nawroth, P. P., & Stern, D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.740 · Cited by 1,310
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132
Self-citationGamble, J. R., Harlan, J. M., Klebanoff, S. J., & Vadas, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8667 · Cited by 1,031
Dahlén, S., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. O. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019
Shalaby, M. R., Aggarwal, B. B., Rinderknecht, E., Svedersky, L. P., Finkle, B. S., & Palladino, M. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.2069 · Cited by 916
Research works printed but not linked: 9
- BLISS, C.I., QUARTERLY JOURNAL OF PHARMACY AND PHARMACOLOGY 11: 192 (1938).
- Brake, A. J., Proceedings of the National Academy of Sciences of the United States of America 81: 4642 (1984).
- CORNELL, R.P., AM J PHYSL 227: 778 (1974).
- Dahlén, S. E., Proceedings of the National Academy of Sciences of the United States of America 78: 3887 (1981).
- FILKINS, J.P., PATHOPHYSIOLOGY RETI: 93 (1981).
- Kawakami, M., Proceedings of the National Academy of Sciences of the United States of America 79: 912 (1982).
- MENTEN, M.L., J M RES 44: 675 (1924).
- MORGAN, H.R., AM J PATHOL 19: 135 (1942).
- Sugarman, H. J., Current Problems in Surgery: 408 (1981).
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Items 801–900 of 1,005
SUITTERS, A. J., Foulkes, R., Opal, S. M., Palardy, J., Emtage, J. S., Rolfe, M., Stephens, S., Morgan, A. A., Holt, A. R., & Chaplin, L. C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.3.849 · Cited by 67
Post-translational control of NLRP3 inflammasome signaling
O'Keefe, M. E., Dubyak, G., & Abbott, D. W. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107386 · Cited by 68
Roy, M. (2004) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2003.12.005 · Cited by 74
Martelli, D., Farmer, D., McKinley, M. J., Yao, S. T., & McAllen, R. M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00298.2018 · Cited by 67
Harðardóttir, I., & Kinsella, J. (1992) · Journal of Nutrition · doi:10.1093/jn/122.10.1942 · Cited by 66
Thrall, R. S., Vogel, S., Evans, R., & Shultz, L. D. (1997) · Europe PMC (PubMed Central) · Cited by 66
Grohmann, U., Snick, J. V., Campanile, F., Silla, S., Giampietri, A., Vacca, C., Renauld, J., Fioretti, M. C., & Puccetti, P. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4197 · Cited by 66
Spielmann, S., Kerner, T., Ahlers, O., Keh, D., Gerlach, M., & Gerlach, H. (2001) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2001.045003364.x · Cited by 65
ten Hagen, T. L. M., Seynhaeve, A. L. B., van Tiel, S. T., Ruiter, D. J., & Eggermont, A. M. M. (2001) · International Journal of Cancer · doi:10.1002/ijc.1578 · Cited by 65
Lainez, B. (2003) · International Immunology · doi:10.1093/intimm/dxh014 · Cited by 65
Superantigens: The Good, the Bad, and the Ugly
Torres, B. A., Kominsky, S. L., Perrin, G. Q., Hobeika, A. C., & Johnson, H. M. (2001) · Experimental Biology and Medicine · doi:10.1177/153537020122600303 · Cited by 65
Dietary glycine blunts lung inflammatory cell influx following acute endotoxin
Wheeler, M. D., Rose, M., Yamashima, S., Enomoto, N., Seabra, V., Madren, J., & Thurman, R. G. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.279.2.l390 · Cited by 65
Ando, T., & Dunn, A. J. (1999) · NeuroImmunoModulation · doi:10.1159/000026391 · Cited by 65
Barton, P. A., & Warren, J. S. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1474-1481.1993 · Cited by 65
Couriel, D. R., Hicks, K. L., Giralt, S. A., & Champlin, R. E. (2000) · Current Opinion in Oncology · doi:10.1097/00001622-200011000-00011 · Cited by 65
Beutler, B., & Poltorak, A. (2001) · PubMed · Cited by 64
Self-citationRollins, D. A., Coppo, M., & Rogatsky, I. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1005 · Cited by 66
Marik, P. E., & Varón, J. (2001) · Disease-a-Month · doi:10.1067/mda.2001.119745 · Cited by 62
Role of garlic in the prevention of ischemia‐reperfusion injury
Şener, G., Şakarcan, A., & Yeğen, B. Ç. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700078 · Cited by 64
Extensive bone marrow necrosis in patients with cancer and tumor necrosis factor activity in plasma
Knupp, C., Pekala, P. H., & Cornelius, P. K. (1988) · American Journal of Hematology · doi:10.1002/ajh.2830290408 · Cited by 64
Endotoxin-induced Acute Lung Injury in Rats. Role of Insulin
Boichot, E., Sannomiya, P., Escofier, N., Germain, N., Fortes, Z. B., & Lagente, V. (1999) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.1999.0212 · Cited by 62
Terregino, C. A., Lopez, B. L., Karras, D. J., Killian, A. J., & Arnold, G. K. (2000) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(00)70101-6 · Cited by 64
Cellular activation mechanisms in septic shock
Han, J. (1998) · Frontiers in bioscience · doi:10.2741/a293 · Cited by 64
Opal, S. M., Cross, A. S., SADOFF, J. C., Collins, H. H., Kelly, N. M., Victor, G., Palardy, J., & Bodmer, M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115390 · Cited by 64
Τakayama, T. K. (1990) · Archives of Surgery · doi:10.1001/archsurg.1990.01410130031004 · Cited by 64
Cachectin: Its Impact On Metabolism And Nutritional Status
Moldawer, L. L., Lowry, S. F., & Cerami, A. (1988) · Annual Review of Nutrition · doi:10.1146/annurev.nu.08.070188.003101 · Cited by 64
Self-citationOxidant stress and essential fatty acids in patients with risk and established ARDS
Kutala, V. K., Rao, S. M., Gayani, R., Mohan, I. K., & Naidu, M. U. R. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00264-3 · Cited by 63
INNATE IMMUNITY, CYTOKINES, AND PULMONARY HOST DEFENSE
Nelson, S., & Summer, W. R. (1998) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(05)70198-7 · Cited by 64
Peptidoglycan of Staphylococcus aureus causes inflammation and organ injury in the rat*
Wang, J. E., Dahle, M. K., Yndestad, A., Bauer, I., McDonald, M. C., Aukrust, P., Foster, S. J., Bauer, M. W., Aasen, A. O., & Thiemermann, C. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000109775.22138.8f · Cited by 63
Keogh, C. V. (1990) · Archives of Surgery · doi:10.1001/archsurg.1990.01410130085011 · Cited by 63
Elevated levels of TNF in the joints of adjuvant arthritic rats
Smith-Oliver, T. A., Noel, L. S., Stimpson, S., Yarnall, D. P., & Connolly, K. M. (1993) · Cytokine · doi:10.1016/1043-4666(93)90060-i · Cited by 63
Ertel, W., Morrison, M. H., Ayala, A., Perrin, M. M., & Chaudry, I. H. (1991) · Annals of Surgery · doi:10.1097/00000658-199103000-00015 · Cited by 63
Amelioration of doxorubicin-induced cardiac and renal toxicity by pirfenidone in rats
Du, X., Schelegle, E. S., Mohr, F. C., Margolin, S. B., Giri, S. N., & Al-Bayati, M. A. (2004) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-003-0703-z · Cited by 62
Fat meets the cholinergic antiinflammatory pathway
Tracey, K. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051760 · Cited by 63
Self-citationKarkar, A. M., Koshino, Y., Cashman, S. J., Dash, A., Bonnefoy, J., Meager, A., & Rees, A. J. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb07948.x · Cited by 62
Wollenberg, G. K., DeForge, L. E., Bolgos, G. L., & Remick, D. G. (1993) · PubMed Central · Cited by 62
Are the Catabolic Effects of Tumor Necrosis Factor Mediated by Glucocorticoids?
Mealy, K. (1990) · Archives of Surgery · doi:10.1001/archsurg.1990.01410130044006 · Cited by 62
Nakano, K., Suzuki, S., & Oh, C. (1987) · Brain Behavior and Immunity · doi:10.1016/0889-1591(87)90018-3 · Cited by 62
Nuclear receptors in inflammation control: Repression by GR and beyond
Chinenov, Y. V., Gupte, R., & Rogatsky, I. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.04.006 · Cited by 61
Hohenberger, P., & Wysocki, W. M. (2008) · The Oncologist · doi:10.1634/theoncologist.2007-0165 · Cited by 62
Lefèvre, N., Corazza, F., Duchateau, J., Désir, J., & Casimir, G. J. (2012) · Shock · doi:10.1097/shk.0b013e3182571e46 · Cited by 63
Kobayashi, T. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf048 · Cited by 61
Zentella‐Dehesa, A., Manogue, K. R., & Cerami, A. (1993) · Cytokine · doi:10.1016/1043-4666(93)90033-2 · Cited by 61
Self-citationStraaten, H. M. O., Jansen, P. G. M., Velthuis, H. T., Beenakkers, I. C. M., Stoutenbeek, C. P., van Deventer, S. J. H., Sturk, A., Eysman, L., & Wildevuur, C. R. H. (1996) · Intensive Care Medicine · doi:10.1007/bf01700449 · Cited by 61
Yang, S., Zhou, M., Chaudry, I. H., & Wang, P. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.4.g1014 · Cited by 61
Tumor necrosis factor-α and the failing human heart-TNFα and heart failure
Oral, H., Kapadia, S., Nakano, M., Torre‐Amione, G., Lee, J. K. T., Lee-Jackson, D., Young, J. B., & Mann, D. L. (1995) · Clinical Cardiology · doi:10.1002/clc.4960181605 · Cited by 61
Tumor Necrosis Factor Induces Adult Respiratory Distress Syndrome in Rats
Ferrari‐Baliviera, E. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410120046010 · Cited by 61
Reversal of the toxic effects of cachectin by concurrent insulin administration
Fraker, D. L., Merino, M. J., & Norton, J. A. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.6.e725 · Cited by 61
Current Understanding of the Pathogenesis of Gram-negative Shock
Waage, A., Brandtzeeg, P., Espevik, T., & Halstensen, A. I. (1991) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(20)30755-8 · Cited by 61
Disseminated Intravascular Coagulation
Bick, R. L. (1992) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30274-0 · Cited by 59
Fukushima, R., Gianotti, L. V., ALEXANDER, J. W., & Pyles, T. (1992) · Annals of Surgery · doi:10.1097/00000658-199210000-00007 · Cited by 61
A role for ELAM-1 in the pathogenesis of MOF during septic shock
Engelberts, I., Samyo, S. K., Leeuwenberg, J. F. M., van der Linden, J., & Buurman, W. A. (1992) · Journal of Surgical Research · doi:10.1016/0022-4804(92)90025-u · Cited by 61
Tennenberg, S. D., & Solomkin, J. S. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.47.3.217 · Cited by 61
Neural reflex regulation of systemic inflammation: potential new targets for sepsis therapy
Fernández, R., Nardocci, G., Navarro, C., Reyes, E. P., Acuña‐Castillo, C., & Cortes, P. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00489 · Cited by 60
The Effect of Aging on Circulating Levels of Proinflammatory Cytokines During Septic Shock
Marik, P. E., Zaloga, G. P., & and the Norasept II Study Investigators (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.49003.x · Cited by 58
Estriol sensitizes rat Kupffer cells via gut-derived endotoxin
Enomoto, N., Yamashina, S., Schemmer, P., Rivera, C. A., Bradford, B. U., Enomoto, A., Brenner, D. A., & Thurman, R. G. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.3.g671 · Cited by 60
A low level of TNF-α mediates hemorrhage-induced acute lung injury via p55 TNF receptor
Song, Y., Ao, L., Raeburn, C. D., Calkins, C. M., Abraham, E. H., Harken, A. H., & Meng, X. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.3.l677 · Cited by 60
Swantek, J. L., Christerson, L. B., & Cobb, M. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11667 · Cited by 60
Rusten, L. S., Smeland, E. B., Jacobsen, F. W., Lien, E., Lesslauer, W., Loetscher, H., Dubois, C. M., & Jacobsen, S. E. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117303 · Cited by 60
Mechanisms and implications of hypoalbuminemia in head-injured patients
McClain, C. J., Hennig, B., Ott, L. G., Goldblum, S. E., & Young, A. B. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.69.3.0386 · Cited by 60
Dorinsky, P., & Gadek, J. E. (1990) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(21)00757-7 · Cited by 60
Han, J., Beutler, B., & Huez, G. A. (1991) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(91)90032-h · Cited by 60
Self-citationTransforming growth factor-β in the regulation of the immune response
Sasaki, H., Pollard, R. B., Schmitt, D. A., & Suzuki, F. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90241-f · Cited by 60
Cholinergic modulation of inflammation.
Pavlov, V. A. (2008) · PubMed Central · Cited by 59
Woźniacka, A. J., Lesiak, A., Boncela, J., Smolarczyk, K., McCauliffe, D. P., & Sysa‐Jędrzejowska, A. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08804.x · Cited by 59
HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis
Andersson, U., & Tracey, K. J. (2004) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2004.04.007 · Cited by 59
Self-citationPathways of renal injury in systemic gram‐negative sepsis
El‐Achkar, T. M., Hosein, M., & Dagher, P. C. (2008) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2008.02007.x · Cited by 59
Kittigul, L., Temprom, W., Sujirarat, D., & Kittigul, C. (2000) · Journal of Virological Methods · doi:10.1016/s0166-0934(00)00215-9 · Cited by 59
Gosain, A., & Gamelli, R. L. (2005) · Journal of Burn Care & Rehabilitation · doi:10.1097/01.bcr.0000150214.72984.44 · Cited by 59
Streptococcal cysteine protease augments lung injury induced by products of group A streptococci
Shanley, T. P., Schrier, D. J., Kapur, V., Kehoe, M., Musser, J. M., & Ward, P. A. (1996) · Infection and Immunity · doi:10.1128/iai.64.3.870-877.1996 · Cited by 59
Zuckerman, S. H., & Bendele, A. M. (1989) · Infection and Immunity · doi:10.1128/iai.57.10.3009-3013.1989 · Cited by 59
Acute effects of tumor necrosis factor on the microcirculation in rat cremaster muscle.
Vicaut, É., Hou, X., Payen, D. M., Bousseau, A., & Tedgui, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115165 · Cited by 59
Monoclonal antibodies to human tumor necrosis factor α: In vitro and in vivo application
Möller, A., Emling, F., Blohm, D. H., Schlick, E., & Schollmeier, K. (1990) · Cytokine · doi:10.1016/1043-4666(90)90011-h · Cited by 59
Heinzelmann, M., & Bosshart, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2280 · Cited by 58
Role of Tumor Necrosis Factor in Sepsis and Acute Lung injury
Simpson, S. Q., & Casey, L. C. (1989) · Critical Care Clinics · doi:10.1016/s0749-0704(18)30449-4 · Cited by 58
Tsukagoshi, H., Shimizu, Y., Kawata, T., Hisada, T., Shimizu, Y., Iwamae, S., Ishizuka, T., Iizuka, K., Dobashi, K., & Mori, M. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00218-x · Cited by 58
Tumor necrosis factor-α as a myocardial depressant substance
Odeh, M. (1993) · International Journal of Cardiology · doi:10.1016/0167-5273(93)90053-j · Cited by 58
Cauwels, A., Molle, W. V., Janssen, B. J., Everaerdt, B., Huang, P. L., Fiers, W., & Brouckaert, P. (2000) · Immunity · doi:10.1016/s1074-7613(00)00022-4 · Cited by 56
Tumor Necrosis Factor in Septicemic Melioidosis
Suputtamongkol, Y., Kwiatkowski, D. P., Dance, D. A. B., Chaowagul, W., & White, N. J. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/165.3.561 · Cited by 58
Neural Control of Inflammation
Steinberg, B. E., Sundman, E., Terrando, N., Eriksson, L. I., & Olofsson, P. S. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001083 · Cited by 59
Kume, H., OKAZAKI, K., & SASAKI, H. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.1281 · Cited by 57
Zhang, R., Hadlock, K. G., Do, H., Yu, S. W. Y., Honrada, R., Champion, S., Forshew, D. A., Madison, C. A., Katz, J., Miller, R. G., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.08.012 · Cited by 57
Experimental Human Endotoxemia: A Model of the Systemic Inflammatory Response Syndrome?
Calvano, S. E., & Coyle, S. M. (2012) · Surgical Infections · doi:10.1089/sur.2012.155 · Cited by 57
Sepsis Induced by Cecal Ligation and Puncture
Wen, H. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-481-4_15 · Cited by 57
Targeting high mobility group box 1 as a late-acting mediator of inflammation
Czura, C. J., & Tracey, K. J. (2003) · Critical Care Medicine · doi:10.1097/00003246-200301001-00007 · Cited by 57
Self-citationKirkpatrick, C. J., Bittinger, F., Klein, C. L., Hauptmann, S., & Klosterhalfen, B. (1996) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00199506 · Cited by 57
Endothelial monocyte-activating polypeptide-II and its functions in (patho)physiological processes
van Horssen, R., Eggermont, A. M. M., & ten Hagen, T. L. M. (2006) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2006.08.001 · Cited by 57
IVIG Adverse Reactions: Potential Role of Cytokines and Vasoactive Substances
Багдасарян, А. А., Tonetta, S. A., Harel, W., Mamidi, R. N. V. S., & Uemura, Y. (1998) · Vox Sanguinis · doi:10.1046/j.1423-0410.1998.7420074.x · Cited by 57
Rennick, D. M., Berg, D., & Holland, G. (1992) · Progress in Growth Factor Research · doi:10.1016/0955-2235(92)90020-i · Cited by 57
Kwak, D. J., Augustine, N. H., Borges, W. G., Joyner, J. L., Green, W. F., & Hill, H. R. (2000) · Infection and Immunity · doi:10.1128/iai.68.1.320-327.2000 · Cited by 57
Buescher, E. S. (1994) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30344-0 · Cited by 57
Stern, E. L., Quan, N., Proescholdt, M. G., & Herkenham, M. A. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00318-0 · Cited by 57
Eggimann, P., Chioléro, R. L., Chassot, P., Líénard, D., Gérain, J., & Lejeune, F. J. (1995) · CHEST Journal · doi:10.1378/chest.107.4.1074 · Cited by 57
Adams, J. L., & Czuprynski, C. J. (1990) · Journal of Leukocyte Biology · doi:10.1002/jlb.48.6.549 · Cited by 57
Loffreda, S., Rai, R., Yang, S. Q., Lin, H., & Diehl, A. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9178702 · Cited by 57
Removal of Endotoxin and Cytokines by Adsorbents and the Effect of Plasma Protein Binding
Nagaki, M., Hughes, R. D., Lau, J. Y. N., & Williams, R. L. (1991) · The International Journal of Artificial Organs · doi:10.1177/039139889101400109 · Cited by 57
The Physiologic Basis for Anticytokine Clinical Trials in the Treatment of Sepsis 1
Cain, B. S., Meldrum, D. R., Harken, A. H., & McIntyre, R. C. (1998) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(98)00036-2 · Cited by 57
Kallinowski, F., Schaefer, C. A., Tyler, G., & Vaupel, P. W. (1989) · British Journal of Cancer · doi:10.1038/bjc.1989.312 · Cited by 57
Renal Toll-like receptors: recent advances and implications for disease
El‐Achkar, T. M., & Dagher, P. C. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0300 · Cited by 56
Inactivated Marburg virus elicits a nonprotective immune response in Rhesus monkeys
Ignatyev, G. M., Agafonov, A. P., Strel'tsova, M. A., & Kashentseva, E. A. (1996) · Journal of Biotechnology · doi:10.1016/0168-1656(95)00104-2 · Cited by 56
Metadata
- Authors
- Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., Shires, G. T., & Cerami, A.
- Affiliations
- Weill Cornell Medical Center (US)
- Department of Surgery, New York Hospital-Cornell Medical Center, New York, NY 10021.
- Venue
- Science
- Published
- 1986-10-24
- Volume
- 234
- Issue
- 4775
- Pages
- 470-474
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1968713831
- Cited by
- 2,549
- References
- 45
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 16 · 2023: 12 · 2022: 13 · 2021: 18 · 2020: 19 · 2019: 18 · 2018: 21 · 2017: 21 · 2016: 28 · 2015: 19 · 2014: 30 · 2013: 38 · 2012: 29
- FWCI
- 107.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- TNF-α, endotoxin, septic shock, tissue damage, hypotension, metabolic acidosis, hemoconcentration, respiratory arrest, hyperglycemia, hyperkalemia, pulmonary hemorrhage, acute tubular necrosis, gastrointestinal bleeding, macrophages
- MeSH terms
- Animals, Blood Glucose, Endotoxins, Female, Glycoproteins, Humans, Potassium, Recombinant Proteins, Shock, Sodium, Tumor Necrosis Factor-alpha, Rats
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