Shock and Tissue Injury Induced by Recombinant Human Cachectin

An endotoxin-induced serum factor that causes necrosis of tumors

Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532

Observations on the Systemic Administration of Autologous Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 to Patients with Metastatic Cancer

Rosenberg, S. A., Lotze, M. T., Muul, L. M., Leitman, S. F., Chang, A. E., Ettinghausen, S. E., Matory, Y. L., Skibber, J. M., Shiloni, E., Vetto, J. T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198512053132327 · Cited by 2,653

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

Beutler, B., Milsark, I. W., & Cerami, A. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,344

Cachectin and tumour necrosis factor as two sides of the same biological coin

Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,633

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

Nawroth, P. P., & Stern, D. (1986) · The Journal of Experimental Medicine · doi:10.1084/jem.163.3.740 · Cited by 1,310

Identity of tumour necrosis factor and the macrophage-secreted factor cachectin

Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132

Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

Gamble, J. R., Harlan, J. M., Klebanoff, S. J., & Vadas, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.24.8667 · Cited by 1,031

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.

Dahlén, S., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. A., & Samuelsson, B. O. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3887 · Cited by 1,019

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

Shalaby, M. R., Aggarwal, B. B., Rinderknecht, E., Svedersky, L. P., Finkle, B. S., & Palladino, M. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.3.2069 · Cited by 916

A tumor necrosis factor binding protein is present in human biological fluids

Peetre, C., Thysell, H., GRUBB, A. O., & Olsson, I. (1988) · European Journal Of Haematology · doi:10.1111/j.1600-0609.1988.tb00220.x · Cited by 115

Disseminated intravascular coagulation due to malignancy.

Colman, R. W., & Rubin, R. N. (1990) · PubMed · Cited by 114

The proinflammatory cytokine response to coagulation and endotoxin in whole blood

Johnson, K., Aarden, L. A., Choi, Y., de Groot, E. R., & Creasey, A. A. (1996) · Blood · doi:10.1182/blood.v87.12.5051.bloodjournal87125051 · Cited by 114

Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages

Ding, X., Kambara, H., Guo, R., Kanneganti, A., Acosta-Zaldívar, M., Li, J., Liu, F., Bei, T., Qi, W., Xie, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-27034-9 · Cited by 115

Characteristic neuropathology of leukomalacia in extremely low birth weight infants

Deguchi, K., Oguchi, K., & Takashima, S. (1997) · Pediatric Neurology · doi:10.1016/s0887-8994(97)00041-6 · Cited by 113

TNF and TNFR polymorphisms in severe sepsis and septic shock: a prospective multicentre study

Gordon, A. C., Lagan, A. L., Aganna, E., Cheung, L., Peters, C. J., McDermott, M., Millo, J. L., Welsh, K. I., Holloway, P. A. H., Hitman, G. A., et al. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364136 · Cited by 113

The role of gut‐derived bacterial toxins and free radicals in alcohol‐induced liver injury

Thurman, R. G., Bradford, B. U., Iimuro, Y., Knecht, K. T., Arteel, G. E., Yin, M., Connor, H. D., Wall, C. A., Raleigh, J. A., von Frankenberg, M., et al. (1998) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.1998.13.s1.39 · Cited by 113

Analysis of Tlr4-Mediated LPS Signal Transduction in Macrophages by Mutational Modification of the Receptor

Du, X., Poltorak, A. N., Silva, M., & Beutler, B. (1999) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1999.0262 · Cited by 113

Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.

Windsor, A. C. J., Walsh, C. J., Mullen, P. G., Cook, D. J., Fisher, B. J., Blocher, C., Leeper-Woodford, S. K., Sugerman, H. J., & Fowler, A. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116351 · Cited by 114

Recombinant Human Tumor Necrosis Factor Produces Hemodynamic Changes Characteristic of Sepsis and Endotoxemia

Schirmer, W. J. (1989) · Archives of Surgery · doi:10.1001/archsurg.1989.01410040055012 · Cited by 113

Models of the pathogenesis of necrotizing enterocolitis

Kliegman, R. M. (1990) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)81123-0 · Cited by 112

Molecular mechanisms in down-regulation of tumor necrosis factor expression.

Haas, J. G., Baeuerle, P. A., Riethmüller, G., & Ziegler-Heitbrock, H. W. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9563 · Cited by 111

Immunologic Role of the Cholinergic Anti‐Inflammatory Pathway and the Nicotinic Acetylcholine α7 Receptor

Gallowitsch‐Puerta, M., & Tracey, K. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1358.024 · Cited by 111

Use of Predicted Risk of Mortality to evaluate the efficacy of anticytokine therapy in sepsis

Knaus, W. A., Harrell, F. E., LaBrecque, J. F., Wagner, D. P., Pribble, J. P., Draper, E. A., Fisher, C. J., & Soll, L. (1996) · Critical Care Medicine · doi:10.1097/00003246-199601000-00010 · Cited by 111

Superantigen and endotoxin synergize in the induction of lethal shock

Blank, C. A., Luz, A., Bendigs, S., Erdmann, A. A., Wagner, H., & Heeg, K. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270405 · Cited by 111

Regulation of the Expression of the Inducible Isoform of Nitric Oxide Synthase

Szabó, C., & Thiemermann, C. (1995) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61083-2 · Cited by 111

Ion channels in inflammation

Eisenhut, M., & Wallace, H. L. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0917-y · Cited by 111

Enhanced production of bovine tumor necrosis factor-α during the periparturient period

Sordillo, L. M., Pighetti, G. M., & Davis, M. R. (1995) · Veterinary Immunology and Immunopathology · doi:10.1016/0165-2427(95)05465-0 · Cited by 110

Co‐expression of TNFα and IL‐1β in human acute pulmonary fibrotic diseases: An immunohistochemical analysis

Pan, L., Ohtani, H., Yamauchi, K., & Nagura, H. (1996) · Pathology International · doi:10.1111/j.1440-1827.1996.tb03584.x · Cited by 110

The protective effect of melatonin on renal ischemia–reperfusion injury in the rat

Şener, G., Şehirli, A. Ö., Keyer‐Uysal, M., Arbak, S., Ersoy, Y., & Yeğen, B. Ç. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.1848.x · Cited by 110

Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis

Yang, M., Cao, L., Xie, M., Yu, Y., Kang, R., Yang, L., Zhao, M., & Tang, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.05.013 · Cited by 110

Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1 alpha/beta expression and suppression.

Ulich, T. R., Guo, K., Irwin, B., Remick, D. G., & Davatelis, G. (1990) · PubMed Central · Cited by 110

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

Kettelhut, Í. D. C., & Goldberg, A. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113467 · Cited by 110

Production of Tumor Necrosis Factor by Human Monocytes in Response to Toxic-Shock-Syndrome Toxin-1

Parsonnet, J., & Gillis, Z. A. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.5.1026 · Cited by 109

Fulminant hepatic failure in murine hepatitis virus strain 3 infection: tissue-specific expression of a novel fgl2 prothrombinase

Ding, J., Ning, Q., Liu, M. F., Lai, A. C.-K., Leibowitz, J. L., Peltekian, K. M., Cole, E., Fung, L. S., Holloway, C., Marsden, P. A., et al. (1997) · Journal of Virology · doi:10.1128/jvi.71.12.9223-9230.1997 · Cited by 108

HMGB1 in Sepsis

Andersson, U., & Tracey, K. J. (2003) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540310016286 · Cited by 108

Understanding the role of inflammatory cytokines in malaria and related diseases

Clark, I. A., Alleva, L. M., Budd, A. C., & Cowden, W. B. (2007) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2007.07.002 · Cited by 110

Induction of tumour necrosis factor-? by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

Philpott, M., Baguley, B. C., & Ching, L. (1995) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00689199 · Cited by 108

Polymorphonuclear Neutrophils: An Effective Antimicrobial Force

Sawyer, D. W., Donowitz, G. R., & Mandell, G. L. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.supplement_7.s1532 · Cited by 108

Tumor necrosis factor and interleukin-6 in Candida albicans infection in normal and granulocytopenic mice

Steinshamn, S., & Waage, A. (1992) · Infection and Immunity · doi:10.1128/iai.60.10.4003-4008.1992 · Cited by 108

Pathophysiologic mechanisms in septic shock

King, E. G., Bauzá, G., Mella, J. R., & Remick, D. G. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.110 · Cited by 114

Cardiac dysfunction in sepsis: new theories and clinical implications

Grocott-Mason, R. M., & Shah, A. M. (1998) · Intensive Care Medicine · doi:10.1007/s001340050570 · Cited by 103

Effectiveness of a Human Monoclonal Anti-Endotoxin Antibody (HA-1A) in Gram-Negative Sepsis: Relationship to Endotoxin and Cytokine Levels

Wortel, C. H., Möhlen, M. A. M. V. D., van Deventer, S. J. H., Sprung, C. L., Jastremski, M., Lubbers, M. J., Smith, C. R., Allen, I. E., & ten Cate, J. W. (1992) · The Journal of Infectious Diseases · doi:10.1093/infdis/166.6.1367 · Cited by 107

Roles of the Neutrophil and Other Mediators in Adult Respiratory Distress Syndrome

Swank, D. W., & Moore, S. B. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)64981-7 · Cited by 106

Anti-TNF Therapy, from Rationale to Standard of Care: What Lessons Has It Taught Us?

Feldmann, M., & Maini, R. N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1090051 · Cited by 106

Interleukin-1 Blockade Attenuates Mediator Release and Dysregulation of the Hemostatic Mechanism During Human Sepsis

Boermeester, M. A. (1995) · Archives of Surgery · doi:10.1001/archsurg.1995.01430070061012 · Cited by 106

Synthetic Surfactant (Exosurf) Inhibits Endotoxin-stimulated Cytokine Secretion by Human Alveolar Macrophages

Thomassen, M. J., Meeker, D. P., Antal, J. M., Connors, M. J., & Wiedemann, H. P. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.3.257 · Cited by 106

Role of granulocytes in increased host resistance to Candida albicans induced by recombinant interleukin-1

Kullberg, B. J., van 't Wout, J. W., & van Furth, R. (1990) · Infection and Immunity · doi:10.1128/iai.58.10.3319-3324.1990 · Cited by 105

Tumour necrosis factor: a cytokine with multiple biological activities

Semenzato, G. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.78 · Cited by 105

Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats

Taniguchi, T., Yamamoto, K., Ohmoto, N., Ohta, K., & Kobayashi, T. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00032 · Cited by 104

A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.

Harel, Y., Silva, M., Giroir, B. P., Weinberg, A. G., Cleary, T., & Beutler, B. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116811 · Cited by 105

Second cancers and other late side effects of cancer treatment.A review

Boivin, J.-F. (1990) · Cancer · doi:10.1002/1097-0142(19900201)65:3+ · Cited by 58

Stress activated cytokines and the heart

Mann, D. L. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00043-3 · Cited by 104

Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B

Nagaki, M., Muto, Y., Ohnishi, H., Yasuda, S., Sano, K., Naito, T., Maeda, T., Yamada, T., & Moriwaki, H. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90604-1 · Cited by 104

Cellular localization of tumor necrosis factor (TNF)-alpha transcripts in normal bowel and in necrotizing enterocolitis. TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages.

Tan, X., Hsueh, W., & González-Crussí, F. (1993) · PubMed Central · Cited by 104

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

Tredget, E. E., Yu, Y., Zhong, S., Burini, R. C., Okusawa, S., Gelfand, J. A., Dinarello, C. A., Young, V. R., & Burke, J. F. (1988) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1988.255.6.e760 · Cited by 104

Tumor necrosis factor-alpha-mediated decrease in glutathione increases the sensitivity of pulmonary vascular endothelial cells to H2O2.

Ishii, Y., Partridge, C. A., Vecchio, P. J. D., & Malik, A. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115658 · Cited by 104

Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog

Preiser, J., Schmartz, D., der Linden, P. V., Content, J., Bussche, P. V., Buurman, W. A., Sebald, W., Dupont, É., Pinsky, M. R., & Vincent, J. (1991) · Cytokine · doi:10.1016/1043-4666(91)90002-u · Cited by 104

p38 Mitogen-Activated Protein Kinase

Kerkelä, R., & Force, T. L. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.005 · Cited by 104

Cachectin/tumor necrosis factor: An endogenous mediator of shock and inflammation

Beutler, B., & Cerami, A. (1986) · Immunologic Research · doi:10.1007/bf02935501 · Cited by 102

Cytokine measurements and interpretation of cytokine assays in human disease

Whiteside, T. L. (1994) · Journal of Clinical Immunology · doi:10.1007/bf01546317 · Cited by 103

Effect of recombinant human tumor necrosis factor-alpha on cerebral oxygen uptake, cerebrospinal fluid lactate, and cerebral blood flow in the rabbit: role of nitric oxide.

Tureen, J. H. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117755 · Cited by 103

Modulation of endogenous hormone action by recombinant human tumor necrosis factor.

Warren, R. S., Donner, D. B., Starnes, H. F., & Brennan, M. F. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8619 · Cited by 102

Inflammatory Cytokines and Lipopolysaccharide Induce Fas-Mediated Apoptosis in Renal Tubular Cells

Jo, S., Cha, D. R., Cho, W. Y., Kim, H. K., Chang, K. H., Yun, S. Y., & Won, N. H. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000064280 · Cited by 102

Molecules and mechanisms operating in septic shock: lessons from knockout mice

Gutierrez‐Ramos, J. C., & Bluethmann, H. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01085-2 · Cited by 102

Differential effects of hemorrhage on kupffer cells: decreased antigen presentation despite increased inflammatory cytokine (IL-1, IL-6 and TNF) release

Ayala, A. (1992) · Cytokine · doi:10.1016/1043-4666(92)90039-t · Cited by 102

Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.

Rogy, M. A., Auffenberg, T., Espat, N. J., Philip, R., Remick, D. G., Wollenberg, G. K., Copeland, E. M., & Moldawer, L. L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.6.2289 · Cited by 102

Genetic polymorphisms in sepsis

Dahmer, M. K., Randolph, A., Vitali, S., & Quasney, M. W. (2005) · Pediatric Critical Care Medicine · doi:10.1097/01.pcc.0000161970.44470.c7 · Cited by 101

Tumor Necrosis Factor-α Regulates Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Expression in Vascular Smooth Muscle

Anwar, A., Zahid, A., Scheidegger, K. J., Brink, M., & Delafontaine, P. (2002) · Circulation · doi:10.1161/hc1002.105187 · Cited by 101

Cytokines in Patients with Polytrauma

DeLong, W. G., & Born, C. T. (2004) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000130840.64528.1e · Cited by 101

Admission cortisol and adrenocorticotrophic hormone levels in children with meningococcal disease: Evidence of adrenal insufficiency?

Riordan, F. A. I., Thomson, A. P. J., Ratcliffe, J. M., Sills, J., Diver, M. J., & Hart, C. A. (1999) · Critical Care Medicine · doi:10.1097/00003246-199910000-00032 · Cited by 101

Tumor Necrosis Factor-α Mediates Acid Aspiration-induced Systemic Organ Injury

Goldman, G., Welbourn, R., Kobzik, L., VALERI, C. R., Sheṕro, D., & Hechtman, H. B. (1990) · Annals of Surgery · doi:10.1097/00000658-199010000-00013 · Cited by 101

Tumor necrosis factor expression in human epithelial tumor cell lines.

Spriggs, D. R., Imamura, K., Rodriguez, C., Sariban, E., & Kufe, D. W. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113341 · Cited by 101

Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis

Englert, J. A., & Rogers, A. J. (2016) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2016.01.011 · Cited by 102

Bacterial Peptidoglycan-associated Lipoprotein Is Released into the Bloodstream in Gram-negative Sepsis and Causes Inflammation and Death in Mice

Hellman, J., Roberts, J. D., Tehan, M. M., Allaire, J. E., & Warren, H. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109696200 · Cited by 100

TNF-α neutralization ameliorates obstruction-induced renal fibrosis and dysfunction

Meldrum, K. K., Misseri, R., Metcalfe, P., Dinarello, C. A., Hile, K. L., & Meldrum, D. R. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00620.2005 · Cited by 97

Macrophage migration inhibitory factor: Cytokine, hormone, or enzyme?

Swope, M. D., & Lolis, E. (2005) · Springer eBooks · doi:10.1007/bfb0033647 · Cited by 100

Immunologic Therapy for ARDS, Septic Shock, and Multiple-Organ Failure

John, R. C. S., & Dorinsky, P. (1993) · CHEST Journal · doi:10.1378/chest.103.3.932 · Cited by 100

Role of TNF in Mediating Renal Insufficiency Following Cardiac Surgery: Evidence of a Postbypass Cardiorenal Syndrome

Meldrum, D. R., & DONNAHOO, K. K. (1999) · Journal of Surgical Research · doi:10.1006/jsre.1999.5660 · Cited by 99

Resistance of Collagenase-2 (Matrix Metalloproteinase-8)-Deficient Mice to TNF-Induced Lethal Hepatitis

Lint, P. V., Wielockx, B., Puimège, L., Noël, A., López-Otı́n, C., & Libert, C. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7642 · Cited by 98

Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway

Czura, C. J., Friedman, S. G., & Tracey, K. J. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103225002755 · Cited by 97

Differential Regulation of Tumor Necrosis Factor-Alpha in Human Alveolar Macrophages and Peripheral Blood Monocytes: A Cellular and Molecular Analysis

Strieter, R. M., Remick, D. G., Lynch, J. P., Genord, M. A., Raiford, C. L., Spengler, R. N., & Kunkel, S. L. (1989) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/1.1.57 · Cited by 98

Reciprocal modulation of interleukin-1 beta (IL-1 beta) and IL-1 receptors by lipopolysaccharide (endotoxin) treatment in the mouse brain-endocrine-immune axis

Takao, T., Culp, S. G., & Souza, E. B. D. (1993) · Endocrinology · doi:10.1210/endo.132.4.8462448 · Cited by 98

Tumor necrosis factor

Wakefield, P. E., James, W. D., Samlaska, C. P., & Meltzer, M. S. (1991) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(91)70102-8 · Cited by 100

Induction by Toxic-Shock-Syndrome Toxin-1 of a Circulating Tumor Necrosis Factor-Like Substance in Rabbits and of Immunoreactive Tumor Necrosis Factor and Interleukin-1 from Human Mononuclear Cells

Ikejima, T., Okusawa, S., van der Meer, J. W. M., & Dinarello, C. A. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.5.1017 · Cited by 98

The pathophysiology of advanced heart failure

Baig, M. K., Mahon, N., McKenna, W. J., Caforio, A. L. P., Bonow, R. O., Francis, G. S., & Gheorghiade, M. (1998) · American Heart Journal · doi:10.1016/s0002-8703(98)70252-2 · Cited by 97

Carcinoembryonic Antigen Family Receptor Specificity of Neisseria meningitidis Opa Variants Influences Adherence to and Invasion of Proinflammatory Cytokine-Activated Endothelial Cells

Muenzner, P., Dehio, C., Fujiwara, T., Achtman, M., Meyer, T. F., & Gray‐Owen, S. D. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3601-3607.2000 · Cited by 97

Antibody and cytokine responses in a mouse pulmonary model of Shigella flexneri serotype 2a infection

Verg, L. L. V. D., Mallett, C. P., Collins, H. H., Larsen, T., Hammack, C., & Hale, T. L. (1995) · Infection and Immunity · doi:10.1128/iai.63.5.1947-1954.1995 · Cited by 97

Plasma cytokine levels in patients with severe burn injury-with reference to the relationship between infection and prognosis

YAMADA, Y., Endo, S., & Inada, K. (1996) · Burns · doi:10.1016/s0305-4179(96)00052-6 · Cited by 97

Effect of cyclo‐oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide‐induced neutrophil infiltration in mouse lung

de Moraes, V. L. G., Vargaftig, B. B., Lefort, J., Meager, A., & Chignard, M. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15356.x · Cited by 97

Dietary manipulation of the inflammatory response

Grimble, R. F. (1992) · Proceedings of The Nutrition Society · doi:10.1079/pns19920039 · Cited by 97

Mechanisms of tumor necrosis factor action.

Schütze, S., Machleidt, T., & Krönke, M. (1992) · PubMed · Cited by 96

Plasma tumor necrosis factor soluble receptors in chronic renal failure

Brockhaus, M., Bar‐Khayim, Y., Gurwicz, S., Frensdorff, A., & Haran, N. (1992) · Kidney International · doi:10.1038/ki.1992.332 · Cited by 97

A nervous connection

Libert, C. (2003) · Nature · doi:10.1038/421328a · Cited by 96

TNF-Related Ligands and Their Receptors

Orlinick, J. R., & Chao, M. V. (1998) · Cellular Signalling · doi:10.1016/s0898-6568(98)00018-7 · Cited by 94

The role of the complement system in shock and tissue injury induced by tumour necrosis factor and endotoxin.

Hsueh, W., Sun, X., Rioja, L. N., & González-Crussí, F. (1990) · PubMed Central · Cited by 96

Attenuation of Acute Lung Injury in Septic Guinea Pigs by Pentoxifylline

Ishizaka, A., Wu, Z., Stephens, K. E., Harada, H., Hogue, R. S., O'Hanley, P. D., & Raffin, T. A. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.2.376 · Cited by 96

Tumor necrosis factor (TNF)‐alpha activates c‐raf‐1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.

Belka, C., Wiegmann, K., Adam, D., Holland, R., Neuloh, M., Herrmann, F., Krönke, M., & Brach, M. A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07099.x · Cited by 95

Infection of Neonatal Mice with Sindbis Virus Results in a Systemic Inflammatory Response Syndrome

Klimstra, W. B., Ryman, K. D., Bernard, K. A., Nguyen, K. B., Biron, C. A., & Johnston, R. E. (1999) · Journal of Virology · doi:10.1128/jvi.73.12.10387-10398.1999 · Cited by 95

TNF-α-dependent bilateral renal injury is induced by unilateral renal ischemia-reperfusion

Meldrum, K. K., Meldrum, D. R., Meng, X., Ao, L., & Harken, A. H. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00072.2001 · Cited by 95

Constitutive synthesis of tumor necrosis factor in the thymus.

Giroir, B. P., Brown, T., & Beutler, B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.11.4864 · Cited by 95

Tumor necrosis factor increases in vivo glucose utilization of macrophage-rich tissues

Mészáros, K., Lang, C. H., Bagby, G. J., & Spitzer, J. J. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91596-8 · Cited by 95

Tumour Necrosis Factor Alpha (TNF‐α) and Interleukin 6 in a Zymosan‐Induced Shock Model

von Asmuth, E. J., Maessen, J. G., van der Linden, J., & Buurman, W. A. (1990) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.1990.tb02925.x · Cited by 95

The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death

Qiu, P., Cui, X., Barochia, A. V., Li, Y., Natanson, C., & Eichacker, P. Q. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.623125 · Cited by 94

Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats.

Duansak, D., Somboonwong, J., & Patumraj, S. (2003) · PubMed · Cited by 94

Characterization of Exosurf (Surfactant)-Mediated Suppression of Stimulated Human Alveolar Macrophage Cytokine Responses

Thomassen, M. J., Antal, J. M., Connors, M. J., Meeker, D. P., & Wiedemann, H. P. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.10.4.8136155 · Cited by 94

Tumor Necrosis Factor Alpha Receptor I Is Important for Survival fromStreptococcus pneumoniaeInfections

O’Brien, D. P., Briles, D. E., Szalai, A. J., Tu, A.-H. T., Sanz, I., & Nahm, M. H. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.595-601.1999 · Cited by 94

Cytokine elevations in infants with bacterial and aseptic meningitis

Dulkerian, S. J., Kilpatrick, L. E., Costarino, A. T., McCawley, L. J., Fein, J. A., Corcoran, L., Zirin, S., & Harris, M. C. (1995) · The Journal of Pediatrics · doi:10.1016/s0022-3476(95)70199-0 · Cited by 94

Mediators in the Pathogenesis of Toxic Shock Syndrome: Overview

Parsonnet, J. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.supplement_1.s263 · Cited by 94

Necrotizing Enterocolitis: A Review of Pathogenetic Mechanisms and Implications for Prevention

Caplan, M. S., & MacKendrick, W. (1993) · Pediatric Pathology · doi:10.3109/15513819309048223 · Cited by 94

Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.

Tracey, K. J., Lowry, S. F., Fahey, T. J., Albert, J. D., Fong, Y., HESSE, D. G., Beutler, B., Manogue, K. R., Calvano, S. E., & Hu, W. M. (1987) · PubMed · Cited by 429

Cachectin/TNF: A Macrophage Protein That Induces Cachexia and Shock

Fong, Y., Lowry, S. F., & Cerami, A. (1988) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860718801200608 · Cited by 19

Brief Definitive Report EFFECT OF y INTERFERON ON CACHECTIN EXPRESSION BY MONONUCLEAR PHAGOCYTES Reversal of the lpsd (Endotoxin Resistance) Phenotype

Beutler, B., Tkacenko, V., Milsark, I. W., Krochin, N., & Cerami, A. (2013)

Cachectin: A Macrophage Protein that Induces a Catabolic State in Infected Animals

Cerami, A. (1987) · Springer eBooks · doi:10.1007/978-3-642-83118-8_30 · Cited by 1

The Common Mediator of Shock, Cachexia, and Tumor Necrosis

Beutler, B., & Cerami, A. (1988) · Advances in immunology · doi:10.1016/s0065-2776(08)60846-9 · Cited by 169