Hippocampo-Hypothalamic Connections: Origin in Subicular Cortex, Not Ammon's Horn
Abstract
An autoradiographic study of the subcortical projections of the rat hippocampal formation shows that the efferent fibers of the hippocampus proper (fields CA1-4 of Ammon's horn) do not project to the hypothalamus but are confined to the precommissural fornix, ending primarily in the septum. The fibers that are distributed by way of the fornix system to the hypothalamus (principally the arcuate-ventromedial region and the mammillary nuclei) and the anterior thalamus arise from the subicular region of the cerebral cortex (that is, the subiculum, presubiculum, and parasubiculum).
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The nucleus accumbens receives innervation from multiple brain regions including the prefrontal cortex and hippocampus.
“It is well documented that the nucleus accumbens receives innervation from multiple brain regions including the prefrontal cortex and hippocampus [85, 86].”
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Self-citationConnections of the rat lateral septal complex 1Published on the World Wide Web on 2 June 1997. 1
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Self-citationAn autoradiographic study of the efferent connections of the preoptic region in the rat
Swanson, L. W. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901670207 · Cited by 588 · see citing works
Self-citationAfferent connections to the bed nucleus of the stria terminalis
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Haddon, J. E., Titherage, D., Heckenast, J. R., Carter, J., Owen, M. J., Hall, J., Wilkinson, L. S., & Jones, M. W. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02969-x · Cited by 6 · see citing works
“It is well documented that the nucleus accumbens receives innervation from multiple brain regions including the prefrontal cortex and hippocampus [85, 86].”
Background
- Authors
- Swanson, L. W., & Cowan, W. M.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Swanson, L. W.
- Venue
- Science
- Published
- 1975-07-25
- Volume
- 189
- Issue
- 4199
- Pages
- 303-304
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980009209
- Cited by
- 305
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 10
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Keywords
- hippocampal formation, subiculum, presubiculum, parasubiculum, Ammon's horn, fornix, septum, arcuate nucleus, mammillary bodies, anterior thalamic nuclei, subcortical projections, rats
- MeSH terms
- Animals, Autoradiography, Axonal Transport, Brain Mapping, Hippocampus, Hypothalamus, Injections, Neural Pathways, Proline, Septal Nuclei, Thalamic Nuclei, Tritium, Rats
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