The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Transcriptional Enhancer Elements in the Mouse Immunoglobulin Heavy Chain Locus
Abstract
Two regions in the immunoglobulin heavy chain locus were tested for their ability to enhance transcription of the SV40 early promoter. A portion of the intervening sequence between the heavy chain joining region (J h ) and the constant region of the μ chain (Cμ) can enhance transcription when it is cloned either 5′ or 3′ to the SV40 early promoter. The region between Cα and the alpha switch site, which occurs 5′ to the translocated c-myc oncogene in many murine plasmacytomas, does not show transcriptional enhancer activity in this assay.
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“Genetic models have demonstrated that alteration of enhancer function can cause hematologic diseases49, 50.”
From Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia (2015) · cites this paper as [49]
Citations
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Metadata
- Authors
- Mercola, M., Wang, X.-F., Olsen, J., & Calame, K.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Science
- Published
- 1983-08-12
- Volume
- 221
- Issue
- 4611
- Pages
- 663-665
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002397775
- Cited by
- 152
- References
- 31
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 4 · 2019: 4 · 2018: 2 · 2016: 3 · 2015: 1 · 2014: 1
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Keywords
- enhancers, immunoglobulin heavy chain locus, SV40 early promoter, c-myc oncogene, plasmacytoma, immunoglobulin gene rearrangement, mice
- MeSH terms
- Animals, Cloning, Molecular, Gene Expression Regulation, Genetic Vectors, Immunoglobulin Heavy Chains, Operon, Simian virus 40, Transcription, Genetic, Transfection, Mice
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