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Cited by 758

The DOI matches its Crossref record.

Transport of Energy in Muscle: The Phosphorylcreatine Shuttle

Bessman, Samuel P., Geiger, Paul J.·1981·Science
DOI 10.1126/science.6450446
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Abstract

In order to explain the insulin-like effect of exercise, it was proposed in 1951 that contracting muscle fibers liberate creatine, which acts to produce an acceptor effect—later called respiratory control—on the muscle mitochondria. The development of this notion paralleled the controversy between biochemists and physiologists over the delivery of energy for muscle contraction. With the demonstration of functional compartmentation of creatine kinase on the mitochondrion, it became clear that the actual form of energy transport in the muscle fiber is phosphorylcreatine. The finding of an isoenzyme of creatine phosphokinase attached to the M-line region of the myofibril revealed the peripheral receptor for the mitochondrially generated phosphorylcreatine. This established a molecular basis for a phosphorylcreatine-creatine shuttle for energy transport in heart and skeletal muscle and provided an explanation for the inability to demonstrate experimentally a direct relation between muscle activity and the concentrations of adenosine triphosphate and adenosine diphosphate.

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Metadata

Authors
Bessman, S. P., & Geiger, P. J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1981-01-30
Volume
211
Issue
4481
Pages
448-452
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.6450446
OpenAlex
W2028436089
Cited by
758
References
0
FWCI
10.83
Type
journal article
Language
en
Open access
closed

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