The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Replication Timing of Genes and Middle Repetitive Sequences
Abstract
DNA replication in mammals is temporally bimodal. "Housekeeping" genes, which are active in all cells, replicate during the first half of the S phase of cell growth. Tissue-specific genes replicate early in those cells in which they are potentially expressed, and they usually replicate late in tissues in which they are not expressed. Replication during the first half of the S phase is, therefore, a necessary but not sufficient condition for gene transcription. A change in the replication timing of a tissue-specific gene appears to reflect the commitment of that gene to transcriptional competence or to quiescence during ontogeny. Most families of middle repetitive sequences replicate either early or late. These data are consistent with a model in which two functionally distinct genomes coexist in the nucleus.
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Cites
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,249
A rapid boiling method for the preparation of bacterial plasmids
Holmes, D. S., & Quigley, M. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90473-5 · Cited by 3,265
Britten, R. J., & Davidson, E. H. (1969) · Science · doi:10.1126/science.165.3891.349 · Cited by 2,064
Cleveland, D. W., Lopata, M. A., MacDonald, R. J., Cowan, N. J., Rutter, W. J., & Kirschner, M. W. (1980) · Cell · doi:10.1016/0092-8674(80)90238-x · Cited by 1,835
Kafatos, F. C., Jones, C. W., & Efstratiadis, A. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1541 · Cited by 1,360
Schibler, U., Wyler, T., & Hagenbüchle, O. (1975) · Journal of Molecular Biology · doi:10.1016/0022-2836(75)90217-x · Cited by 1,188
Expression of human immune interferon cDNA in E. coli and monkey cells
Gray, P. W., Leung, D. W., Pennica, D., Yelverton, E., Najarian, R., Simonsen, C. C., Derynck, R., Sherwood, P. J., Wallace, D. M., Berger, S. L., et al. (1982) · Nature · doi:10.1038/295503a0 · Cited by 689
Erythroleukemic Differentiation
Marks, P. A., & Rifkind, R. A. (1978) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.47.070178.002223 · Cited by 680
Highly Repeated Sequences in Mammalian Genomes
Singer, M. F. (1982) · International Review of Cytology · doi:10.1016/s0074-7696(08)61789-1 · Cited by 647
Regulation of Gene Expression: Possible Role of Repetitive Sequences
Davidson, E. H., & Britten, R. J. (1979) · Science · doi:10.1126/science.451548 · Cited by 568
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
The mosaic genome of warm-blooded vertebrates
Bernardi, G., Olofsson, B., Filipski, J., Zerial, M., Salinas, J., Cuny, G., Meunier-Rotival, M., & Rodier, F. (1985) · Science · doi:10.1126/science.4001930 · Cited by 875
Mouse centric and pericentric satellite repeats form distinct functional heterochromatin
Guenatri, M., Bailly, D., Maison, C., & Almouzni, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403109 · Cited by 498
Initiation of DNA replication at CpG islands in mammalian chromosomes
Delgado, S., Gómez, M., Bird, A., & Antequera, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2426 · Cited by 242
Evolution of chromosome bands: molecular ecology of noncoding DNA
Holmquist, G. P. (1989) · Journal of Molecular Evolution · doi:10.1007/bf02602928 · Cited by 177
Self-citation
Metadata
- Authors
- Goldman, M. A., Holmquist, G. P., Gray, M. C., Caston, L. A., & Nag, A.
- Venue
- Science
- Published
- 1984-05-18
- Volume
- 224
- Issue
- 4650
- Pages
- 686-692
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2053374394
- Cited by
- 538
- References
- 51
- FWCI
- 13.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goldman, M. A., Holmquist, G. P., Gray, M. C., Caston, L. A., & Nag, A. (1984). Replication Timing of Genes and Middle Repetitive Sequences. Science. https://doi.org/10.1126/science.6719109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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