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Gene Regulation for Higher Cells: A Theory: New facts regarding the organization of the genome provide clues to the nature of gene regulation.

Britten, Roy J., Davidson, Eric H.·1969·Science
DOI 10.1126/science.165.3891.349
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Abstract

Cell differentiation is based almost certainly on the regulation of gene activity, so that for each state of differentiation a certain set of genes is active in transcription and other genes are inactive. The establishment of this concept (1) has depended on evidence \nindicating that the cells of an organism generally contain identical genomes (2). Direct support for the idea that regulation of gene activity underlies cell differentiation \ncomes from evidence that much of the genome in higher cell \ntypes is inactive (3) and that different ribonucleic acids (RNA) are synthesized in different cell types (4).

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Metadata

Authors
Britten, R. J., & Davidson, E. H.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1969-07-25
Volume
165
Issue
3891
Pages
349-357
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.165.3891.349
OpenAlex
W2010916267
Cited by
2,064
References
1
FWCI
43.64
Type
journal article
Language
en
Open access
closed

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Britten, R. J., & Davidson, E. H. (1969). Gene Regulation for Higher Cells: A Theory: New facts regarding the organization of the genome provide clues to the nature of gene regulation. Science. https://doi.org/10.1126/science.165.3891.349

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