Cited by 3,627Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

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Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, PJ, Price, DL, Struble, RG, Clark, AW, Coyle, JT, DeLong, Mahlon R.·1982·Science

DOI 10.1126/science.7058341

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Abstract

Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. Postmortem studies have previously demonstrated profound reduction in the presynaptic markers for cholinergic neurons in the cortex of patients with Alzheimer's disease and senile dementia of the Alzheimer's type. The results of this study show that neurons of the nucleus basalis of Meynert undergo a profound (greater than 75 percent) and selective degeneration in these patients and provide a pathological substrate of the cholinergic deficiency in their brains. Demonstration of selective degeneration of such neurons represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and, as such, points to a critical subcortical lesion in Alzheimer's patients.

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SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736
Self-citation
APRIORITY
Asher, R. (1961) · The Lancet · doi:10.1016/s0140-6736(61)91217-x · Cited by 1,293
Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
Krettek, J. E., & Price, J. L. (1978) · Journal of Comparative Neurology · doi:10.1002/cne.901780204 · Cited by 1,293
The connections of the septal region in the rat
Swanson, L. W., & Cowan, W. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901860408 · Cited by 1,136
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120
HIPPOCAMPAL PROJECTIONS AND RELATED NEURAL PATHWAYS TO THE MID-BRAIN IN THE CAT
Nauta, W. J. H. (1958) · Brain · doi:10.1093/brain/81.3.319 · Cited by 990
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Activity of pallidal neurons during movement.
DeLong, M. R. (1971) · Journal of Neurophysiology · doi:10.1152/jn.1971.34.3.414 · Cited by 734
Self-citation
Neurotransmitter enzyme abnormalities in senile dementia
Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90073-9 · Cited by 724

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Show all 44 references

Research works printed but not linked: 10

Brody, H., Alzheimer's Disease: Senile Dementia and Related Disorders 7: 345 (1978).
Coyle, J. T., Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders: 149 (1981).
DAVIS, K.L., BRAIN ACETYLCHOLINE: 205 (1979).
DRACHMAN, D.A., AGING 7: 141 (1978).
HASSLER, R, BEHAV AGING NERVOUS: 284 (1965).
KUHAR, M.J., BIOL CHOLINERGIC FUN: 3 (1976).
PARENT, A, ADVANCES IN NEUROLOGY 24: 1 (1979).
TOMLINSON, B.E., DEMENTIA: 113 (1977).
WANG, H, AGING DEMENTIA: 1 (1977).
WANG, H.S., REPORT PANEL INFLAMM: 61 (1979).

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Ginsberg, S. D., Mufson, E. J., Alldred, M. J., Counts, S., Wuu, J., Nixon, R. A., & Che, S. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.05.012 · Cited by 132
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Irmak, S. O., & de Lecea, L. (2014) · SLEEP · doi:10.5665/sleep.4246 · Cited by 138
Personality Alterations in Dementia of the Alzheimer Type
Petry, S. D., Cummings, J. L., Hill, M. A., & Shapira, J. S. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520350025009 · Cited by 131
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Price, D. L., & Sisodia, S. S. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.435 · Cited by 132
Self-citation
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Salmon, D. P., Butters, N., & Chan, A. S.-Y. (1999) · Canadian Journal of Experimental Psychology/Revue canadienne de psychologie expérimentale · doi:10.1037/h0087303 · Cited by 140
A cytoarchitectonic and histochemical study of nucleus basalis and associated cell groups in the normal human brain
Saper, C. B., & Chelimsky, T. C. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90286-0 · Cited by 131
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Scopolamine amnesia of passive avoidance: A deficit of information acquisition
Rush, D. K. (1988) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(88)90938-7 · Cited by 131
Neurotransmitters in the cerebral cortex
Jones, E. G. (1986) · Journal of neurosurgery · doi:10.3171/jns.1986.65.2.0135 · Cited by 131
Retrograde changes in the nucleus basalis of the rat, caused by cortical damage, are prevented by exogenous ganglioside GM1
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Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
Kampmann, M. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00806-0 · Cited by 142
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Naoi, M., Maruyama, W., Dostert, P., et al. (1996) · Brain Research · doi:10.1016/0006-8993(95)01325-3 · Cited by 130
Neuronal responses related to reinforcement in the primate basal forebrain
Wilson, F. A. W., & Rolls, E. T. (1990) · Brain Research · doi:10.1016/0006-8993(90)90546-n · Cited by 130
Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors
Ávila, J., Wandosell, F. G., & Hernández, F. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.40 · Cited by 139
Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons
O’Meara, G. F., Coumis, U., Ma, S. Y., Kehr, J., Mahoney, S., Bacon, A., Allen, S. J., Holmes, F. E., Kahl, U., Wang, F. H., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.210254597 · Cited by 130
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Palmer, A. M., Francis, P. T., Bowen, D. M., Benton, J. S., Neary, D., Mann, D. M. A., & Snowden, J. S. (1987) · Brain Research · doi:10.1016/0006-8993(87)90018-7 · Cited by 130
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Decker, M. W., & Gallagher, M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90179-x · Cited by 130
Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease
Goedert, M., Fine, A., Dawbarn, D., Wilcock, G. K., & Chao, M. V. (1989) · Molecular Brain Research · doi:10.1016/0169-328x(89)90011-9 · Cited by 130
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sanchez-Varo, R. M., Mejias‐Ortega, M., Fernandez-Valenzuela, J. J., Nuñez‐Diaz, C., Cáceres-Palomo, L., Vegas‐Gomez, L., Sánchez‐Mejías, E., Trujillo‐Estrada, L., García‐León, J. A., Moreno‐González, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105404 · Cited by 136
Cholinergic activity and amyloid precursor protein metabolism
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Reyes, A. E., Chacón, M. A., Dinamarca, M. C., Cerpa, W. F., Morgan, C., & Inestrosa, N. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63774-1 · Cited by 129
Basal nucleus of meynert
Tagliavini, F., & Pilleri, G. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90203-4 · Cited by 128
Estrogen and Nerve Growth Factor‐related Systems in Brain
Gibbs, R. B. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb55792.x · Cited by 129
Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze
Sundström, E., Archer, T., Melander, T., & Hökfelt, T. G. M. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90233-9 · Cited by 127
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A correlated light and electron microscopic study of identified cholinergic basal forebrain neurons that project to the cortex in the rat
Ingham, C. A., Bolam, J. P., Wainer, B. H., & Smith, A. D. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902390205 · Cited by 127
Dementia
Chui, H. C. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520430102025 · Cited by 127
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Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons
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Retrograde cell degeneration in the basal nucleus in monkey and man
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Williams, S. R., & Fletcher, L. N. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.035 · Cited by 128
Cortical distribution of gangliosides in Alzheimer's disease
Kraĉun, I., Bognar, S. K., Talan-Hranilović, J., & Ćosović, Č. (1992) · Neurochemistry International · doi:10.1016/0197-0186(92)90058-y · Cited by 125
The Choline Transporter Resurfaces: New Roles for Synaptic Vesicles?
Ferguson, S. M. (2004) · Molecular Interventions · doi:10.1124/mi.4.1.22 · Cited by 129
Serotonin and acetylcholine release response in the rat hippocampus during a spatial memory task
Stancampiano, R., Cocco, S., Cugusi, C., Sarais, L., & Fadda, F. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00397-2 · Cited by 126
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Tuszynski, M. H. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00006-6 · Cited by 125
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Ingham, C. A., Bolam, J. P., & Smith, A. D. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902730210 · Cited by 124
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Nardone, R., Tezzon, F., Höller, Y., Golaszewski, S., Trinka, E., & Brigo, F. (2014) · Acta Neurologica Scandinavica · doi:10.1111/ane.12223 · Cited by 118
Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts
Zbesko, J. C., Nguyen, T. V., Yang, T., Frye, J. B., Hussain, O. M., Hayes, M. I., Chung, A. G., Day, W. A., Stepanovic, K., Krumberger, M., et al. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.007 · Cited by 128
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Tang, X. C., & Han, Y. (1999) · CNS Drug Reviews · doi:10.1111/j.1527-3458.1999.tb00105.x · Cited by 124
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Morris, A. W. J., Carare, R. O., Schreiber, S., & Hawkes, C. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00251 · Cited by 131
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Lockrow, J. P., Prakasam, A., Huang, P., Bimonte‐Nelson, H. A., Sambamurti, K., & Granholm, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.11.021 · Cited by 126
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The bed nucleus‐amygdala continuum in human and monkey
Price, D. L., Martin, L. J., Powers, R. E., & Dellovade, T. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903090404 · Cited by 123
Self-citation
A comparison of changes in the nucleus basalis and locus caeruleus in Alzheimer's disease.
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.47.2.201 · Cited by 123
Amyloid-β, tau, and the cholinergic system in Alzheimer’s disease: seeking direction in a tangle of clues
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Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses
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Pharmacological Treatment of Alzheimer Disease
Massoud, F., & Léger, G. C. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105601003 · Cited by 130
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Haense, C., Kalbe, E., Herholz, K., Hohmann, C., Neumaier, B., Krais, R., & Heiss, W. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.015 · Cited by 127
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Rahim, F., Ullah, H., Taha, M., Wadood, A., Javed, M. T., Rehman, W. U., Nawaz, M., Ashraf, M., Ali, M., Sajid, M., et al. (2016) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2016.07.005 · Cited by 121
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Wong, K. Y., Roy, J., Fung, M., Heng, B. C., Zhang, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.1125 · Cited by 122
Current therapeutic targets for the treatment of Alzheimer’s disease
Grill, J. D., & Cummings, J. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.29 · Cited by 123
In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: Thin layer chromatography versus microplate methods
Giovanni, S. D., Borloz, A., Urbain, A., Marston, A., Hostettmann, K., Carrupt, P., & Reist, M. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.10.004 · Cited by 121
The decline in synapses and cholinergic activity is asynchronous in Alzheimer’s disease
Tiraboschi, P., Hansen, L. A., Alford, M. F., Masliah, E., Thal, L. J., & Corey‐Bloom, J. (2000) · Neurology · doi:10.1212/wnl.55.9.1278 · Cited by 122
Basal forebrain infarction. A clinicopathologic correlation.
Phillips, S., Sangalang, V., & Sterns, G. L. (1987) · Archives of Neurology · doi:10.1001/archneur.1987.00520230024008 · Cited by 121
Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus
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Neural Transplantation in Animal Models of Dementia
Dunnett, S. B. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00448.x · Cited by 119
The dendritic hypothesis for Alzheimer's disease pathophysiology
Cochran, J. N., Hall, A. M., & Roberson, E. D. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.12.004 · Cited by 114
Neural and cognitive plasticity: From maps to minds.
Mercado, E. (2008) · Psychological Bulletin · doi:10.1037/0033-2909.134.1.109 · Cited by 128
Maternal choline supplementation improves spatial learning and adult hippocampal neurogenesis in the Ts65Dn mouse model of Down syndrome
Velázquez, R., Ash, J. A., Powers, B. E., Kelley, C. M., Strawderman, M. S., Luscher, Z. I., Ginsberg, S. D., Mufson, E. J., & Strupp, B. J. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.016 · Cited by 124
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Wilson, F., & Rolls, E. T. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-04-01254.1990 · Cited by 120
The cholinergic system of the human hindbrain studied by choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry
Mizukawa, K., McGeer, P. L., Tago, H., Peng, J. H., McGeer, E. G., & Kimura, H. (1986) · Brain Research · doi:10.1016/0006-8993(86)90253-2 · Cited by 120
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Semick, S. A., Bharadwaj, R. A., Collado‐Torres, L., Tao, R., Shin, J. H., Deep‐Soboslay, A., Weiss, J. R., Weinberger, D. R., Hyde, T. M., Kleinman, J. E., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01966-5 · Cited by 121
Adeno-Associated Viral Vectors in Neuroscience Research
Haggerty, D. L., Grecco, G. G., Reeves, K. C., & Atwood, B. K. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2019.11.012 · Cited by 135
Neurobiochemical Cross-talk Between COVID-19 and Alzheimer’s Disease
Rahman, M. A., Islam, K., Rahman, S., & Alamin, M. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02177-w · Cited by 121
Acetylcholinesterase and butyrylcholinesterase in frontal cortex and cerebrospinal fluid of demented and non-demented patients with Parkinson's disease
Ruberg, M., Rieger, F., Villageois, A. P., Bonnet, A. M., & Agid, Y. (1986) · Brain Research · doi:10.1016/0006-8993(86)91401-0 · Cited by 119
Cholinergic Involvement in Alzheimer’s Disease. A Link with NGF Maturation and Degradation
Cuello, A. C., Bruno, M. A., Allard, S., León, W., & Iulita, M. F. (2009) · Journal of Molecular Neuroscience · doi:10.1007/s12031-009-9238-z · Cited by 119
Design and evaluation of radioactive acetylcholine analogs for mapping brain acetylcholinesterase (AchE) in vivo
Irie, T., Fukushi, K., Akimoto, Y., et al. (1994) · Nuclear Medicine and Biology · doi:10.1016/0969-8051(94)90159-7 · Cited by 119
Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia
Arai, H., Emson, P. C., Mountjoy, C. Q., Carassco, L. H., & Heizmann, C. W. (1987) · Brain Research · doi:10.1016/0006-8993(87)90974-7 · Cited by 118
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Castle, M. J., Baltanás, F. C., Kovács, I., Nagahara, A. H., Barba, D., & Tuszynski, M. H. (2020) · Human Gene Therapy · doi:10.1089/hum.2019.367 · Cited by 117
Muscarinic Tone Sustains Impulse Flow in the Septohippocampal GABA But Not Cholinergic Pathway: Implications for Learning and Memory
Alreja, M., Wu, M., Liu, W., Atkins, J. B., Léránth, C., & Shanabrough, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08103.2000 · Cited by 118
Brain aging and Alzheimer's disease; use it or lose it
Swaab, D. F., Dubelaar, E. J. G., Hofman, M. A., Scherder, E., Someren, E. J. W. V., & Verwer, R. W. H. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)38086-5 · Cited by 119
Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann‐Pick C disease
German, D. C., Quintero, E. M., Liang, C., Ng, B., Punia, S., Xie, C., & Dietschy, J. M. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1149 · Cited by 118
Long-Lasting Cholinergic Modulation Underlies Rule Learning in Rats
Saar, D., Grossman, Y. R., & Barkai, E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01385.2001 · Cited by 118
Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats
Itoh, A., Akaike, T., Sokabe, M., Nitta, A., Iida, R., Olariu, A., Yamada, K., & Nabeshima, T. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00601-9 · Cited by 122
Changes in nerve cells of the nucleus basalis of Meynert in Alzheimer's disease and their relationship to ageing and to the accumulation of lipofuscin pigment
Mann, D. M. A., Yates, P. O., & Marcyniuk, B. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90140-4 · Cited by 118
Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.
Wallace, W., Ahlers, S. T., Gotlib, J. R., Bragin, V., Sugar, J., Gluck, R., SHEA, P. A., Davis, K. L., & Haroutunian, V. H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8712 · Cited by 118
Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment
Koh, S., Chang, P., Collier, T. J., & Loy, R. (1989) · Brain Research · doi:10.1016/0006-8993(89)91125-6 · Cited by 118
Optogenetic Dissection of the Basal Forebrain Neuromodulatory Control of Cortical Activation, Plasticity, and Cognition
Lin, S., Brown, R. E., Shuler, M. G. H., Petersen, C. C. H., & Kepecs, Á. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2590-15.2015 · Cited by 115
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients
Kordower, J. H., Gash, D. M., Bothwell, M. A., Hersh, L. B., & Mufson, E. J. (1989) · Neurobiology of Aging · doi:10.1016/s0197-4580(89)80013-2 · Cited by 117
A galanin-like peptide coexists in putative cholinergic somata of the septum-basal forebrain complex and in acetylcholinesterase-containing fibers and varicosities within the hippocampus in the owl monkey (aotus trivirgatus)
Melander, T., & Staines, W. A. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90222-3 · Cited by 117
Isl1 Directly Controls a Cholinergic Neuronal Identity in the Developing Forebrain and Spinal Cord by Forming Cell Type-Specific Complexes
Cho, H.-H., Cargnin, F., Kim, Y., Lee, B., Kwon, R.-J., Nam, H., Shen, R., Barnes, A. P., Lee, J. W., Lee, S., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004280 · Cited by 116
Extrinsic afferent systems to the dentate gyrus
Léránth, C., & Hajszán, T. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63004-0 · Cited by 120
Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease.
Kordower, J. H., Charles, V., Bayer, R. A., Bartus, R. T., Putney, S. D., Walus, L. R., & Friden, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.9077 · Cited by 116
Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated trka expression in the medial septum of aged rats
Cooper, J. D., Lindholm, D., & Sofroniew, M. V. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90462-6 · Cited by 116
Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.
Martı́nez-Serrano, A., Fischer, W., Söderström, S., Ebendal, T., & Björklund, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6355 · Cited by 116
Pharmacological alleviation of cholinergic lesion induced memory deficits in rats
Haroutunian, V. H., Kanof, P. D., & Davis, K. L. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90531-4 · Cited by 116
Impairment in T-maze reinforced alternation performance following nucleus basalis magnocellularis lesions in rats
Salamone, J. D., Beart, P. M., Alpert, J. E., & Iversen, S. D. (1984) · Behavioural Brain Research · doi:10.1016/0166-4328(84)90030-5 · Cited by 116
Amyloid-β oligomers in cellular models of Alzheimer’s disease
Fontana, I. C., Zimmer, A. R., Rocha, A. S., Gosmann, G., Souza, D. O., Lourenco, M. V., Ferreira, S. T., & Zimmer, E. R. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15030 · Cited by 115
Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction
Park, D., Lee, H. J., Joo, S. S., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.12.040 · Cited by 115

Authors: Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R.
Affiliations: Johns Hopkins University (US)
Neuropathology Laboratory, Departments of Pathology and Neurology, Baltimore, Maryland 21205
Departments of Pharmacology and Experimental Therapy, Psychiatry, and Neuroscience, Baltimore, Maryland 21205
ORCID: DeLong, Mahlon R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1982-03-05
Volume: 215
Issue: 4537
Pages: 1237-1239
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.7058341
OpenAlex: W2093374391
Semantic Scholar: e0380e88fdffd5a546eb76a1d2eb7d05db143f94
Cited by: 3,627
References: 44
Citations by year: 2026: 52 · 2025: 42 · 2024: 53 · 2023: 67 · 2022: 62 · 2021: 91 · 2020: 95 · 2019: 66 · 2018: 63 · 2017: 66 · 2016: 82 · 2015: 65 · 2014: 73 · 2013: 63 · 2012: 56
FWCI: 110.00
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, senile dementia, nucleus basalis of Meynert, basal forebrain, cholinergic neurons, neuronal loss, cholinergic deficit, cerebral cortex, presynaptic markers, subcortical lesions
MeSH terms: Acetylcholine, Alzheimer Disease, Basal Ganglia, Dementia, Humans, Neural Pathways

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Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

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