Cited by 3,627Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, PJ, Price, DL, Struble, RG, Clark, AW, Coyle, JT, DeLong, Mahlon R.·1982·Science

DOI 10.1126/science.7058341

Open this paper in CoChat — free account

Abstract

Recent evidence indicates that the nucleus basalis of Meynert, a distinct population of basal forebrain neurons, is a major source of cholinergic innervation of the cerebral cortex. Postmortem studies have previously demonstrated profound reduction in the presynaptic markers for cholinergic neurons in the cortex of patients with Alzheimer's disease and senile dementia of the Alzheimer's type. The results of this study show that neurons of the nucleus basalis of Meynert undergo a profound (greater than 75 percent) and selective degeneration in these patients and provide a pathological substrate of the cholinergic deficiency in their brains. Demonstration of selective degeneration of such neurons represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and, as such, points to a critical subcortical lesion in Alzheimer's patients.

Integrity signals

Registry

Crossref · 10.1126/science.7058341

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736
Self-citation
APRIORITY
Asher, R. (1961) · The Lancet · doi:10.1016/s0140-6736(61)91217-x · Cited by 1,293
Amygdaloid projections to subcortical structures within the basal forebrain and brainstem in the rat and cat
Krettek, J. E., & Price, J. L. (1978) · Journal of Comparative Neurology · doi:10.1002/cne.901780204 · Cited by 1,293
The connections of the septal region in the rat
Swanson, L. W., & Cowan, W. M. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901860408 · Cited by 1,136
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120
HIPPOCAMPAL PROJECTIONS AND RELATED NEURAL PATHWAYS TO THE MID-BRAIN IN THE CAT
Nauta, W. J. H. (1958) · Brain · doi:10.1093/brain/81.3.319 · Cited by 990
Some morphometric aspects of the brain in senile dementia of the alzheimer type
Terry, R. D., Peck, A., DeTeresa, R., Schechter, R., & Horoupian, D. S. (1981) · Annals of Neurology · doi:10.1002/ana.410100209 · Cited by 801
Activity of pallidal neurons during movement.
DeLong, M. R. (1971) · Journal of Neurophysiology · doi:10.1152/jn.1971.34.3.414 · Cited by 734
Self-citation
Neurotransmitter enzyme abnormalities in senile dementia
Perry, E. K., Gibson, P. H., Blessed, G., Perry, R. H., & Tomlinson, B. E. (1977) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(77)90073-9 · Cited by 724

Flagged first, then by citations

Show all 44 references

Research works printed but not linked: 10

Brody, H., Alzheimer's Disease: Senile Dementia and Related Disorders 7: 345 (1978).
Coyle, J. T., Brain Neurotransmitters and Receptors in Aging and Age-Related Disorders: 149 (1981).
DAVIS, K.L., BRAIN ACETYLCHOLINE: 205 (1979).
DRACHMAN, D.A., AGING 7: 141 (1978).
HASSLER, R, BEHAV AGING NERVOUS: 284 (1965).
KUHAR, M.J., BIOL CHOLINERGIC FUN: 3 (1976).
PARENT, A, ADVANCES IN NEUROLOGY 24: 1 (1979).
TOMLINSON, B.E., DEMENTIA: 113 (1977).
WANG, H, AGING DEMENTIA: 1 (1977).
WANG, H.S., REPORT PANEL INFLAMM: 61 (1979).

Sorted by citations

Items 801–900 of 1,021

Reaction Time and Vigilance in Parkinson's Disease
Stern, Y. (1984) · Archives of Neurology · doi:10.1001/archneur.1984.04050210084021 · Cited by 87
Differentiation of Alzheimer's Disease and Huntington's Disease With the Dementia Rating Scale
Salmon, D. P., Kwo-On-Yuen, P. F., Heindel, W. C., et al. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520470060028 · Cited by 87
Dementia and Parkinson's Disease
Gibb, W. R. G. (1989) · The British Journal of Psychiatry · doi:10.1192/bjp.154.5.596 · Cited by 87
Fine structure of rat septohippocampal neurons: II. A time course analysis following axotomy
Naumann, T., Peterson, G. M., & Frotscher, M. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250207 · Cited by 87
Effects of bilateral ibotenate-induced lesions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex
Watson, M., Vickroy, T. W., Fibiger, H. C., Roeske, W. R., & Yamamura, H. I. (1985) · Brain Research · doi:10.1016/0006-8993(85)90876-5 · Cited by 87
Acetyl-l-carnitine for dementia
Hudson, S. A., & Tabet, N. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003158 · Cited by 86
Nicotine Prevents Synaptic Impairment Induced by Amyloid-β Oligomers Through α7-Nicotinic Acetylcholine Receptor Activation
Inestrosa, N. C., Godoy, J. A., Vargas, J., Arrázola, M. S., Ríos, J. A., Carvajal, F. J., Serrano, F. G., & Farı́as, G. G. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8242-1 · Cited by 89
EEG Coherence in Pathological Conditions
Leocani, L., & Comı, G. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199911000-00006 · Cited by 86
Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors
Hedrick, T. P., & Waters, J. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00716.2014 · Cited by 92
Role of GSK‐3β in Alzheimer's disease pathology
Planel, E., Sun, X., & Takashima, A. (2002) · Drug Development Research · doi:10.1002/ddr.10100 · Cited by 87
Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention
Fadel, J. R., & Burk, J. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.046 · Cited by 89
Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats
Mandel, R. J., & Thal, L. J. (1988) · Psychopharmacology · doi:10.1007/bf00216074 · Cited by 85
Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments
Bürger, C., López, M. C., Feller, J. A., Baker, H. V., Muzyczka, N., & Mandel, R. J. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.05.003 · Cited by 85
Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice
Ash, J. A., Velázquez, R., Kelley, C. M., Powers, B. E., Ginsberg, S. D., Mufson, E. J., & Strupp, B. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.06.001 · Cited by 88
Alzheimers Disease: Interactions Between Cholinergic Functions and β- amyloid
Yan, Z., & Feng, J. (2004) · Current Alzheimer Research · doi:10.2174/1567205043331992 · Cited by 84
Differential deregulation of NGF and BDNF neurotrophins in a transgenic rat model of Alzheimer's disease
Iulita, M. F., Millón, M. B. B., Pentz, R., Aguilar, L. F., Carmo, S. D., Allard, S. T. M., Michalski, B., Wilson, E. N., Ducatenzeiler, A., Bruno, M. A., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.019 · Cited by 87
Long-term actions of vector-derived nerve growth factor or brain-derived neurotrophic factor on choline acetyltransferase and Trk receptor levels in the adult rat basal forebrain
Klein, R. L., Muir, D. F., King, M. A., Peel, A. L., Zolotukhin, S., Möller, J. C., Krüttgen, A., Heymach, J. V., Muzyczka, N., & Meyer, E. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00537-5 · Cited by 84
Differential effects of aging and Alzheimer's disease on conceptual implicit and explicit memory.
Monti, L. A., Gabrieli, J. D. E., Reminger, S. L., Rinaldi, J., Wilson, R. S., & Fleischman, D. A. (1996) · Neuropsychology · doi:10.1037/0894-4105.10.1.101 · Cited by 87
NGF gene transfer to intrinsic basal forebrain neurons increases cholinergic cell size and protects from age-related, spatial memory deficits in middle-aged rats
Klein, R. L., Hirko, A. C., Meyers, C., Grimes, J. R., Muzyczka, N., & Meyer, E. M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02634-2 · Cited by 84
Increasing Required Neural Response to Expose Abnormal Brain Function in Mild Versus Moderate or Severe Alzheimer's Disease: PET Study Using Parametric Visual Stimulation
Mentis, M. J., Alexander, G. E., Krasuski, J., Pietrini, P., Furey, M. L., Schapiro, M. B., & Rapoport, S. I. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.785 · Cited by 85
A correlated light and electron microscopic immunocytochemical study of cholinergic terminals and neurons in the rat amygdaloid body with special emphasis on the basolateral amygdaloid nucleus
Carlsen, J., & Heimer, L. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902440110 · Cited by 84
NEURONAL COUNTS IN BASAL NUCLEUS OF MEYNERT IN ALZHEIMER DISEASE AND IN SIMPLE SENILE DEMENTIA
Tagliavini, F., & Pilleri, G. (1983) · The Lancet · doi:10.1016/s0140-6736(83)91462-9 · Cited by 84
Transplantation of embryonic ventral forebrain neurons to the neocortex of rats with lesions of nucleus basalis magnocellularis—I. Biochemical and anatomical observations
Fine, A., Dunnett, S. B., Björklund, A., Clarke, D. J., & Iversen, S. D. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90093-4 · Cited by 84
Decreased Expression of Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein mRNA in the Hippocampus in Alzheimer Disease
Maki, M., Matsukawa, N., Yuasa, H., Otsuka, Y., Yamamoto, T., Akatsu, H., Okamoto, T., Ueda, R., & Ojika, K. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.2.176 · Cited by 83
Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn down syndrome mouse model
Choi, J. H. K., Berger, J. D., Mazzella, M. J., Morales‐Corraliza, J., Cataldo, A. M., Nixon, R. A., Ginsberg, S. D., Levy, E., & Mathews, P. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06277.x · Cited by 83
Executive Dysfunction in MCI: Subtype or Early Symptom
Reinvang, I., Grambaitė, R., & Espeseth, T. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/936272 · Cited by 91
Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders
Kotagal, V., Müller, M. L. T. M., Kaufer, D., Koeppe, R. A., & Bohnen, N. I. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.02.083 · Cited by 82
Tropicamide effects on pupil size and pupillary light reflexes in Alzheimer's and Parkinson's disease
Granholm, E. L., Morris, S., Galasko, D. R., et al. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(02)00122-8 · Cited by 83
Chronic 1,25-dihydroxyvitamin D3-mediated induction of nerve growth factor mRNA and protein in L929 fibroblasts and in adult rat brain
Saporito, M. S., Brown, E. R., Hartpence, K. C., Wilcox, H. M., Vaught, J. L., & Carswell, S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91539-3 · Cited by 83
Role of GABA during the multiple consolidation of memory
Brioni, J. D. (1993) · Drug Development Research · doi:10.1002/ddr.430280103 · Cited by 83
Experimental Therapeutics of Neurodegenerative Disorders: Unmet Needs
Shoulson, I. (1998) · Science · doi:10.1126/science.282.5391.1072 · Cited by 82
Restoration of cholinomimetic activity by clonidine in cholinergic plus noradrenergic lesioned rats
Haroutunian, V. H., Kanof, P. D., Tsuboyama, G. K., & Davis, K. L. (1990) · Brain Research · doi:10.1016/0006-8993(90)90280-o · Cited by 83
Galanin and NADPH-diaphorase coexistence in cholinergic neurons of the rat basal forebrain
Pasqualotto, B. A., & Vincent, S. R. (1991) · Brain Research · doi:10.1016/0006-8993(91)90916-j · Cited by 83
Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures
Sirenko, O., Parham, F., Dea, S., Sodhi, N., Biesmans, S., Mora-Castilla, S., Ryan, K., Behl, M., Chandy, G., Crittenden, C., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy218 · Cited by 84
Partial agonistic effect of yokukansan on human recombinant serotonin 1A receptors expressed in the membranes of Chinese hamster ovary cells
Terawaki, K., Ikarashi, Y., Sekiguchi, K., et al. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.11.003 · Cited by 82
Ca2+ Permeable AMPA Channels in Diseases of the Nervous System
Weiss, J. H. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00042 · Cited by 83
Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type
Meador, K. J., Loring, D. W., Nichols, M., ZAMRINI, E. Y., Rivner, M. H., Posas, H. N., Thompson, E. E., & Moore, E. (1993) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879300600408 · Cited by 82
Protective effect of quercetin against ICV colchicine‐induced cognitive dysfunctions and oxidative damage in rats
Kumar, A., Sehgal, N., Kumar, P., et al. (2008) · Phytotherapy Research · doi:10.1002/ptr.2454 · Cited by 82
Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F β-amyloid precursor protein — initial observations
Diez, M., Koıstınaho, J., Kahn, K., Games, D., & Hökfelt, T. G. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00261-x · Cited by 81
Schizophrenia and Alzheimer's disease: Clinical and pathophysiologic analogies
White, K. E., & Cummings, J. L. (1996) · Comprehensive Psychiatry · doi:10.1016/s0010-440x(96)90035-8 · Cited by 82
The basal nucleus of Meynert in patients with progressive supranuclear palsy
Tagliavini, F., Pilleri, G., Bouras, C., & Constantinidis, J. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90217-9 · Cited by 82
Basal forebrain—lesioned monkeys are severely impaired in tasks of association and recognition memory
Irle, E., & Markowitsch, H. J. (1987) · Annals of Neurology · doi:10.1002/ana.410220610 · Cited by 82
Neuropeptide gene expression in brain is differentially regulated by midbrain dopamine neurons
Lindefors, N., Bren�, S., Herrera‐Marschitz, M., & Persson, H. (1990) · Experimental Brain Research · doi:10.1007/bf00227990 · Cited by 82
Anosognosia predicts default mode network hypometabolism and clinical progression to dementia
Therriault, J., Ng, K. P., Pascoal, T. A., Mathotaarachchi, S. S., Kang, M. S., Struyfs, H., Shin, M., Benedet, A. L., Walpola, I. C., Nair, V. P., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005120 · Cited by 79
Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain
Sato, A., Sato, Y., & Uchida, S. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00017-x · Cited by 81
Locus ceruleus degeneration is ubiquitous in Alzheimer’s disease: Possible implications for diagnosis and treatment
Haglund, M., Sjöbeck, M., & Englund, E. M. (2006) · Neuropathology · doi:10.1111/j.1440-1789.2006.00725.x · Cited by 81
Chronic Exposure to Dietary Sterol Glucosides is Neurotoxic to Motor Neurons and Induces an ALS–PDC Phenotype
Tabata, R. C., Wilson, J. M. B., Ly, P. T. T., et al. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8020-z · Cited by 81
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease
Palanimuthu, D., Poon, R., Sahni, S., Anjum, R., Hibbs, D. E., Lin, H.-Y. J., Bernhardt, P. V., Kalinowski, D. S., & Richardson, D. R. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.08.021 · Cited by 82
Transient fetal structure, the gangliothalamic body, connects telencephalic germinal zone with all thalamic regions in the developing human brain
Letini, K., & Kostovi, I. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970804)384:3 · Cited by 76
Runaway synaptic modification in models of cortex: Implications for Alzheimer's disease
Hasselmo, M. E. (1994) · Neural Networks · doi:10.1016/0893-6080(94)90053-1 · Cited by 80
Cholinergic markers in aged cognitively impaired long-evans rats
Aubert, I., Rowe, W. B., Meaney, M. J., Gauthier, S. G., & Quirion, R. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00056-o · Cited by 81
DuP 996 (3,3‐bis(4‐pyrindinylmethyl)‐1‐phenylindolin‐2‐one) enhances the stimulus‐induced release of acetylcholine from rat brain in vitro and in vivo
Nickolson, V. J., Tam, S. W., Myers, M. J., & Cook, L. (1990) · Drug Development Research · doi:10.1002/ddr.430190307 · Cited by 81
Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia
Ichimiya, Y., Arai, H., Kosaka, K., et al. (1986) · Acta Neuropathologica · doi:10.1007/bf00691428 · Cited by 81
Catecholaminergic neurites in senile plaques in prefrontal cortex of aged nonhuman primates
Kitt, C. A., Struble, R. G., Cork, L. C., Mobley, W. C., Walker, L. C., Joh, T. H., & Price, D. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90202-7 · Cited by 80
Self-citation
BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 are implicated in tau pathology
Taga, M., Petyuk, V. A., White, C., Marsh, G., Ma, Y., Klein, H.-U., Connor, S. M., Kroshilina, A., Yung, C. J., Khairallah, A., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00387-3 · Cited by 81
Alzheimer's Disease and Amyloid: Culprit or Coincidence?
Skaper, S. D. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-386986-9.00011-9 · Cited by 82
Activation of the intracerebral cholinergic nerve fibers originating in the basal forebrain increases regional cerebral blood flow in the rat's cortex and hippocampus
Sato, A., Sato, Y., & Uchida, S. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.004 · Cited by 80
The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.
Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Hughes, A. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.6.842 · Cited by 80
A complementary DNA for human choline acetyltransferase induces two forms of enzyme with different molecular weights in cultured cells
Oda, Y., Nakanishi, I., & Deguchi, T. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90237-6 · Cited by 80
A multicenter double-blind study of controlled-release physostigmine for the treatment of symptoms secondary to Alzheimer's disease
Thal, L. J., Schwartz, G. E., Sano, M. C., Weiner, M., Knopman, D. S., Harrell, L. E., Bodenheimer, S. L., Rossor, M. N., Philpot, M. P., Schor, J., et al. (1996) · Neurology · doi:10.1212/wnl.47.6.1389 · Cited by 80
Correlation between cortical plaque count and neuronal loss in the nucleus basalis in Alzheimer's disease
Arendt, T., Bigl, V., Tennstedt, A., & Arendt, A. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90292-1 · Cited by 80
Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents
Tilson, H. A., McLamb, R. L., Shaw, S., Rogers, B. C., Pediaditakis, P., & Cook, L. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)91326-1 · Cited by 81
Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage
Sofroniew, M. V., Ole Isacson, A., & Björklund, A. (1986) · Brain Research · doi:10.1016/0006-8993(86)90947-9 · Cited by 80
Simultaneous release of glutamate and acetylcholine from single magnocellular “cholinergic” basal forebrain neurons
Allen, T. G. J., Abogadie, F. C., & Brown, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3979-05.2006 · Cited by 79
N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
Martı́nez, A., Fernandez, E., Castro, A., Conde, S., Rodrı́guez-Franco, M. I., Baños, J.-E., & Badı́a, A. (2000) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(00)01166-1 · Cited by 79
Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies
Graff-Radford, J., Boeve, B. F., Pedraza, O., Ferman, T. J., Przybelski, S. A., Lesnick, T. G., Vemuri, P., Senjem, M. L., Smith, G. E., Knopman, D. S., et al. (2012) · Brain · doi:10.1093/brain/aws173 · Cited by 80
Acetylcholinesterase inhibitors for treating dementia symptoms - a safety evaluation
Mohammad, D., Chan, P., Bradley, J., Lanctôt, K. L., & Herrmann, N. (2017) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1351540 · Cited by 84
EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia
Gibson, P. H. (1983) · Acta Neuropathologica · doi:10.1007/bf00684929 · Cited by 79
The basal nucleus of Meynert in idiopathic Parkinson's disease
Tagliavini, F., Pilleri, G., Bouras, C., & Constantinidis, J. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1984.tb00798.x · Cited by 80
Methyl Analogues of the Experimental Alzheimer Drug Phenserine: Synthesis and Structure/Activity Relationships for Acetyl- and Butyrylcholinesterase Inhibitory Action
Yu, Q., Holloway, H. W., Flippen-Anderson, J. L., Hoffman, B., Brossi, A. R., & Greig, N. H. (2001) · Journal of Medicinal Chemistry · doi:10.1021/jm010080x · Cited by 79
Lifelong Estrogen Exposure and Cognitive Performance in Elderly Women
Smith, C. A., McCleary, C. A., Murdock, G. A., Wilshire, T. W., Buckwalter, D. K., Bretsky, P., MARMOL, L. M., Gorsuch, R. L., & Buckwalter, J. G. (1999) · Brain and Cognition · doi:10.1006/brcg.1999.1078 · Cited by 78
The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes
Privou, C., Knoche, A., Hasenöhrl, R. U., & Huston, J. P. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00087-2 · Cited by 78
Cholinergic modulation, visual function and Alzheimer's dementia
Nobili, L., & Sannita, W. G. (1997) · Vision Research · doi:10.1016/s0042-6989(97)00076-x · Cited by 78
Amyloid Precursor Protein in Platelets of Patients With Alzheimer Disease
Borroni, B., Colciaghi, F., Pastorino, L., Pettenati, C., Cottini, E., Rozzini, L., Monastero, R., Lenzi, G. L., Cattabeni, F., Luca, M. D., et al. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.442 · Cited by 79
Alzheimer's Disease and Other Dementing Disorders
Raskind, M. A., & Peskind, E. R. (1992) · Elsevier eBooks · doi:10.1016/b978-0-12-101277-9.50022-x · Cited by 77
Age- and sex-dependent development of adrenocortical hyperactivity in a transgenic mouse model of Alzheimer’s disease
Touma, C., Ambrée, O., Goertz, N., Keyvani, K., Lewejohann, L., Palme, R., Paulus, W., Schwarze-Eicker, K., & Sachser, N. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.004 · Cited by 78
P75 Neurotrophin Receptor in the Nucleus Basalis of Meynert in Relation to Age, Sex, and Alzheimer's Disease
Salehi, A., Ocampo, M., Verhaagen, J., & Swaab, D. F. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7252 · Cited by 77
Memory improvement without toxicity during chronic, low dose intravenous arecoline in Alzheimer's disease
Soncrant, T. T., Raffaele, K. C., Asthana, S., et al. (1993) · Psychopharmacology · doi:10.1007/bf02244889 · Cited by 77
The Potential for Muscarinic Receptor Subtype-Specific Pharmacotherapy for Alzheimer's Disease
McKinney, M., & Coyle, J. T. (1991) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62474-4 · Cited by 77
Self-citation
Current and Emerging Pharmacological Treatment Options for Dementia
Ringman, J. M., & Cummings, J. L. (2006) · Behavioural Neurology · doi:10.1155/2006/315386 · Cited by 77
Evaluation of cholinergic markers in Alzheimer's disease and in a model of cholinergic deficit
Gil-Bea, F. J., Garcı́a-Alloza, M., Domínguez, J., Marcos, B., & Ramírez, M. J. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.062 · Cited by 77
Neurogenesis of basal forebrain cholinergic neurons in rat
Brady, D. R., Phelps, P. E., & Vaughn, J. E. (1989) · Developmental Brain Research · doi:10.1016/0165-3806(89)90110-7 · Cited by 77
The Alzheimer amyloid precursor-related transcript lacking the β/A4 sequence is specifically increased in Alzheimer's disease brain
Neve, R. L., Rogers, J., & Higgins, G. A. (1990) · Neuron · doi:10.1016/0896-6273(90)90169-g · Cited by 76
Somatostatin- and Neuropeptide Y-immunoreactive neurons in the neocortex in senile dementia of alzheimer's type
Nakamura, S., & Vincent, S. R. (1986) · Brain Research · doi:10.1016/0006-8993(86)91099-1 · Cited by 78
Memory Performances in Young, Elderly, and Very Old Healthy Individuals versus Patients with Alzheimer's Disease: Evidence for Discontinuity Between Normal and Pathological Aging
Carlesimo, G. A., Mauri, M. F., Graceffa, A. M. S., et al. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.1.14.1482 · Cited by 76
Intact cannabinoid CB1 receptors in the Alzheimer's disease cortex
Lee, J. H., Agacinski, G., Williams, J. H., Wilcock, G. K., Esiri, M. M., Francis, P. T., Wong, P. T. ‐., Chen, C., & Lai, M. K. P. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.10.010 · Cited by 76
Vesicular Acetylcholine Transporter Density and Alzheimer’s Disease
Efange, S. M. N., Garland, E. M., Staley, J. K., Khare, A. B., & Mash, D. C. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00038-9 · Cited by 76
Single cell gene expression profiling in Alzheimer’s disease
Ginsberg, S. D., Che, S., Counts, S., & Mufson, E. J. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.05.007 · Cited by 76
Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats
Lacalle, S. D., Cooper, J. D., Svendsen, C. N., Dunnett, S. B., & Sofroniew, M. V. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00239-4 · Cited by 76
Cholinesterase inhibitors, β-amyloid precursor protein and amyloid β-peptides in Alzheimer's disease
Lahiri, D. K., Farlow, M. R., Hintz, N., Utsuki, T., & Greig, N. H. (2000) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2000.00309.x · Cited by 77
Cellular and Molecular Neuropathology of the Olfactory Epithelium and Central Olfactory Pathways in Alzheimer's Disease and Schizophreniaa
Arnold, S. E., Smutzer, G., Trojanowski, J. Q., & Moberg, P. J. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10656.x · Cited by 77
Preclinical development of neurosteroids as neuroprotective agents for the treatment of neurodegenerative diseases
Lapchak, P. A., & Araujo, D. M. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)46069-7 · Cited by 77
Further characterizations of the nature of the behavioral and neurochemical effects of lesions to the nucleus basalis of meynert in the rat
Altman, H. J., Crosland, R. D., Jenden, D. J., et al. (1985) · Neurobiology of Aging · doi:10.1016/0197-4580(85)90030-2 · Cited by 76
Cholinergic modulation of response gain in the primary visual cortex of the macaque
Soma, S., Shimegi, S., Osaki, H., & Sato, H. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00330.2011 · Cited by 75
Evidence for the existence of serotonin type-2 receptors on cholinergic terminals in rat cortex
Quirion, R., Richard, J., & Dam, T. V. (1985) · Brain Research · doi:10.1016/0006-8993(85)91590-2 · Cited by 88
Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease
Kulshreshtha, A., & Piplani, P. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2625-7 · Cited by 76
Mechanisms of ferroptosis in Alzheimer's disease and therapeutic effects of natural plant products: A review
Da, Z., Yang, K., Guo, H., Zeng, J., Wang, S., Xu, H., Ge, A., Zeng, L., Chen, S., & Ge, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114312 · Cited by 77
Histamine H3 receptor antagonists/inverse agonists on cognitive and motor processes: relevance to Alzheimer's disease, ADHD, schizophrenia, and drug abuse
Vohora, D., & Bhowmik, M. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00072 · Cited by 75
Spectral analysis of the rapid eye movement sleep electroencephalogram in right and left temporal regions: A biological marker of Alzheimer's disease
Petit, D., Montplaisir, J. Y., Lorrain, D., & Gauthier, S. G. (1992) · Annals of Neurology · doi:10.1002/ana.410320208 · Cited by 75
Basal Forebrain and Hippocampus as Predictors of Conversion to Alzheimer’s Disease in Patients with Mild Cognitive Impairment – A Multicenter DTI and Volumetry Study
Brueggen, K., Dyrba, M., Barkhof, F., Hausner, L., Filippi, M., Nestor, P. J., Hauenstein, K., Klöppel, S., Grothe, M. J., Kasper, E., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150063 · Cited by 73

Authors: Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R.
Affiliations: Johns Hopkins University (US)
Neuropathology Laboratory, Departments of Pathology and Neurology, Baltimore, Maryland 21205
Departments of Pharmacology and Experimental Therapy, Psychiatry, and Neuroscience, Baltimore, Maryland 21205
ORCID: DeLong, Mahlon R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1982-03-05
Volume: 215
Issue: 4537
Pages: 1237-1239
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.7058341
OpenAlex: W2093374391
Semantic Scholar: e0380e88fdffd5a546eb76a1d2eb7d05db143f94
Cited by: 3,627
References: 44
Citations by year: 2026: 52 · 2025: 42 · 2024: 53 · 2023: 67 · 2022: 62 · 2021: 91 · 2020: 95 · 2019: 66 · 2018: 63 · 2017: 66 · 2016: 82 · 2015: 65 · 2014: 73 · 2013: 63 · 2012: 56
FWCI: 110.00
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, senile dementia, nucleus basalis of Meynert, basal forebrain, cholinergic neurons, neuronal loss, cholinergic deficit, cerebral cortex, presynaptic markers, subcortical lesions
MeSH terms: Acetylcholine, Alzheimer Disease, Basal Ganglia, Dementia, Humans, Neural Pathways

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks