The dendritic hypothesis for Alzheimer's disease pathophysiology
Open accessAbstract
Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a "dendritic hypothesis" of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendritic integrity and disease progression. These dendritic mechanisms serve as a framework for therapeutic target identification and for efforts to develop disease-modifying therapeutics for Alzheimer's disease.
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Aβ, tau, and AD genetic risk factors affect dendritic integrity and disease progression.
“Aβ, tau, and AD genetic risk factors affect dendritic integrity and disease progression [14].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [14]
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- Authors
- Cochran, J. N., Hall, A. M., & Roberson, E. D.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Roberson, Erik D.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 103
- Pages
- 18-28
- ISSN
- 0361-9230 (ISSN-L)
- PMC
- PMC3989444
- OpenAlex
- W2046296412
- Cited by
- 114
- References
- 225
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 12 · 2014: 4
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (T32GM008111)
- National Institute of Neurological Disorders and Stroke (R01NS075487, T32NS061788)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, dendrites, amyloid-beta, tau protein, genetic risk factors, disease-modifying therapy, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Dendrites, Humans, Amyloid beta-Peptides, Neurites, Tauopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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