Cited by 114Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchDementia and Cognitive Impairment Research

The dendritic hypothesis for Alzheimer's disease pathophysiology

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Cochran, J. Nicholas, Hall, Alicia M., Roberson, Erik D.·2014·Brain Research Bulletin

Abstract

Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a "dendritic hypothesis" of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendritic integrity and disease progression. These dendritic mechanisms serve as a framework for therapeutic target identification and for efforts to develop disease-modifying therapeutics for Alzheimer's disease.

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Crossref · 10.1016/j.brainresbull.2013.12.004

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Research works printed but not linked: 5

  1. [31]Catala I Ferrer I Galofre E Fabregues I Hum Neurobiol 6 1988 255 259 3350705
  2. [66]el Hachimi KH Foncin JF C R Acad Sci III 311 1990 397 402 2125849
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Authors
Cochran, J. N., Hall, A. M., & Roberson, E. D.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Roberson, Erik D.
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
2014-04
Volume
103
Pages
18-28
ISSN
0361-9230 (ISSN-L)
OpenAlex
W2046296412
Cited by
114
References
225
Citations by year
2026: 5 · 2025: 3 · 2024: 13 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 12 · 2014: 4
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (T32GM008111)
  • National Institute of Neurological Disorders and Stroke (R01NS075487, T32NS061788)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, dendrites, amyloid-beta, tau protein, genetic risk factors, disease-modifying therapy, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Dendrites, Humans, Amyloid beta-Peptides, Neurites, Tauopathies

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