Excitatory and Inhibitory Effects of Serotonin on Sensorimotor Reactivity Measured with Acoustic Startle
Abstract
Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.
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Increases in serotonin levels reduce startle responses.
“Nevertheless, consistent with the notion that serotonin reduces neural gain, increases in serotonin levels reduce behavioural sensitivity to mechanosensory stimuli202 and reduce startle responses203.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [203]
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- Authors
- Davis, M., Strachan, D. I., & Kass, E.
- Affiliations
- Yale University (US)
- Venue
- Science
- Published
- 1980-07-25
- Volume
- 209
- Issue
- 4455
- Pages
- 521-523
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981997772
- Cited by
- 138
- References
- 23
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- serotonin, acoustic startle response, excitatory and inhibitory effects, lateral ventricle infusion, central nervous system localization, rats
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Kinetics, Male, Reflex, Acoustic, Serotonin, Reflex, Startle, Rats
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