Cited by 139Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Excitatory and Inhibitory Effects of Serotonin on Sensorimotor Reactivity Measured with Acoustic Startle

Davis, Michael, Strachan, David I., Kass, Elizabeth·1980·Science

Abstract

Serotonin infused into the lateral ventricle in rats produced a dose-dependent depression of the acoustic startle reflex. When infused onto the spinal cord, serotonin produced a dose-dependent increase in startle. Thus the same neurotransmitter can modulate the same behavior in opposite ways, depending on which part of the central nervous system is involved.

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Crossref · 10.1126/science.7394520

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23 of 23 references verified0 citation errors · 0 not checkable

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  • Increases in serotonin levels reduce startle responses.

    “Nevertheless, consistent with the notion that serotonin reduces neural gain, increases in serotonin levels reduce behavioural sensitivity to mechanosensory stimuli202 and reduce startle responses203.”

    From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [203]

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Authors
Davis, M., Strachan, D. I., & Kass, E.
Affiliations
Yale University (US)
Venue
Science
Published
1980-07-25
Volume
209
Issue
4455
Pages
521-523
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1981997772
Cited by
138
References
23
Citations by year
2025: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 1
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
serotonin, acoustic startle response, excitatory and inhibitory effects, lateral ventricle infusion, central nervous system localization, rats
MeSH terms
Animals, Dose-Response Relationship, Drug, Kinetics, Male, Reflex, Acoustic, Serotonin, Reflex, Startle, Rats

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