Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
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Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions.
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Recent studies on acute activation of DR serotonin neurons have reported divergent findings, including reinforcement, promotion of waiting for delayed reward, promotion of anxiety-like behaviors and suppression of locomotion, and suppression of locomotion without effects on reinforcement or anxiety-like behaviors.
“recent studies on the effects of acute activation of DR serotonin neurons have reported divergent findings, including reinforcement (Liu et al., 2014), promotion of waiting for delayed reward rather than reinforcement (Fonseca et al., 2015; Miyazaki et al., 2012), promotion of anxiety-like behaviors and suppression of locomotion (Teissier et al., 2015; Urban et al., 2016), and suppression of locom”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Correia et al., 2017
The DR serotonin system negatively regulates locomotion.
“The DR serotonin system has been consistently shown to negatively regulate locomotion (Correia et al., 2017; Teissier et al., 2015; Whitney et al., 2016).”
From Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems (2018) · cites this paper as Correia et al., 2017
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Aston-Jones, G., & Cohen, J. D. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135709 · Cited by 4,472 · see citing works
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
Structure and function of the brain serotonin system
Jacobs, B. L., & Azmitia, E. C. (1992) · Physiological Reviews · doi:10.1152/physrev.1992.72.1.165 · Cited by 2,574 · see citing works
Daw, N. D., Niv, Y., & Dayan, P. (2005) · Nature Neuroscience · doi:10.1038/nn1560 · Cited by 2,533 · see citing works
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881 · see citing works
Uncertainty, Neuromodulation, and Attention
Yu, A. J., & Dayan, P. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.026 · Cited by 1,774 · see citing works
Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
Seibenhener, M. L., & Wooten, M. C. (2015) · Journal of Visualized Experiments · doi:10.3791/52434 · Cited by 1,467 · see citing works
Hall, C. S. (1934) · Journal of comparative psychology · doi:10.1037/h0071444 · Cited by 1,365 · see citing works
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
Cohen, J. Y., Haesler, S., Vong, L., Lowell, B. B., & Uchida, N. (2012) · Nature · doi:10.1038/nature10754 · Cited by 1,318 · see citing works
Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning
Tsai, H.-C., Zhang, F., Adamantidis, A., Stuber, G. D., Bonci, A., de Lecea, L., & Deisseroth, K. (2009) · Science · doi:10.1126/science.1168878 · Cited by 1,266 · see citing works
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226 · see citing works
Tonic dopamine: Opportunity costs and the control of response vigor
Niv, Y., Daw, N. D., Joel, D., & Dayan, P. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0502-4 · Cited by 1,133 · see citing works
The role of the dorsomedial striatum in instrumental conditioning
Yin, H. H., Ostlund, S. B., Knowlton, B. J., & Balleine, B. W. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04218.x · Cited by 1,099 · see citing works
Crouching as an index of fear.
Blanchard, R. J., & Blanchard, D. C. (1969) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0026779 · Cited by 1,077 · see citing works
Reconciling the role of central serotonin neurons in human and animal behavior
Soubrié, P. (1986) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00022871 · Cited by 993 · see citing works
Gong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977 · see citing works
Amat, J., Baratta, M. V., Paul, E., Bland, S. T., Watkins, L. R., & Maier, S. F. (2005) · Nature Neuroscience · doi:10.1038/nn1399 · Cited by 931 · see citing works
The antidepressant fluoxetine restores plasticity in the adult visual cortex
Vetencourt, J. F. M., Sale, A., Viegi, A., Baroncelli, L., De Pasquale, R., F. O'Leary, O., Castrén, E., & Maffei, L. (2008) · Science · doi:10.1126/science.1150516 · Cited by 890 · see citing works
Opponent interactions between serotonin and dopamine
Daw, N. D., Kakade, S., & Dayan, P. (2002) · Neural Networks · doi:10.1016/s0893-6080(02)00052-7 · Cited by 844 · see citing works
Methods of Behavior Analysis in Neuroscience
(2008) · CRC Press eBooks · doi:10.1201/9780367802622 · Cited by 777 · see citing works
Choleris, E. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00011-2 · Cited by 761 · see citing works
Effects of SSRIs on Sexual Function
Rosen, R. C., Lane, R. M., & Menza, M. A. (1999) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199902000-00013 · Cited by 649 · see citing works
A prefrontal cortex–brainstem neuronal projection that controls response to behavioural challenge
Warden, M. R., Selimbeyoglu, A., Mirzabekov, J. J., Lo, M., Thompson, K. R., Kim, S.-Y., Adhikari, A., Tye, K. M., Frank, L. M., & Deisseroth, K. (2012) · Nature · doi:10.1038/nature11617 · Cited by 645 · see citing works
Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review
Vaswani, M., Linda, F. K., & Ramesh, S. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00338-x · Cited by 612 · see citing works
Bonsai: an event-based framework for processing and controlling data streams
Lopes, G., Bonacchi, N., Frazão, J., Neto, J. P., Atallah, B. V., Soares, S., MOREIRA, L. M. A. G., Matias, S., Itskov, P. M., Correia, P. A., et al. (2015) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2015.00007 · Cited by 602 · see citing works
Self-citationDopamine, serotonin and impulsivity
Dalley, J. W., & Roiser, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.065 · Cited by 501 · see citing works
Motor Coordination and Balance in Rodents
Carter, R. J., Morton, J. P., & Dunnett, S. B. (2001) · Current Protocols in Neuroscience · doi:10.1002/0471142301.ns0812s15 · Cited by 479 · see citing works
Dorsal raphe neurons signal reward through 5-HT and glutamate
Liu, Z., Zhou, J., Li, Y., Hu, F., Lu, Y., Ma, M., Feng, Q., Zhang, J.-E., Wang, D., Zeng, J., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.010 · Cited by 469 · see citing works
Serotonin and dopamine: unifying affective, activational, and decision functions.
Cools, R., Nakamura, K., & Daw, N. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.121 · Cited by 464 · see citing works
Opponency revisited: competition and cooperation between dopamine and serotonin
Boureau, Y.-L., & Dayan, P. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.151 · Cited by 456 · see citing works
Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala
Marcinkiewcz, C. A., Mazzone, C. M., D’Agostino, G., Halladay, L. R., Hardaway, J. A., DiBerto, J. F., Navarro, M., Burnham, N., Cristiano, C., Dorrier, C. E., et al. (2016) · Nature · doi:10.1038/nature19318 · Cited by 456 · cited 1× · see citing works
“Marcinkiewcz et al. (2016) showed that optogenetic activation of BNST-projecting DRN 5-HT neurons increase anxiety-like behaviors without affecting locomotion.”
BackgroundCerebral Activity and Behavior: Control by Central Cholinergic and Serotonergic Systems
Vanderwolf, C. H. (1988) · International review of neurobiology · doi:10.1016/s0074-7742(08)60050-1 · Cited by 455 · see citing works
Harrison, A. A., Everitt, B. J., & Robbins, T. W. (1997) · Psychopharmacology · doi:10.1007/s002130050410 · Cited by 452 · see citing works
5-HT and motor control: a hypothesis
Jacobs, B. L., & Fornal, C. A. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90090-9 · Cited by 452 · see citing works
Serotonin research: contributions to understanding psychoses
GEYER, M., & VOLLENWEIDER, F. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.06.006 · Cited by 427 · see citing works
Serotonergic neurons signal reward and punishment on multiple timescales
Cohen, J. Y., Amoroso, M. W., & Uchida, N. (2015) · eLife · doi:10.7554/elife.06346 · Cited by 388 · see citing works
The current state of the neurogenic theory of depression and anxiety
Miller, B. R., & Hen, R. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.08.012 · Cited by 386 · see citing works
Serotonin in Affective Control
Dayan, P., & Huys, Q. J. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135607 · Cited by 381 · see citing works
Winstanley, C. A., Dalley, J. W., Theobald, D. E., & Robbins, T. W. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300434 · Cited by 371 · see citing works
Impulsivity, aggression, and serotonin: a molecular psychobiological perspective
Lesch, K., & Merschdorf, U. (2000) · Behavioral Sciences & the Law · doi:10.1002/1099-0798(200010)18:5 · Cited by 364 · see citing works
Acute off-target effects of neural circuit manipulations
Otchy, T. M., Wolff, S. B. E., Rhee, J. Y., Pehlevan, C., Kawai, R., Kempf, A., Gobes, S. M. H., & Ölveczky, B. P. (2015) · Nature · doi:10.1038/nature16442 · Cited by 352 · see citing works
Methods of Behavior Analysis in Neuroscience
(2000) · CRC Press eBooks · doi:10.1201/9781420041811 · Cited by 345 · see citing works
The Yin and Yang of dopamine release: a new perspective
GOTO, Y., OTANI, S., & GRACE, A. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.007 · Cited by 342 · see citing works
Winstanley, C. A., Theobald, D. E. H., Dalley, J. W., Glennon, J. C., & Robbins, T. W. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1884-9 · Cited by 323 · see citing works
Phasic norepinephrine: A neural interrupt signal for unexpected events
Dayan, P., & Yu, A. J. (2006) · Network Computation in Neural Systems · doi:10.1080/09548980601004024 · Cited by 302 · see citing works
Optogenetic Activation of Dorsal Raphe Serotonin Neurons Enhances Patience for Future Rewards
Miyazaki, K. W., Miyazaki, K., Tanaka, K. F., Yamanaka, A., Takahashi, A., Tabuchi, S., & Doya, K. (2014) · Current Biology · doi:10.1016/j.cub.2014.07.041 · Cited by 278 · see citing works
The timing of antidepressant effects: a comparison of diverse pharmacological and somatic treatments
Machado-Vieira, R., Baumann, J., Wheeler-Castillo, C., Latov, D., Henter, I. D., Salvadore, G., & Zarate, C. A. (2010) · Pharmaceuticals · doi:10.3390/ph3010019 · Cited by 263 · see citing works
Serotonin, inhibition, and negative mood
Dayan, P., & Huys, Q. J. M. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0040004 · Cited by 263 · see citing works
Wigger, A., Sánchez, M. M., Mathys, K. C., Ebner, K., Frank, E., Liu, D., Kresse, A. E., Neumann, I. D., Holsboer, F., Plotsky, P. M., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300290 · Cited by 263 · see citing works
Activation of Dorsal Raphe Serotonin Neurons Underlies Waiting for Delayed Rewards
Miyazaki, K., Miyazaki, K. W., & Doya, K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3714-10.2011 · Cited by 257 · see citing works
Vanderwolf, C. H., & Baker, G. B. (1986) · Brain Research · doi:10.1016/0006-8993(86)90428-2 · Cited by 256 · see citing works
Toward a unified theory of serotonin dysregulation in eating and related disorders
Brewerton, T. D. (1995) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00001-5 · Cited by 245 · see citing works
Redefining the serotonergic system by genetic lineage
Jensen, P., Farago, A. F., Awatramani, R. B., Scott, M. M., Deneris, E. S., & Dymecki, S. M. (2008) · Nature Neuroscience · doi:10.1038/nn2050 · Cited by 244 · see citing works
Reward-Dependent Modulation of Neuronal Activity in the Primate Dorsal Raphe Nucleus
Nakamura, K., Matsumoto, M., & Hikosaka, O. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0021-08.2008 · Cited by 243 · see citing works
Activity patterns of serotonin neurons underlying cognitive flexibility
Matias, S., Lottem, E., Dugué, G. P., & Mainen, Z. F. (2017) · eLife · doi:10.7554/elife.20552 · Cited by 239 · see citing works
Self-citationA genetic approach to access serotonin neurons for in vivo and in vitro studies
Scott, M. M., Wylie, C. J., Lerch, J. K., Murphy, R., Lobur, K. J., Herlitze, S., Jiang, W., Conlon, R. A., Strowbridge, B. W., & Deneris, E. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504510102 · Cited by 233 · see citing works
Distinct Eligibility Traces for LTP and LTD in Cortical Synapses
He, K., Huertas, M. A., Hong, S. Z., Tie, X., Hell, J. W., Shouval, H. Z., & Kirkwood, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.037 · Cited by 220 · see citing works
Activation of Dorsal Raphe Serotonergic Neurons Promotes Waiting but Is Not Reinforcing
Fonseca, M. S., Murakami, M., & Mainen, Z. F. (2015) · Current Biology · doi:10.1016/j.cub.2014.12.002 · Cited by 210 · see citing works
Self-citationMcDevitt, R. A., Tiran-Cappello, A., Shen, H., Balderas, I., Britt, J. P., Marino, R. A. M., Chung, S. L., Richie, C. T., Harvey, B. K., & Bonci, A. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.08.037 · Cited by 203 · see citing works
Activity of Raphé serotonergic neurons controls emotional behaviors
Teissier, A., Chemiakine, A., Inbar, B., Bagchi, S., Ray, R. S., Palmiter, R. D., Dymecki, S. M., Moore, H., & Ansorge, M. S. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.061 · Cited by 197 · see citing works
A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons
Qi, J., Zhang, S. S., Wang, H., Wang, H., Buendia, J. D. J. A., Hoffman, A. F., Lupica, C. R., Seal, R. P., & Morales, M. (2014) · Nature Communications · doi:10.1038/ncomms6390 · Cited by 195 · see citing works
Machado, A. S., Darmohray, D. M., Fayad, J., Marques, H. G., & Carey, M. R. (2015) · eLife · doi:10.7554/elife.07892 · Cited by 183 · see citing works
Self-citationRanade, S., & Mainen, Z. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.00507.2009 · Cited by 174 · see citing works
Self-citationInvolvement of Serotonin in Developmental Plasticity of Kitten Visual Cortex
Gu, Q., & Singer, W. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01104.x · Cited by 173 · see citing works
Dunlop (2016) · doi:10.1038/npp.2015.293 · Cited by 166 · see citing works
The role of serotonin in the regulation of patience and impulsivity
Miyazaki, K., Miyazaki, K. W., & Doya, K. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8232-6 · Cited by 162 · see citing works
Branchi, I. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.08.011 · Cited by 156 · see citing works
Eagle, D. M., Lehmann, O., Theobald, D. E. H., Peña, Y., Zakaria, R., Ghosh, R., Dalley, J. W., & Robbins, T. W. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.202 · Cited by 155 · see citing works
Harrison, A. A., Everitt, B. J., & Robbins, T. W. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00117-x · Cited by 152 · see citing works
Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits
Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 145 · see citing works
Apathy in Neuropsychiatric Disease: Diagnosis, Pathophysiology, and Treatment
Chase, T. N. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9196-9 · Cited by 141 · see citing works
Vetencourt, J. F. M., Tiraboschi, E., Spolidoro, M., Castrén, E., & Maffei, L. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07488.x · Cited by 138 · see citing works
Davis, M., Strachan, D. I., & Kass, E. (1980) · Science · doi:10.1126/science.7394520 · Cited by 138 · see citing works
Optogenetic activation of serotonergic neurons enhances anxiety-like behaviour in mice
Ohmura, Y., Tanaka, K. F., Tsunematsu, T., Yamanaka, A., & Yoshioka, M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000637 · Cited by 122 · see citing works
Habituation and sensitization of the rat startle response: Effects of raphe lesions☆
Davis, M., & Sheard, M. H. (1974) · Physiology & Behavior · doi:10.1016/0031-9384(74)90120-6 · Cited by 120 · see citing works
A specific role for serotonin in overcoming effort cost
Meyniel, F., Goodwin, G. M., Deakin, J. F. W., Klinge, C., MacFadyen, C., Milligan, H., Mullings, E. L., Pessiglione, M., & Raphaël Gaillard, B. (2016) · eLife · doi:10.7554/elife.17282 · Cited by 120 · see citing works
The Efficacy of Selective Serotonin Reuptake Inhibitors for the Management of Chronic Pain
Jung, A. C., Staiger, T. O., & Sullivan, M. D. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.00064.x · Cited by 119 · see citing works
Reward processing by the dorsal raphe nucleus: 5-HT and beyondPreprint
Luo, M., Zhou, J., & Liu, Z. (2015) · Learning & Memory · doi:10.1101/lm.037317.114 · Cited by 117 · see citing works
Rothermel, M., Brunert, D., Zabawa, C., Díaz-Quesada, M., & Wachowiak, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1618-13.2013 · Cited by 116 · see citing works
The Efficacy of Selective Serotonin Reuptake Inhibitors for the Management of Chronic Pain
Jung, A. C., Staiger, T. O., & Sullivan, M. D. (1997) · Journal of General Internal Medicine · doi:10.1007/s11606-006-5088-3 · Cited by 96 · see citing works
Markou, A., Salamone, J. D., Bussey, T. J., Mar, A. C., Brunner, D., Gilmour, G., & Balsam, P. D. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.007 · Cited by 93 · see citing works
Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study
Kojić, L., Gu, Q., Douglas, R. M., & Cynader, M. S. (1997) · Developmental Brain Research · doi:10.1016/s0165-3806(97)00083-7 · Cited by 82 · see citing works
Vanderwolf, C. H. (1989) · Brain Research · doi:10.1016/0006-8993(89)91356-5 · Cited by 67 · see citing works
Medical data transformation using rewriting
Ashish, N., & Toga, A. W. (2015) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2015.00001 · Cited by 64 · see citing works
Activation of the central serotonergic system in response to delayed but not omitted rewards
Miyazaki, K. W., Miyazaki, K., & Doya, K. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07480.x · Cited by 59 · see citing works
Dugué, G. P., Lörincz, M. L., Lottem, E., Audero, E., Matias, S., Correia, P. A., Léna, C., & Mainen, Z. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105941 · Cited by 54 · see citing works
Self-citationGately, P. F., Poon, S. L., Segal, D. S., & Geyer, M. A. (1985) · Psychopharmacology · doi:10.1007/bf00432502 · Cited by 52 · see citing works
Maswood, N., Caldarola-Pastuszka, M., & Uphouse, L. L. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00554-x · Cited by 39 · see citing works
Bailey, M. R., Williamson, C. M., Mezias, C., Winiger, V., Silver, R., Balsam, P. D., & Simpson, E. H. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4135-3 · Cited by 39 · see citing works
Correia, P. A., Matias, S., & Mainen, Z. F. (2017) · BIO-PROTOCOL · doi:10.21769/bioprotoc.2549 · Cited by 16 · see citing works
Self-citationFiring patterns of serotonin neurons underlying cognitive flexibilityPreprint
Matias, S., Lottem, E., Dugué, G. P., & Mainen, Z. F. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/059758 · Cited by 4 · see citing works
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Embracing diversity in the 5-HT neuronal system
Okaty, B. W., Commons, K. G., & Dymecki, S. M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0151-3 · Cited by 319 · see citing works
5-HT release in nucleus accumbens rescues social deficits in mouse autism model
Walsh, J. J., Christoffel, D. J., Heifets, B. D., Ben-Dor, G. A., Selimbeyoglu, A., Hung, L. W., Deisseroth, K., & Malenka, R. C. (2018) · Nature · doi:10.1038/s41586-018-0416-4 · Cited by 256 · see citing works
Iigaya, K., Fonseca, M. S., Murakami, M., Mainen, Z. F., & Dayan, P. (2018) · Nature Communications · doi:10.1038/s41467-018-04840-2 · Cited by 120 · see citing works
Self-citationDorsal tegmental dopamine neurons gate associative learning of fear
Groessl, F., Munsch, T., Meis, S., Griessner, J., Kaczanowska, J., Pliota, P., Kargl, D., Badurek, S., Kraitsy, K., Rassoulpour, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0174-5 · Cited by 118 · see citing works
Serotonergic modulation of walking in Drosophila
Howard, C. E., Chen, C.-L., Tabachnik, T., Hormigo, R., Ramdya, P., & Mann, R. S. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.042 · Cited by 59 · see citing works
Serotonin Decreases the Gain of Visual Responses in Awake Macaque V1
Seillier, L., Lorenz, C., Kawaguchi, K., Ott, T., Nieder, A., Pourriahi, P., & Nienborg, H. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.1339-17.2017 · Cited by 57 · see citing works
Sargin, D., Jeoung, H.-S., Goodfellow, N. M., & Lambe, E. K. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00073 · Cited by 54 · see citing works
Serotonin modulates asymmetric learning from reward and punishment in healthy human volunteers
Michely, J., Eldar, E., Erdman, A., Martin, I. M., & Dolan, R. J. (2022) · Communications Biology · doi:10.1038/s42003-022-03690-5 · Cited by 43 · see citing works
Ryczko, D. (2024) · The Neuroscientist · doi:10.1177/10738584221139136 · Cited by 31 · see citing works
- Authors
- Correia, P. A., Lottem, E., Banerjee, D., Machado, A. S., Carey, M. R., & Mainen, Z. F.
- Affiliations
- Champalimaud Neuroscience Program, Champalimaud Centre for the Unknown, Lisbon, Portugal
- Champalimaud Foundation (PT)
- Corresponding author
- Mainen, Zachary F
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2017-02-14
- Volume
- 6
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5308893
- OpenAlex
- W2587959010
- Cited by
- 138
- References
- 92
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 13 · 2023: 6 · 2022: 11 · 2021: 15 · 2020: 22 · 2019: 18 · 2018: 13 · 2017: 11
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Fundação para a Ciência e Tecnologia (SFRH / BD / 33277 / 2007, SFRH/BD/51210/2010)
- Human Frontier Science Program (LT000881/2011L)
- Howard Hughes Medical Institute (International Early Career Scientist)
- European Research Council (Starting Investigator Grant 640093, Advanced Investigator Grant 250334, Advanced Investigator Grant 671251)
- Champalimaud Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- serotonin, dorsal raphe nucleus, locomotion, optogenetic stimulation, transient inhibition, long-term facilitation, motivation, spontaneous behavior, place preference, aversion
- MeSH terms
- Animals, Anxiety, Locomotion, Motivation, Neural Inhibition, Neurons, Serotonin, Serotonin Receptor Agonists, Mice, Optogenetics, Dorsal Raphe Nucleus
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