Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, Nam W., Piatyszek, Mieczyslaw A., Prowse, Karen R., Harley, Calvin B., West, Michael D., Ho, Peter L. C., Coviello, Gina M., Wright, Woodring E., Weinrich, Scott L., Shay, Jerry W.·1994·Science
Cited by (1,043)
Items 401–500 of 1,043
- Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1.Çagatay Güneş, Serge Lichtsteiner, Alain P. Vasserot, Christoph Englert · 2000 · PubMed
- Molecular biology of colorectal cancerRobert Gryfe, Bharati V. Bapat, Steve Gallinger, Carol Jane Swallow, Mark S. Redston, Jean Couture · 1997 · Current Problems in Cancer
- Telomerase activity in human brain tumoursLauren A. Langford, Mieczyslaw A. Piatyszek, Jerry W. Shay, S. Clifford Schold · 1995 · The Lancet
- Porphyrin Binding to Quadruplexed T4G4Narayanan V. Anantha, Mahrukh Azam, Richard D. Sheardy · 1998 · Biochemistry
- Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1–Mediated Activation of Two GC-Rich Promoter ElementsArvind Dasari, Janine N. Bartholomew, Daniela Volonté, Ferruccio Galbiati · 2006 · Cancer Research
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- Telomere Length Assessment in Human Archival TissuesMeeker, Alan K., Gage, Wesley R., Hicks, Jessica L., Simon, Inpakala, Coffman, Jonathan R., Platz, Elizabeth A., March, Gerrun E., De Marzo, Angelo M. · 2002 · The American Journal of Pathology
- Hypoxia-Inducible Factor 1 Mediates Upregulation of Telomerase (hTERT)Hirotaka Nishi, Toshihide Nakada, Satoru Kyo, Masaki Inoue, Jerry W. Shay, Keiichi Isaka · 2004 · Molecular and Cellular Biology
- Telomerase Is Controlled by Protein Kinase Cα in Human Breast Cancer CellsHe Li, Linlin Zhao, Zhiyong Yang, John W. Funder, Junping Liu · 1998 · Journal of Biological Chemistry
- Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanismsParul Gupta, Stephen E. Wright, Sung‐Hoon Kim, Sanjay Srivastava · 2014 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Natural and synthetic G-quadruplex interactive berberine derivativesMarco Franceschin, Luigi Rossetti, A D'Ambrosio, Stefano Schirripa, Armandodoriano Bianco, Giancarlo Ortaggi, Maria Savino, Christoph M. Schultes, Stephen Neidle · 2006 · Bioorganic & Medicinal Chemistry Letters
- Human POT1 Facilitates Telomere Elongation by TelomeraseLorel M. Colgin, Katherine Baran, Peter Baumann, Thomas R. Cech, Roger R. Reddel · 2003 · Current Biology
- The role of senescence and immortalization in carcinogenesisRoger R. Reddel · 2000 · Carcinogenesis
- National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Liver, Bladder, Cervical, and Gastric CancersCatharine M. Sturgeon, Michael Joe Duffy, Barry R Hofmann, R. Lamerz, Herbert A. Fritsche, Katja N. Gaarenstroom, Johannes M.G. Bonfrèr, Thorsten Ecke, Herbert Barton Grossman, Peter Clive Hayes et al. · 2010 · Clinical Chemistry
- Hallmarks of telomeres in ageing researchJW Shay, Woodring Erik Wright · 2007 · The Journal of Pathology
- Molecular biology of prostatic intraepithelial neoplasiaDavid G. Bostwick, Anna Pacelli, Antonio Lopez-beltran B · 1996 · The Prostate
- Expression of Caveolin-1 Induces Premature Cellular Senescence in Primary Cultures of Murine FibroblastsDaniela Volonté, Kun Zhang, Michael P. Lisanti, Ferruccio Galbiati · 2002 · Molecular Biology of the Cell
- Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrityEmilio Cusanelli, Pascal Chartrand · 2015 · Frontiers in Genetics
- Updates on the biology and management of dyskeratosis congenita and related telomere biology disordersBari J. Ballew, Sharon A. Savage · 2013 · Expert Review of Hematology
- Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal lociZhang, Hong, Pan, Kuang-Hung, Cohen, Stanley N. · 2003 · Proceedings of the National Academy of Sciences
- An evolutionary review of human telomere biology: The thrifty telomere hypothesis and notes on potential adaptive paternal effectsDan T. A. Eisenberg · 2010 · American Journal of Human Biology
- Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and CancerWanil Kim, Andrew T. Ludlow, Jaewon Min, Jérôme D. Robin, Guido Stadler, Ilgen Mender, Tsung‐Po Lai, Ning Zhang, Woodring Erik Wright, Jerry W. Shay · 2016 · PLoS Biology
- FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loopsBruno Dias Rodrigues Silva, Richard Pentz, Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin · 2019 · Nature Communications
- Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone MarrowYui, Jane, Chiu, Choy-Pik, Lansdorp, Peter M. · 1998 · Blood
- Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen SpeciesSanthi Achuthan, Thankayyan Retnabai Santhoshkumar, Jem Prabhakar, S. Asha Nair, M. Radhakrishna Pillai · 2011 · Journal of Biological Chemistry
- The zebrafish as a vertebrate model of functional aging and very gradual senescenceShuji Kishi, Junzo Uchiyama, Anne M Baughman, Tadateru Goto, Mao C. Lin, Stephanie B Tsai · 2003 · Experimental Gerontology
- Selection and Extended Growth of Murine Epidermal Stem Cells in CultureJackie R. Bickenbach, Emily Chism · 1998 · Experimental Cell Research
- A Chiral Wedge Molecule Inhibits Telomerase ActivityKen‐ichi Shinohara, Yuta Sannohe, Shuji Kaieda, Kenichi Tanaka, Hideji Osuga, Hidetoshi Tahara, Yan Xu, Takashi Kawase, Toshikazu Bando, Hiroshi Sugiyama · 2010 · Journal of the American Chemical Society
- A Platinum Supramolecular Square as an Effective G-Quadruplex Binder and Telomerase InhibitorRoxanne E. Kieltyka, Pablo Englebienne, Johans J. Fakhoury, Chantal Autexier, Nicolas Moitessier, Hanadi F. Sleiman · 2008 · Journal of the American Chemical Society
- G-quadruplexes as therapeutic targetsStephen Neidle, Martin A. Read · 2000 · Biopolymers
- From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell agingHomayoun Vaziri, Samuel Benchimol · 1996 · Experimental Gerontology
- Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo.Imad Naasani, Fujiko Oh-hashi, Tomoko Oh‐hara, Wan Yong Feng, Jeffrey S. Johnston, Kenneth Chan, Takashi Tsuruo · 2003 · PubMed
- Bladder cancer in the elderlyShahrokh François Shariat, Matthew I. Milowsky, Michael J. Droller · 2009 · Urologic Oncology Seminars and Original Investigations
- Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT geneS. Renaud, Dmitri I. Loukinov, Ziedulla Abdullaev, Isabelle Guilleret, Fred T. Bosman, Victor V. Lobanenkov, Jean Benhattar · 2007 · Nucleic Acids Research
- Cell Cycle-dependent Recruitment of Telomerase RNA and Cajal Bodies to Human TelomeresBeáta E. Jády, Patricia Richard, Édouard Bertrand, Tamás Kiss · 2005 · Molecular Biology of the Cell
- Curcumin―The Paradigm of a Multi-Target Natural Compound with Applications in Cancer Prevention and TreatmentMarie-Hélène Teiten, Serge Eifes, Mario A. Dicato, Marc F. Diederich · 2010 · Toxins
- Role of Telomerase in Normal and Cancer CellsMatthew M. Meyerson · 2000 · Journal of Clinical Oncology
- Sphingosine‐1‐phosphate induces proliferation and morphological changes of neural progenitor cellsJun Harada, Melissa Foley, Michael A. Moskowitz, Christian Waeber · 2004 · Journal of Neurochemistry
- SYBR Green real-time telomeric repeat amplification protocol for the rapid quantification of telomerase activityHenning Wege · 2002 · Nucleic Acids Research
- Tales of tails: regulation of telomere length and telomerase activity during lymphocyte development, differentiation, activation, and agingNan‐ping Weng, Larry D. Palmer, Bruce L. Levine, Henry Clifford Lane, Carl H. June, Richard J. Hodes · 1997 · Immunological Reviews
- Pluripotent Stem Cells Derived From Adult Human TestesNady Golestaneh, Maria Kokkinaki, Disha Pant, Jiji Jiang, David DeStefano, Carlos Fernandez-Bueno, Janice D. Rone, Bassem R. Haddad, G. Ian Gallicano, Martin Dym · 2009 · Stem Cells and Development
- Clinical utility of telomerase in cancerEiso Hiyama, Keiko Hiyama · 2002 · Oncogene
- TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeresWilliam Chang, Jasmin N. Dynek, Susan Harless Smith · 2003 · Genes & Development
- Lineage-Specific Telomere Shortening and Unaltered Capacity for Telomerase Expression in Human T and B Lymphocytes with AgeSon, Ni Huiping, Murray, Shannon, Yanovski, Jack, Hodes, Richard J, Weng, Nan-ping · 2000 · The Journal of Immunology
- Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNAMeghan T. Mitchell, Andrew Gillis, Mizuko Futahashi, Haruhiko Fujiwara, Emmanuel Skordalakes · 2010 · Nature Structural & Molecular Biology
- Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenitaJudy M.Y. Wong, Kathleen Collins · 2006 · Genes & Development
- Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.Hideki Harada, Hiroshi Nakagawa, Kenji Oyama, Munenori Takaoka, Claudia D. Andl, Birgit Jacobmeier, Alexander von Werder, Gregory H. Enders, Oliver G. Opitz, Anil K. Rustgi · 2003 · PubMed
- Structure-specific recognition of quadruplex DNA by organic cations: Influence of shape, substituents and chargeElizabeth W. White, Farial A. Tanious, Mohamed A. Ismail, Anthony P. Reszka, Stephen Neidle, David W. Boykin, W. David Wilson · 2006 · Biophysical Chemistry
- Protein Phosphatase 2A Inhibits Nuclear Telomerase Activity in Human Breast Cancer CellsHe Li, Linlin Zhao, John W. Funder, Junping Liu · 1997 · Journal of Biological Chemistry
- Arrangements of human telomere DNA quadruplex in physiologically relevant K + solutionsDaniel Renčiuk, Iva Kejnovská, Petra Školáková, Klára Bednářová, Jitka Motlová, Michaela Vorlíčková · 2009 · Nucleic Acids Research
- TERT promoter mutations in telomere biologyBarbara Heidenreich, Rajiv Kumar · 2016 · Mutation Research/Reviews in Mutation Research
- Telomerase regulation during entry into the cell cycle in normal human T cells.Karen J. Buchkovich, Carol W. Greider · 1996 · Molecular Biology of the Cell
- Exploration of liver cancer genomesTatsuhiro Shibata, Hiroyuki Aburatani · 2014 · Nature Reviews Gastroenterology & Hepatology
- The Bloom syndrome helicase BLM interacts with TRF2 in ALT cells and promotes telomeric DNA synthesisDimitrios J. Stavropoulos · 2002 · Human Molecular Genetics
- High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic StageAlbanell, J., Engelhardt, M., Han, W., Moore, M. A. S., Lonardo, F., Rusch, V., Langenfeld, J., Klimstra, D., Venkatraman, E., Dmitrovsky, E. · 1997 · JNCI Journal of the National Cancer Institute
- Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by TelomeraseFarwell, D. Gregory, Shera, Katherine A., Koop, Jennifer I., Bonnet, George A., Matthews, Connie P., Reuther, Gary W., Coltrera, Marc D., McDougall, James K., Klingelhutz, Aloysius J. · 2000 · The American Journal of Pathology
- Serum-free derivation of human embryonic stem cell lines on human placental fibroblast feedersOlga Genbačev, Ana Krtolica, Tamara Zdravkovic, Elisa Brunette, Sandra Powell, Aneel Nath, Eduardo Caceres, Michael McMaster, Susan McDonagh, Yan Li et al. · 2005 · Fertility and Sterility
- In vivo telomere dynamics of human hematopoietic stem cellsRosario Notaro, Amelia Cimmino, Diane Tabarini, Bruno Rotoli, Lucio Luzzatto · 1997 · Proceedings of the National Academy of Sciences
- Rapid Telomere Shortening in ChildrenSteven L. Zeichner, Paul E Palumbo, Yanru Feng, Xiaodong Xiao, Dennis Gee, John W. Sleasman, Maureen M. Goodenow, Robert J. Biggar, Dimiter Stanchev Dimitrov · 1999 · Blood
- Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cellsXiaoming Yi · 2001 · Nucleic Acids Research
- Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication ProcessesJaewon Min, Woodring Erik Wright, Jerry W. Shay · 2017 · Molecular and Cellular Biology
- Telomerase is not an oncogeneCalvin B. Harley · 2002 · Oncogene
- Differential effects of endurance, interval, and resistance training on telomerase activity and telomere length in a randomized, controlled studyWerner, Christian M, Hecksteden, Anne, Morsch, Arne, Zundler, Joachim, Wegmann, Melissa, Kratzsch, Jürgen, Thiery, Joachim, Hohl, Mathias, Bittenbring, Jörg Thomas, Neumann, Frank et al. · 2019 · European Heart Journal
- Activated p53 suppresses the histone methyltransferase EZH2 geneXiaohu Tang, Michael Milyavsky, Igor Shats, Neta Erez, Naomi Goldfinger, Varda Rotter · 2004 · Oncogene
- Anti-Cancer Activity of Derivatives of 1,3,4-OxadiazoleTeresa Glomb, Karolina Szymankiewicz, Piotr Świątek · 2018 · Molecules
- Telomeres and mechanisms of Robertsonian fusionPredrag Slijepčević · 1998 · Chromosoma
- Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem CellsRichard Allsopp, Samuel Henry Cheshier, Irving L. Weissman · 2001 · The Journal of Experimental Medicine
- Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNAShang Li, Jonathan E. Rosenberg, Annemarie A. Donjacour, Inna L. Botchkina, Yun Kit Hom, Gerald R. Cunha, Elizabeth Helen Blackburn · 2004 · Cancer Research
- Telomerase RNA Accumulates in Cajal Bodies in Human Cancer CellsYusheng Zhu, Rebecca L. Tomlinson, Andrew A. Lukowiak, Rebecca M. Terns, Michael P. Terns · 2003 · Molecular Biology of the Cell
- The fetal programming of telomere biology hypothesis: an updateSonja Entringer, Karin de Punder, Claudia Buß, Pathik D. Wadhwa · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
- Vascular endothelial growth factor expression in primary esophageal squamous cell carcinomaKimitoshi Inoue, Yuichi Ozeki, Toshiyuki Suganuma, Yoshiaki Sugiura, Susumu Tanaka · 1997 · Cancer
- STRUCTURE, FUNCTION, AND REPLICATION OF SACCHAROMYCES CEREVISIAE TELOMERESVirginia A. Zakian · 1996 · Annual Review of Genetics
- Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanismPornima Phatak, J.C. Cookson, Fangping Dai, Victoria Smith, Ronald B. Gartenhaus, Malcolm F. G. Stevens, A M Burger · 2007 · British Journal of Cancer
- The Telomere Lengthening Mechanism in Telomerase-Negative Immortal Human Cells Does Not Involve the Telomerase RNA SubunitTracy M. Bryan, Lidija Marusic, Silvia Bacchetti, Masayoshi Namba, Roger R. Reddel · 1997 · Human Molecular Genetics
- Role of nuclear glutathione as a key regulator of cell proliferationFederico Vicente Pallardó, Jelena Marković, Jose Luis García‐Giménez, José Viña · 2009 · Molecular Aspects of Medicine
- Telomerase as tumor markerEiso Hiyama, Keiko Hiyama · 2003 · Cancer Letters
- The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageingAndrew J. Young · 2018 · Philosophical Transactions of the Royal Society B Biological Sciences
- Telomere Shortening in Kidneys with AgeMELK, ANETTE, RAMASSAR, VIDO, HELMS, LISA M. H., MOORE, RON, RAYNER, DAVID, SOLEZ, KIM, HALLORAN, PHILIP F. · 2000 · Journal of the American Society of Nephrology
- Alteration of Liver Cell Function and Proliferation: Differentiation Between Adaptation and ToxicityGary M. Williams, Michael J. Iatropoulos · 2002 · Toxicologic Pathology
- Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric RepeatEvripidis Gavathiotis, Robert A. Heald, Malcolm F. G. Stevens, Mark S. Searle · 2003 · Journal of Molecular Biology
- Nonhuman primate parthenogenetic stem cellsKent E. Vrana, Jason Hipp, Ashley Goss, Brian A. McCool, David R. Riddle, Stephen J. Walker, Peter J. Wettstein, Lorenz Studer, Viviane S. Tabar, Kerrianne Cunniff et al. · 2003 · Proceedings of the National Academy of Sciences
- Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer.Monika Martha Engelhardt, Pamela R. Drullinsky, J G Guillem, Malcolm A.S. Moore · 1997 · PubMed
- Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancersJosh Lewis Stern, Dan Theodorescu, Bert Vogelstein, Nickolas Papadopoulos, Thomas R. Cech · 2015 · Genes & Development
- Properties of a Fetal Multipotent Neural Stem Cell (NEP Cell)Jingli Cai, Yuanyuan Wu, Takumi Mirua, Jeanne L. Pierce, Mary T. Lucero, Kurt H. Albertine, Gerald J. Spangrude, Mahendra S. Rao · 2002 · Developmental Biology
- A Comparison of BTA Stat, Hemoglobin Dipstick, Telomerase and Vysis Urovysion Assays for the Detection of Urothelial Carcinoma in UrineKevin C. Halling, WALTER KING, Irina A Sokolova, Robert Jeffrey Karnes, Reid G. Meyer, Eric L. Powell, Thomas J. Sebo, John C. Cheville, Amy C. Clayton, Kelly L. Krajnik et al. · 2002 · The Journal of Urology
- Urine Markers for Detection and Surveillance of Non–Muscle-Invasive Bladder CancerDerya Tilki A, Maximilian Burger, Guido M. Dalbagni, H. Barton Grossman, Oliver W. Hakenberg, Joan Palou, Oliver M. Reich, Morgan Rouprêt A, Shahrokh François Shariat, Alexandre R. Zlotta · 2011 · European Urology
- Solution Structure of an Intramolecular (3 + 1) Human Telomeric G-Quadruplex Bound to a Telomestatin DerivativeWan Jun Chung, Brahim Heddi, Masayuki Tera, Keisuke Iida, Kazuo Nagasawa, Anh Tuân Phan · 2013 · Journal of the American Chemical Society
- Molecular characteristics of eight gastric cancer cell lines established in JapanH. Yokozaki · 2000 · Pathology international (Print)
- G-Quadruplexes at Telomeres: Friend or Foe?Tracy M. Bryan · 2020 · Molecules
- Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers.Jian Hong Gu, Shunsuke Kagawa, Masahiro Takakura, Satoru Kyo, Masakí Inoue, Jack A. Roth, B Fang · 2000 · PubMed
- Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions.H Tahara, Hiroki Kuniyasu, Hiroshi Yokozaki, Wataru Yasui, J W Shay, Ide T, E Tahara · 1995 · PubMed
- Oxidative guanine base damage regulates human telomerase activityFouquerel, Elise, Lormand, Justin, Bose, Arindam, Lee, Hui-Ting, Kim, Grace S, Li, Jianfeng, Sobol, Robert W, Freudenthal, Bret D, Myong, Sua, Opresko, Patricia L · 2016 · Nature Structural & Molecular Biology
- Human Telomerase RNA Accumulation in Cajal Bodies Facilitates Telomerase Recruitment to Telomeres and Telomere ElongationGaël Cristofari, Emem Adolf, Patrick Reichenbach, Katarzyna O. Sikora, Rebecca M. Terns, Michael P. Terns, Joachim Lingner · 2007 · Molecular Cell
- Tankyrases: Structure, Function and Therapeutic Implications in CancerT. Haikarainen, Stefan Johannes Karl Krauss, L. Lehtiö · 2014 · Current Pharmaceutical Design
- Papillomavirus E6 and E7 proteins and their cellular targetsTrisha Michel Wise-Draper · 2007 · Frontiers in bioscience
- Telomeres and Senescence: Ending the DebateTitia de Lange · 1998 · Science
- Quantitation of hTERT gene expression in sporadic breast tumors with a real-time reverse transcription-polymerase chain reaction assay.Ivan Bièche, Catherine Noguès, Valérie Paradis, Martine Olivi, Pierre Bédossa, Rosette Lidereau, Michel Vidaud · 2000 · PubMed
- Regulation of the human telomerase reverse transcriptase geneAnne‐Lyse Ducrest, Henrietta Szutorisz, Joachim Lingner, Markus Nabholz · 2002 · Oncogene
- Regulation of telomerase by alternate splicing of human telomerase reverse transcriptase (hTERT) in normal and neoplastic ovary, endometrium and myometriumGary A. Ulaner, Ji‐Fan Hu, Thanh H. Vu, Haritha Oruganti, Linda C. Giudice, Andrew R. Hoffman · 2000 · International Journal of Cancer
- Lack of Replicative Senescence in Normal Rodent GliaNicole F. Mathon, Denise S. Malcolm, Marie C. Harrisingh, Lili Cheng, Alison C. Lloyd · 2001 · Science