The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Circuit Simulation of Genetic Networks
Abstract
Genetic networks with tens to hundreds of genes are difficult to analyze with currently available techniques. Because of the many parallels in the function of these biochemically based genetic circuits and electrical circuits, a hybrid modeling approach is proposed that integrates conventional biochemical kinetic modeling within the framework of a circuit simulation. The circuit diagram of the bacteriophage lambda lysis-lysogeny decision circuit represents connectivity in signal paths of the biochemical components. A key feature of the lambda genetic circuit is that operons function as active integrated logic components and introduce signal time delays essential for the in vivo behavior of phage lambda.
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Cites
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The logical analysis of continuous, non-linear biochemical control networks
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Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question
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The OR control system of bacteriophage lambda
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Regulatory networks seen as asynchronous automata: A logical description
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Symbiont Recognition and Subsequent Morphogenesis as Early Events in an Animal-Bacterial Mutualism
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Cited by
From molecular to modular cell biology.
Hartwell, L. H., Hopfield, J. J., Leibler, S., & Murray, A. W. (1999) · Nature · doi:10.1038/35011540 · Cited by 3,632
Kitano, H. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1471 · Cited by 2,278
A N EW A PPROACH TO D ECODING L IFE : Systems Biology
Ideker, T., Galitski, T., & Hood, L. (2001) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.2.1.343 · Cited by 1,664
Modelling and analysis of gene regulatory networks
Karlebach, G., & Shamir, R. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2503 · Cited by 1,296
The New Genomics: Global Views of Biology
Lander, E. S. (1996) · Science · doi:10.1126/science.274.5287.536 · Cited by 1,174
Metadata
- Authors
- McAdams, H. H., & Shapiro, L.
- Venue
- Science
- Published
- 1995-08-04
- Volume
- 269
- Issue
- 5224
- Pages
- 650-656
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1980570931
- Cited by
- 517
- References
- 32
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
