The DOI matches its Crossref record.
Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses
Abstract
The α component of the receptor for ciliary neurotrophic factor (CNTF) differs from other known growth factor receptors in that it is anchored to cell membranes by a glycosylphosphatidylinositol linkage. One possible function of this type of linkage is to allow for the regulated release of this receptor component. Cell lines not normally responsive to CNTF responded to treatment with a combination of CNTF and a soluble form of the CNTF α receptor component. These findings not only demonstrate that the CNTF receptor α chain is a required component of the functional CNTF receptor complex but also reveal that it can function in soluble form as part of a heterodimeric ligand. Potential physiological roles for the soluble CNTF receptor are suggested by its presence in cerebrospinal fluid and by its release from skeletal muscle in response to peripheral nerve injury.
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Citations
Cited by
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“The complex of CNTF and the soluble form of CNTF receptor alpha acts on cells expressing LIFR β and gp130 (95).”
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Jones, S. A., & Jenkins, B. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0066-7 · Cited by 1,102
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Stahl, N., Boulton, T. G., Farruggella, T., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., et al. (1994) · Science · doi:10.1126/science.8272873 · Cited by 979
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Ishihara, K., & Hirano, T. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00321-x · Cited by 122
Kassen, S. C., Thummel, R., Campochiaro, L. A., Harding, M. J., Bennett, N. A., & Hyde, D. R. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.01.007 · Cited by 116
Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
Schaller, S., Buttigieg, D., Alory, A., Jacquier, A., Barad, M., Merchant, M., Gentien, D., de la Grange, P., & Haase, G. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1615372114 · Cited by 34
Nystuen, A., Gonzalez-Lopez, E., Kauper, K. A., Eade, K., & Aaberg, T. M. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.005 · Cited by 11
Metadata
- Authors
- Davis, S., Aldrich, T. H., Ip, N. Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P. S., Curtis, R., Panayotatos, N., Gascan, H., Chevalier, S., & Yancopoulos, G. D.
- Venue
- Science
- Published
- 1993-03-19
- Volume
- 259
- Issue
- 5102
- Pages
- 1736-1739
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148240710
- Cited by
- 350
- References
- 0
- FWCI
- 12.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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