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Cited by 230

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells

Nowak, Mark W., Kearney, Patrick C., Sampson, Saks, Margaret E., Labarca, Cesar G., Silverman, Scott K., Zhong, Wenge, Thorson, Jon, Abelson, John N., Davidson, Norman, Schultz, Peter G., Dougherty, Dennis A., Lester, Henry A.·1995·Science
DOI 10.1126/science.7716551
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Abstract

The nonsense codon suppression method for unnatural amino acid incorporation has been applied to intact cells and combined with electrophysiological analysis to probe structure-function relations in the nicotinic acetylcholine receptor. Functional receptors were expressed in Xenopus oocytes when tyrosine and phenylalanine derivatives were incorporated at positions 93, 190, and 198 in the binding site of the α subunit. Subtle changes in the structure of an individual side chain produced readily detectable changes in the function of this large channel protein. At each position, distinct features of side chain structure dominated the dose-response relation, probably by governing the agonist-receptor binding.

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Metadata

Authors
Nowak, M. W., Kearney, P. C., Sampson, Saks, M. E., Labarca, C. G., Silverman, S. K., Zhong, W., Thorson, J., Abelson, J. N., Davidson, N., Schultz, P. G., Dougherty, D. A., & Lester, H. A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1995-04-21
Volume
268
Issue
5209
Pages
439-442
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.7716551
OpenAlex
W1975744163
Cited by
230
References
2
FWCI
5.21
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells. https://app.cochat.ai/papers/10.1126/science.7716551
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Nowak, M. W., Kearney, P. C., Sampson, Saks, M. E., Labarca, C. G., Silverman, S. K., Zhong, W., Thorson, J., Abelson, J. N., Davidson, N., Schultz, P. G., Dougherty, D. A., & Lester, H. A. (1995). Nicotinic Receptor Binding Site Probed with Unnatural Amino Acid Incorporation in Intact Cells. Science. https://doi.org/10.1126/science.7716551

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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