Unraveling the Burden of Iron in Neurodegeneration: Intersections with Amyloid Beta Peptide Pathology
Open accessAbstract
Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Unbound iron accumulated as a consequence of brain aging is highly reactive with water and oxygen and produces reactive oxygen species (ROS) or free radicals. ROS are toxic compounds able to damage cell membranes, DNA, and mitochondria. Which are the mechanisms involved in neuronal iron homeostasis and in neuronal response to iron‐induced oxidative stress constitutes a cutting‐edge topic in metalloneurobiology. Increasing our knowledge about the underlying mechanisms that operate in iron accumulation and their consequences would shed light on the comprehension of the molecular events that participate in the pathophysiology of the abovementioned neurodegenerative diseases. In this review, current evidences about iron accumulation in the brain, the signaling mechanisms triggered by metal overload, as well as the interaction between amyloid β (A β) and iron, will be summarized.
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When iron is present in the cytosol, dopamine can be oxidized into dopamine quinone (DAQ), which is highly reactive and toxic.
“When iron is present in the cytosol (as may occur more frequently with ageing)265,266, dopamine can be oxidized into dopamine quinone (DAQ), which is highly reactive and toxic267,268.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [266]
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Self-citationβ‐amyloid binds to p75NTR and activates NFκB in human neuroblastoma cells
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Flagged first, then by citations
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Cited by
Sorted by citations
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
- Authors
- Uranga, R. M., & Salvador, G. A.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Uranga, Romina María
- Salvador, Gabriela Alejandra
- Venue
- Oxidative Medicine and Cellular Longevity
- Publisher
- Wiley
- Published
- 2018-01
- Volume
- 2018
- Issue
- 1
- Pages
- 2850341-2850341
- ISSN
- 1942-0994 (ISSN-L)
- 1942-0900
- PMC
- PMC5831758
- OpenAlex
- W2787435117
- Cited by
- 48
- References
- 150
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 3
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Oxidative Medicine and Cellular Longevity (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Agencia Nacional de Promoción Científica y Tecnológica (2013-0987, 2010-936)
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Nacional del Sur (PGI24B/179)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- iron overload, neurodegeneration, amyloid-beta, Alzheimer's disease, Parkinson's disease, Huntington's disease, oxidative stress, reactive oxygen species, iron homeostasis, brain aging
- MeSH terms
- Humans, Iron, Amyloid beta-Peptides, Oxidative Stress, Neurodegenerative Diseases
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