The DOI matches its Crossref record.
Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations
Abstract
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody concentrations. Analysis of total IgE within a subset of 128 IgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1, especially to the interleukin-4 gene ( IL4 ). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates IgE production in a nonantigen-specific (noncognate) fashion.
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An IL-13 promoter polymorphism associated with increased risk of allergic asthma
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Grant, A. V., Araujo, M. I., Ponte, E. V., Oliveira, R. R., Cruz, A. A., Barnes, K. C., & Beaty, T. H. (2008) · The Journal of Infectious Diseases · doi:10.1086/591946 · Cited by 29
Self-citation
Metadata
- Authors
- Marsh, D. G., Neely, J. D., Breazeale, D. R., Ghosh, B., Freidhoff, L. R., Ehrlich-Kautzky, E., Schou, C., Krishnaswamy, G., & Beaty, T. H.
- Venue
- Science
- Published
- 1994-05-20
- Volume
- 264
- Issue
- 5162
- Pages
- 1152-1156
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094472942
- Cited by
- 1,003
- References
- 0
- FWCI
- 36.96
- Type
- journal article
- Language
- en
- Open access
- closed
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