Cited by 255T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Signaling pathways in Th2 development

Mowen, Kerri A., Glimcher, Laurie H.·2004·Immunological Reviews

Abstract

In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.

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Crossref · 10.1111/j.0105-2896.2004.00209.x

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Authors
Mowen, K. A., & Glimcher, L. H.
Affiliations
Harvard University (US)
Corresponding author
Mowen, Kerri A.
Venue
Immunological Reviews
Publisher
Wiley
Published
2004-11-11
Volume
202
Issue
1
Pages
203-222
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2023488690
Cited by
255
References
294
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 11 · 2013: 12 · 2012: 11
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
Keywords
Th2 cells, T helper cell differentiation, signal transduction, Th1 cells, cell-mediated immunity, humoral immunity, intracellular pathogens, extracellular pathogens
MeSH terms
Animals, Cell Differentiation, Dendritic Cells, Digestive System, Humans, Transcription Factors, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Th2 Cells, Mice

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