Signaling pathways in Th2 development
Abstract
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
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The STAT6 signaling pathway is mainly induced by IL-4, which induces the expression of GATA3.
“The STAT6 signaling pathway is mainly induced by IL-4, which induces the expression of GATA3 [31, 40].”
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- Authors
- Mowen, K. A., & Glimcher, L. H.
- Affiliations
- Harvard University (US)
- Corresponding author
- Mowen, Kerri A.
- ORCID
- Glimcher, Laurie H.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 202
- Issue
- 1
- Pages
- 203-222
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2023488690
- Cited by
- 255
- References
- 294
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 10 · 2018: 3 · 2017: 7 · 2016: 10 · 2015: 4 · 2014: 11 · 2013: 12 · 2012: 11
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- Th2 cells, T helper cell differentiation, signal transduction, Th1 cells, cell-mediated immunity, humoral immunity, intracellular pathogens, extracellular pathogens
- MeSH terms
- Animals, Cell Differentiation, Dendritic Cells, Digestive System, Humans, Transcription Factors, Signal Transduction, T-Lymphocyte Subsets, Cytokines, Th2 Cells, Mice
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