Cited by 814Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathwaysinterferon and immune responses

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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Lütticken, Claudia, Wegenka, Ursula M., Yuan, Juping, Buschmann, Jan, Schindler, Chris, Ziemiecki, Andrew, Harpur, Ailsa G., Wilks, Andrew F., Yasukawa, Kiyoshi, Taga, Tetsuya, Kishimoto, Tadamitsu, Barbieri, Giovanna, Pellegrini, Sandra, Sendtner, Michael, Heinrich, Peter C., Horn, Friedemann·1994·Science

DOI 10.1126/science.8272872

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Abstract

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3α (ISGF-3α). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3α p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.

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“Therefore, the inhibition of IL-6-induced activation of STAT3 could be a good tool for screening effective therapeutic materials as well as target drugs for the treatment of diseases related to IL-6, including rheumatoid arthritis, atherosclerosis, diabetes, cancer and multiple myeloma [15].”
Method
Association between STAT3 polymorphisms and cancer risk: a meta-analysis
Yan, R.-C., Lin, F.-S., Hu, C., & Tong, S.-L. (2015) · Zeitschrift für Induktive Abstammungs- und Vererbungslehre · doi:10.1007/s00438-015-1074-y · Cited by 12
“STAT3, a member of a transcription factor family, was first identified in 1994 as an IL-6-activated acute-phase response factor (APRF) (Lutticken et al. 1994).”
Background
Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells.
Huang, Y., Hung, W., Kang, W., Chen, W.-T., & Chai, C. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.06.009 · Cited by 12
Response to IL-6 of HPV-18 Cervical Carcinoma Cell Lines
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Mechanism of the impairment of the glucagon‐stimulated phosphoenolpyruvate carboxykinase gene expression by interleukin‐6 in rat hepatocytes: Inhibition of the increase in cyclic 3′,5′ adenosine monophosphate and the downstream cyclic 3′,5′ adenosine monophosphate action
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Inhibition of HIV Type 1 Tat-Mediated trans-Activation by Oncostatin M in HLtat Cells
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“and translocate into the nucleus where they activate transcription of IL-6-inducible genes, such as acute-phase genes [5, 6].”
Background
The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters
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“STAT3, known as the acute-phase response element, was first described in hepatocytes (1,2) and can be activated by the interleukin-6 (IL-6) cytokine family, type I interferon and epidermal growth factor (EGF) (3,4).”
Background
Characterization of receptors for ciliary neurotrophic factor on rat hippocampal astrocytes.
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“IL-6 also uses the gp130-JAK-STAT (STAT3) signal transduction pathway and activates the APRE (14, 15).”
BackgroundMethod
The Amino Acid Residues Immediately Carboxyl-terminal to the Tyrosine Phosphorylation Site Contribute to Interleukin 6-specific Activation of Signal Transducer and Activator of Transcription 3
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Self-citation
MOLECULAR BIOLOGY OF CYTOKINES IN ALLERGIC DISEASES AND ASTHMA
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Biosynthetic and glycosylation events of the IL‐6 receptor β‐Subunit, gp130
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MiR-147a mediated by sodium new houttuyfonate could enhance radiosensitivity of non-small cell lung cancer cells via suppressing STAT3.
Dai, K.-J., Chen, L., Liu, J., Ding, Y., Gu, C., & Lu, X.-J. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/130599 · Cited by 10
A single nucleotide polymorphism in the 3′-UTR ofSTAT3regulates its expression and reduces risk of pancreatic cancer in a Chinese population
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“STAT3, a member of a transcription factor family, was first identified in 1994 as an IL-6-activated acute-phase response factor (APRF) [38].”
Background
Ethyl acetate extract of Hypericum japonicum induces apoptosis via the mitochondria-dependent pathway in vivo and in vitro
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“Apoptotic cell death is recognizable by cellular morphological characteristics, including membrane blebbing and chromatin condensation (18).”
Inhibition of the Jak-STAT pathway prevents CNTF-mediated survival of axotomized oxytocinergic magnocellular neurons in organotypic cultures of the rat supraoptic nucleus
Askvig, J. M., Lo, D. Y., Sudbeck, A., Behm, K. E., Leiphon, L. J., & Watt, J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.023 · Cited by 10
“, 1993), is phosphorylated by Jak molecules (Lutticken et al., 1994).”
BackgroundResult
Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population
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“The Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway transmit signals of a wide range of cytokines, growth factors, and hormones and it has been shown to mediate hypertrophic and cytoprotective effects of gp130 activation in cardiomyocytes [12–18].”
Background
Interleukin-11, an IL-6-like cytokine
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Co-activator SRC-1 is dispensable for transcriptional control by STAT3.
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Self-citation
Cell swelling activates STAT1 and STAT3 proteins in cultured rat hepatocytes
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Self-citation
Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator
Molitor, T. P., Hayashi, G., Lin, M.-Y., Dunn, C. J., Peterson, N. G., Poston, R. G., Kurnellas, M., Traver, D., Patel, S., Akgungor, Z., et al. (2025) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.2422172122 · Cited by 9
“Compound selectivity profiles against other JAK family members were measured via IL - 6 - induced pSTAT3 (17, 18) and GM - CSF - induced pSTAT5 abundance (19, 20); IC 50 s summarized in Table 1.”
Age‐associated myeloid malignancies – the role of STAT3 and STAT5 in myelodysplastic syndrome and acute myeloid leukemia
Fasouli, E. S., & Katsantoni, E. Z. (2024) · FEBS Letters · doi:10.1002/1873-3468.14985 · Cited by 12
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis
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Dynamic Changes in pStat3 Are Involved in Meiotic Spindle Assembly in Mouse Oocytes
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Pro-inflammatory cytokines in patients with chronic kidney disease: interleukin-6 in focus
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Silencing of CXCL12 performs a protective effect on C5b-9-induced injury in podocytes
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Interaction of Notch and gp130 Signaling in the Maintenance of Neural Stem and Progenitor Cells
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Activation of signal transducers and activators of transcription 3 in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning
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Alkamides from Piper longum and Piper nigrum as Inhibitors of IL-6 action
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Transactivation of gp130 in Myeloma Cells 1
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EXPRESSION AND REGULATION OF GP130 MESSENGER RIBONUCLEIC ACID IN CULTURED IMMATURE RAT SEROLI CELLS
Fujisawa, M., Okuda, Y., Fujioka, H., & Kamidono, S. (2002) · doi:10.1081/erc-120004532 · Cited by 9
“Binding of these cytokines to their specific cell-surface receptors results in tyrosine phosphorylation of gp130 by members of the Janus kinase (JAK) family of tyrosine kinases (3) and subsequent tyrosine phosphorylation of several downstream signaling molecules including members of the signal transducers and activato…”
Background

Authors: Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., Kishimoto, T., Barbieri, G., Pellegrini, S., Sendtner, M., Heinrich, P. C., & Horn, F.
Affiliations: RWTH Aachen University (DE)
ORCID: Yuan, Juping
Wilks, Andrew F.
Yasukawa, Kiyoshi
Taga, Tetsuya
Kishimoto, Tadamitsu
Barbieri, Giovanna
Pellegrini, Sandra
Sendtner, Michael
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1994-01-07
Volume: 263
Issue: 5143
Pages: 89-92
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8272872
OpenAlex: W1999028040
Cited by: 814
References: 0
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 17 · 2015: 23 · 2014: 15 · 2013: 15 · 2012: 20
FWCI: 38.85
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: JAK1, gp130, IL-6 signaling, cytokine-receptor complex, tyrosine phosphorylation, transcription factor activation, leukemia inhibitory factor, oncostatin M, interleukin-11, ciliary neurotrophic factor, signal transduction
MeSH terms: Base Sequence, DNA-Binding Proteins, Humans, Interferon-gamma, Membrane Glycoproteins, Molecular Sequence Data, Phosphorylation, Protein-Tyrosine Kinases, Transcription Factors, Tumor Cells, Cultured, Tyrosine, Signal Transduction, Trans-Activators, Antigens, CD, Interleukin-6, Cytokines, STAT1 Transcription Factor, STAT3 Transcription Factor, Cytokine Receptor gp130, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Janus Kinase 1

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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

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