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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Lütticken, Claudia, Wegenka, Ursula M., Yuan, Juping, Buschmann, Jan, Schindler, Chris, Ziemiecki, Andrew, Harpur, Ailsa G., Wilks, Andrew F., Yasukawa, Kiyoshi, Taga, Tetsuya, Kishimoto, Tadamitsu, Barbieri, Giovanna, Pellegrini, Sandra, Sendtner, Michael, Heinrich, Peter C., Horn, Friedemann·1994·Science

DOI 10.1126/science.8272872

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Abstract

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3α (ISGF-3α). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3α p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.

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Authors: Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., Kishimoto, T., Barbieri, G., Pellegrini, S., Sendtner, M., Heinrich, P. C., & Horn, F.
Affiliations: RWTH Aachen University (DE)
ORCID: Yuan, Juping
Wilks, Andrew F.
Yasukawa, Kiyoshi
Taga, Tetsuya
Kishimoto, Tadamitsu
Barbieri, Giovanna
Pellegrini, Sandra
Sendtner, Michael
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1994-01-07
Volume: 263
Issue: 5143
Pages: 89-92
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.8272872
OpenAlex: W1999028040
Cited by: 814
References: 0
Citations by year: 2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 17 · 2015: 23 · 2014: 15 · 2013: 15 · 2012: 20
FWCI: 38.85
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords: JAK1, gp130, IL-6 signaling, cytokine-receptor complex, tyrosine phosphorylation, transcription factor activation, leukemia inhibitory factor, oncostatin M, interleukin-11, ciliary neurotrophic factor, signal transduction
MeSH terms: Base Sequence, DNA-Binding Proteins, Humans, Interferon-gamma, Membrane Glycoproteins, Molecular Sequence Data, Phosphorylation, Protein-Tyrosine Kinases, Transcription Factors, Tumor Cells, Cultured, Tyrosine, Signal Transduction, Trans-Activators, Antigens, CD, Interleukin-6, Cytokines, STAT1 Transcription Factor, STAT3 Transcription Factor, Cytokine Receptor gp130, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Janus Kinase 1

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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

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