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Cited by 814Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathwaysinterferon and immune responses

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Lütticken, Claudia, Wegenka, Ursula M., Yuan, Juping, Buschmann, Jan, Schindler, Chris, Ziemiecki, Andrew, Harpur, Ailsa G., Wilks, Andrew F., Yasukawa, Kiyoshi, Taga, Tetsuya, Kishimoto, Tadamitsu, Barbieri, Giovanna, Pellegrini, Sandra, Sendtner, Michael, Heinrich, Peter C., Horn, Friedemann·1994·Science
DOI 10.1126/science.8272872
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Abstract

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase response factor (APRF), a protein antigenically related to the p91 subunit of the interferon-stimulated gene factor-3α (ISGF-3α). These cytokines caused tyrosine phosphorylation of APRF and ISGF-3α p91. Protein kinases of the Jak family were also rapidly tyrosine phosphorylated, and both APRF and Jak1 associated with gp130. These data indicate that Jak family protein kinases may participate in IL-6 signaling and that APRF may be activated in a complex with gp130.

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Research works printed but not linked: 30

  1. 10.1016/0092-8674(93)90415-M · DOI
  2. BAZAN, J.F., NEUROPOIETIC CYTOKINES IN THE HEMATOPOIETIC FOLD, NEURON 7: 197 (1991). · DOI
  3. BAZAN, J.F., STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 87: 6934 (1990).
  4. COOPER, J.A., DETECTION AND QUANTIFICATION OF PHOSPHOTYROSINE IN PROTEINS, METHODS IN ENZYMOLOGY 99: 387 (1983). · DOI
  5. 10.1126/science.8390097 · DOI
  6. DECKER, T, CYTOPLASMIC ACTIVATION OF GAF, AN IFN-GAMMA-REGULATED DNA-BINDING FACTOR, EMBO JOURNAL 10: 927 (1991). · DOI
  7. FIRMBACHKRAFT, I, TYK2, PROTOTYPE OF A NOVEL CLASS OF NONRECEPTOR TYROSINE KINASE GENES, ONCOGENE 5: 1329 (1990).
  8. FU, X.Y., TRANSCRIPTION FACTOR P91 INTERACTS WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND MEDIATES ACTIVATION OF THE C-FOS GENE PROMOTER, CELL 74: 1135 (1993). · DOI
  9. 10.1126/science.1542794 · DOI
  10. HIBI, M, MOLECULAR-CLONING AND EXPRESSION OF AN IL-6 SIGNAL TRANSDUCER, GP130, CELL 63: 1149 (1990). · DOI · Paper page
  11. Hibi, M., Cell 63: 1149 (1990). · DOI · Paper page
  12. 10.1126/science.8378773 · DOI
  13. 10.1126/science.8511589 · DOI
  14. PATTERSON, P.H., NEURONAL DIFFERENTIATION FACTORS CYTOKINES AND SYNAPTIC PLASTICITY, CELL 72: 123 (1993). · DOI
  15. PELLEGRINI, S, EARLY EVENTS IN SIGNALING BY INTERFERONS, TRENDS IN BIOCHEMICAL SCIENCES 18: 338 (1993). · DOI
  16. 10.1126/science.8378774 · DOI
  17. 10.1126/science.8397445 · DOI
  18. SCHINDLER, C, PROTEINS OF TRANSCRIPTION FACTOR ISGF-3 - ONE GENE ENCODES THE 91-KDA AND 84-KDA ISGF-3 PROTEINS THAT ARE ACTIVATED BY INTERFERON-ALPHA, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89: 7836 (1992).
  19. 10.1126/science.1496401 · DOI · Paper page
  20. 10.1126/science.1281555 · DOI
  21. 10.1126/science.7690989 · DOI · Paper page
  22. SILVENNOINEN, O, STRUCTURE OF THE MURINE JAK2 PROTEIN-TYROSINE KINASE AND ITS ROLE IN INTERLEUKIN-3 SIGNAL-TRANSDUCTION, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 90: 8429 (1993).
  23. STAHL, N, THE ALPHAS, BETAS, AND KINASES OF CYTOKINE RECEPTOR COMPLEXES, CELL 74: 587 (1993). · DOI
  24. 10.1016/0092-8674(92)90105-L · DOI
  25. WEGENKA, U.M., ACUTE-PHASE RESPONSE FACTOR, A NUCLEAR FACTOR BINDING TO ACUTE-PHASE RESPONSE ELEMENTS, IS RAPIDLY ACTIVATED BY INTERLEUKIN-6 AT THE POSTTRANSLATIONAL LEVEL, MOLECULAR AND CELLULAR BIOLOGY 13: 276 (1993).
  26. WILKS, A.F., 2 NOVEL PROTEIN-TYROSINE KINASES, EACH WITH A 2ND PHOSPHOTRANSFERASE-RELATED CATALYTIC DOMAIN, DEFINE A NEW CLASS OF PROTEIN-KINASE, MOLECULAR AND CELLULAR BIOLOGY 11: 2057 (1991).
  27. WITTHUHN, B.A., JAK2 ASSOCIATES WITH THE ERYTHROPOIETIN RECEPTOR AND IS TYROSINE-PHOSPHORYLATED AND ACTIVATED FOLLOWING STIMULATION WITH ERYTHROPOIETIN, CELL 74: 227 (1993). · DOI
  28. YOSHIMURA, A, INVITRO PHOSPHORYLATION OF THE ERYTHROPOIETIN RECEPTOR AND AN ASSOCIATED PROTEIN, PP130, MOLECULAR AND CELLULAR BIOLOGY 12: 706 (1992).
  29. Yuan, J., Molecular and Cellular Biology 14: 1657 (1994).
  30. Ip, N. Y., Cell 69: 1121 (1992). · DOI

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Metadata

Authors
Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., Kishimoto, T., Barbieri, G., Pellegrini, S., Sendtner, M., Heinrich, P. C., & Horn, F.
Affiliations
RWTH Aachen University (DE)
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1994-01-07
Volume
263
Issue
5143
Pages
89-92
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.8272872
OpenAlex
W1999028040
Cited by
814
References
0
Citations by year
2026: 4 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 17 · 2015: 23 · 2014: 15 · 2013: 15 · 2012: 20
FWCI
38.85
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Keywords
JAK1, gp130, IL-6 signaling, cytokine-receptor complex, tyrosine phosphorylation, transcription factor activation, leukemia inhibitory factor, oncostatin M, interleukin-11, ciliary neurotrophic factor, signal transduction
MeSH terms
Base Sequence, DNA-Binding Proteins, Humans, Interferon-gamma, Membrane Glycoproteins, Molecular Sequence Data, Phosphorylation, Protein-Tyrosine Kinases, Transcription Factors, Tumor Cells, Cultured, Tyrosine, Signal Transduction, Trans-Activators, Antigens, CD, Interleukin-6, Cytokines, STAT1 Transcription Factor, STAT3 Transcription Factor, Cytokine Receptor gp130, Interferon-Stimulated Gene Factor 3, Interferon-Stimulated Gene Factor 3, gamma Subunit, Janus Kinase 1

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