Kishimoto, Tadamitsu

IL‐6 in inflammation, immunity, and disease

Tanaka, T., Narazaki, M., & Kishimoto, T. (2014) · Cold Spring Harbor Perspectives in Biology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 5,046

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

Komori, T., Yagi, H., Nomura, S., Yamaguchi, A., Sasaki, K., Deguchi, K., Shimizu, Y., Bronson, R. T., Gao, Y.-H., Inada, M., et al. (1997) · Cell

Bone Metabolism and DiseasesAlkaline Phosphatase Research Studies

Cited by 4,244

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 2,139

Impaired immune and acute-phase responses in interleukin-6-deficient mice

Kopf, M., Baumann, H., Freer, G., Freudenberg, M., Lamers, M., Kishimoto, T., Zinkernagel, R., Bluethmann, H., & Köhler, G. (1994) · Nature

Cytokine Signaling Pathways and InteractionsImmune Response and Inflammation

Cited by 1,768

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature

Multiple Myeloma Research and TreatmentsCytokine Signaling Pathways and Interactions

Cited by 1,633

Essential role of Stat6 in IL-4 signalling

Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S.-I., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996) · Nature

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 1,557

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 1,396

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsDevelopmental Biology and Gene Regulation

Cited by 1,323

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo

Atreya, R., Mudter, J., Finotto, S., Müllberg, J., Jostock, T., Wirtz, S., Schütz, M., Bartsch, B., Holtmann, M., Becker, C., et al. (2000) · Nature Medicine

Inflammatory Bowel DiseaseCytokine Signaling Pathways and Interactions

Cited by 1,293

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell

Cytokine Signaling Pathways and Interactionsinterferon and immune responses

Cited by 1,019

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences

NF-κB Signaling PathwaysGenomics and Chromatin Dynamics

Cited by 959

Targeting Interleukin-6 Signaling in Clinic

Kang, S., Tanaka, T., Narazaki, M., & Kishimoto, T. (2019) · Immunity

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 904

IL-6: From its discovery to clinical applications

Kishimoto, T. (2010) · International Immunology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 846

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Lütticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., et al. (1994) · Science

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 814

Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

Maini, R. N., Taylor, P. C., Szechinski, J., Pavelka, K., Bröll, J., Balint, G., Emery, P., Raemen, F., Petersen, J., Smolen, J., et al. (2006) · Arthritis & Rheumatism

Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders Research

Cited by 790

Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial

Yokota, S., Imagawa, T., Mori, M., Miyamae, T., Aihara, Y., Takei, S., Iwata, N., Umebayashi, H., Murata, T., Miyoshi, M., et al. (2008) · The Lancet

Autoimmune and Inflammatory Disorders ResearchRheumatoid Arthritis Research and Therapies

Cited by 789

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology

Rheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and Interactions

Cited by 784

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells

Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 783

Humanized anti–interleukin-6 receptor antibody treatment of multicentric Castleman disease

Nishimoto, N., Kanakura, Y., Aozasa, K., Johkoh, T., Nakamura, M., Nakano, S., Nakano, N., Ikeda, Y., Sasaki, T., Nishioka, K., et al. (2005) · Blood

Viral-associated cancers and disordersAutoimmune and Inflammatory Disorders Research

Cited by 754

TGF-β Suppresses Tumor Progression in Colon Cancer by Inhibition of IL-6 trans-Signaling

Becker, C., Fantini, M. C., Schramm, C., Lehr, H. A., Wirtz, S., Nikolaev, A., Burg, J., Strand, S., Kiesslich, R., Huber, S., et al. (2004) · Immunity

TGF-β signaling in diseasesCytokine Signaling Pathways and Interactions

Cited by 726

IgG1 plasmacytosis in interleukin 6 transgenic mice

Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences

Multiple Myeloma Research and TreatmentsLymphoma Diagnosis and Treatment

Cited by 586

Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S. (1998) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 584

Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis: a randomized, double-blind, placebo-controlled, dose-escalation trial

Choy, E. H. S., Isenberg, D. A., Garrood, T., Farrow, S., Ioannou, Y., Bird, H., Cheung, N., Williams, B., Hazleman, B., Price, R., et al. (2002) · Arthritis & Rheumatism

Rheumatoid Arthritis Research and TherapiesAutoimmune and Inflammatory Disorders Research

Cited by 526

IL-6 is required for the development of Th1 cell-mediated murine colitis

Yamamoto, M., Yoshizaki, K., Kishimoto, T., & Ito, H. (2000) · The Journal of Immunology

Inflammatory Bowel DiseasePsoriasis: Treatment and Pathogenesis

Cited by 411