The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Zinc Finger Phage: Affinity Selection of Fingers with New DNA-Binding Specificities
Abstract
A phage display system was developed and used to select zinc finger proteins with altered DNA-binding specificities. The three zinc fingers of the Zif268 protein were expressed on the surface of filamentous phage, and a library of variants was prepared by randomizing critical amino acids in the first zinc finger. Affinity selections, using DNA sites with base changes in the region recognized by the first finger, yielded Zif268 variants that bound tightly and specifically to the new sites. This phage system provides a tool for the study of protein-DNA interactions and may offer a general method for selecting zinc finger proteins that recognize desired target sites on double-stranded DNA.
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Citations
Cites
Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers
Pavletich, N. P., & Pabo, C. O. (1993) · Science · doi:10.1126/science.8378770 · Cited by 669
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Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S., & Gregory, P. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2842 · Cited by 2,285
Self-citationHybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.
Kim, Y. G., Cha, J., & Chandrasegaran, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1156 · Cited by 1,889
DNA Recognition by Cys2His2 Zinc Finger Proteins
Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.29.1.183 · Cited by 1,053
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Kim, H. J., Lee, H. J., Kim, H., Cho, S. W., & Kim, J.-S. (2009) · Genome Research · doi:10.1101/gr.089417.108 · Cited by 466
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Self-citationSegal, D. J., Dreier, B., Beerli, R. R., & Barbas, C. F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.2758 · Cited by 374
In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence
Choo, Y., Sánchez-García, I., & Klug, A. (1994) · Nature · doi:10.1038/372642a0 · Cited by 292
Design of polydactyl zinc-finger proteins for unique addressing within complex genomes
Liu, Q., Segal, D. J., Ghiara, J. B., & Barbas, C. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5525 · Cited by 288
Structure-Based Design of Transcription Factors
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Metadata
- Authors
- Rebar, E. J., & Pabo, C. O.
- Venue
- Science
- Published
- 1994-02-04
- Volume
- 263
- Issue
- 5147
- Pages
- 671-673
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2041659572
- Cited by
- 417
- References
- 1
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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