The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA
Abstract
Rat C6 glioma cells express insulin-like growth factor I (IGF-I) and form rapidly growing tumors in syngeneic animals. When transfected with an episome-based vector encoding antisense IGF-I complementary DNA, these cells lost tumorigenicity. Subcutaneous injection of IGF-I antisense-transfected C6 cells into rats prevented formation of both subcutaneous tumors and brain tumors induced by nontransfected C6 cells. The antisense-transfected cells also caused regression of established brain glioblastomas when injected at a point distal to the tumor. These antitumor effects result from a glioma-specific immune response involving CD8 + lymphocytes. Antisense blocking of IGF-I expression may reverse a phenotype that allows C6 glioma cells to evade the immune system.
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Cited by
Gli and hedgehog in cancer: tumours, embryos and stem cells
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The role of the insulin-like growth factors in the central nervous system
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Metadata
- Authors
- Trojan, J., Johnson, T. R., Rudin, S. D., Ilan, J., Tykocinski, M. L., & Ilan, J.
- Venue
- Science
- Published
- 1993-01
- Volume
- 259
- Issue
- 5091
- Pages
- 94-97
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076479500
- Cited by
- 329
- References
- 17
- FWCI
- 27.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trojan, J., Johnson, T. R., Rudin, S. D., Ilan, J., Tykocinski, M. L., & Ilan, J. (1993). Treatment and Prevention of Rat Glioblastoma by Immunogenic C6 Cells Expressing Antisense Insulin-Like Growth Factor I RNA. Science. https://doi.org/10.1126/science.8418502
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
