The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine
Abstract
Although protection in animal models against intravenous challenges with simian immunodeficiency virus (SIV) has been reported, no previous vaccines have protected against a heterosexual route of infection. In this study, five of six macaques were protected against vaginal challenge when immunized with formalin-treated SIV in biodegradable microspheres by the intramuscular plus oral or plus intratracheal route. Oral immunization alone did not protect. After a second vaginal challenge, three of four intramuscularly primed and mucosally boosted macaques remained protected. The data suggest that protection against human immunodeficiency virus vaginal transmission could be provided by microsphere-based booster vaccines when used to immunize women who are systemically primed.
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Cites
Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene
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Cellular Proteins Bound to Immunodeficiency Viruses: Implications for Pathogenesis and Vaccines
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Biodegradable microspheres as a vaccine delivery system
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Self-citation
Cited by
Singh, M., & O'Hagan, D. (1999) · Nature Biotechnology · doi:10.1038/15058 · Cited by 506
Progesterone implants enhance SIV vaginal transmission and early virus load
Marx, P. A., Spira, A. I., Gettie, A., Dailey, P. J., Veazey, R. S., Lackner, A. A., Mahoney, C. J., Miller, C. J., Claypool, L. E., Ho, D. D., et al. (1996) · Nature Medicine · doi:10.1038/nm1096-1084 · Cited by 465
Self-citationRecent developments in adjuvants for vaccines against infectious diseases
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Microparticles as vaccine adjuvants and delivery systems
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Metadata
- Authors
- Marx, P. A., Compans, R. W., Gettie, A., Staas, J. K., Gilley, R. M., Mulligan, M. J., Yamshchikov, G. V., Chen, D., & Eldridge, J. H.
- Venue
- Science
- Published
- 1993-05-28
- Volume
- 260
- Issue
- 5112
- Pages
- 1323-1327
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054827263
- Cited by
- 261
- References
- 29
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Marx, P. A., Compans, R. W., Gettie, A., Staas, J. K., Gilley, R. M., Mulligan, M. J., Yamshchikov, G. V., Chen, D., & Eldridge, J. H. (1993). Protection Against Vaginal SIV Transmission with Microencapsulated Vaccine. Science. https://doi.org/10.1126/science.8493576
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
