The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
Abstract
Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A subsequent point mutation introduced a novel splice donor site, resulting in a new coding exon and a truncated protein with distinct functional properties.”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“It is predominantly expressed in basal progenitor cells within the developing human neocortex.”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“Ectopic expression of ARHGAP11B in the embryonic mouse neocortex has been shown to increase the number of basal progenitors and induce cortical folding (gyrification), a feature absent in the lissencephalic (smooth) mouse brain.”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“These findings suggest that ARHGAP11B played a pivotal role in the evolutionary expansion and increased complexity of the human neocortex [54].”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“ARHGAP11B is a human-specific gene that originated approximately 5 million years ago through a partial duplication of the ancestral gene ARHGAP11A.”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“Its expression promotes the proliferation of these progenitors, leading to an increased pool of neurons and contributing to the expansion of the neocortical surface area—a hallmark of the human brain.”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“For instance, introducing ARHGAP11B into murine neuronal progenitors using gene editing or overexpression systems induced an expansion similar to that observed in the human cortex, suggesting a causal role in cognitive enhancement [54].”
From Origin and Evolution of Genes in Eukaryotes: Mechanisms, Dynamics, and Functional Implications (2025) · cites this paper as [54]
In the citing paper
“Of the genes that were preferentially expressed in human RG cells compared to iPCs and neurons, 56 lacked a mouse ortholog.”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Florio et al., 2015
Citations
Cites
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889
The complete genome sequence of a Neanderthal from the Altai Mountains
Prüfer, K., Racimo, F., Patterson, N., Jay, F., Sankararaman, S., Sawyer, S., Heinze, A., Renaud, G., Sudmant, P. H., de Filippo, C., et al. (2014) · Nature · doi:10.1038/nature12886 · Cited by 2,254
Self-citationA high-coverage genome sequence from an archaic denisovan individual
Meyer, M., Kircher, M., Gansauge, M.-T., Li, H., Racimo, F., Mallick, S., Schraiber, J. G., Jay, F., Prüfer, K., de Filippo, C., et al. (2012) · Science · doi:10.1126/science.1224344 · Cited by 1,967
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342
Transcriptional landscape of the prenatal human brain
Miller, J. A., Ding, S.-L., Sunkin, S. M., Smith, K. A., Ng, L., Szafer, A., Ebbert, A., Riley, Z. L., Royall, J. J., Aiona, K., et al. (2014) · Nature · doi:10.1038/nature13185 · Cited by 1,325
Englund, C., Fink, A., Lau, C., Pham, D., Daza, R. A. M., Bulfone, A., Kowalczyk, T., & Hevner, R. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2899-04.2005 · Cited by 1,261
Haubensak, W. E., Attardo, A., Denk, W. T., & Huttner, W. Β. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308600100 · Cited by 1,004
Pollen, A. A., Nowakowski, T. J., Shuga, J., Wang, X., Leyrat, A. A., Lui, J. H., Li, N., Szpankowski, L., Fowler, B., Chen, P., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2967 · Cited by 920
Taverna, E., Götz, M., & Huttner, W. Β. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155801 · Cited by 780
Flagged first, then by citations
Cited by
Sorted by citations
Items 501–600 of 634
A historical and technological perspective on the evolution of the human brain transcriptome
Risgaard, R. D., Doll, H. M., & Sousa, A. M. M. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00053-1 · Cited by 1
Li, T., Mo, F., Qi, J., Li, C., Li, X., Zhang, J., Lu, Y., Yao, C., Zhang, L., Hu, B., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf125 · Cited by 1
Toro, R., & Heuer, K. (2025) · Evolution of Nervous Systems · doi:10.1016/b978-0-443-27380-3.00039-7 · Cited by 1
Basal progenitors as drivers of neocortical expansion
Barão, S., & Müller, U. (2026) · Trends in Neurosciences · doi:10.1016/j.tins.2025.12.007 · Cited by 1
Simply complex – the structure of the cerebellar neuronal lineage
Butts, T., & Wingate, R. J. T. (2026) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2026.01.012 · Cited by 1
Mechanical impact on neural stem cell lineage decisions in human brain organoids
Lampersperger, H., Tranchina, M., Meth, B., Han, D., Nayebzadeh, N., Reiter, N., Kuth, S., Lorke, M., Boccaccini, A. R., Budday, S., et al. (2026) · EMBO Reports · doi:10.1038/s44319-026-00719-2 · Cited by 2
Yoshino, M., Mosiagina, A. I., Sano, D., Dei, R., Yoshida, M., & Kawasaki, H. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1803021 · Cited by 1
Arístide, L. (2026) · Brain Behavior and Evolution · doi:10.1159/000552655 · Cited by 1
Zhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.021 · Cited by 1
Building brains that can evolve: Challenges and prospects for evo-devo neurobiology
Striedter, G. F. (2016) · Mètode: Revista de difusió de la investigació de la Universitat de Valencia · doi:10.7203/metode.7.7185 · Cited by 1
Leben, Evolution und Information
Johannsen, W. (2016) · Springer eBooks · doi:10.1007/978-3-662-50255-6_5 · Cited by 1
Combining Genetic and Developmental Methods to Study Musculoskeletal Evolution in Primates
Capellini, T. D., & Dingwall, H. L. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316388907.009 · Cited by 1
Genetic bases of human unique traits
Luo, X., ZHANG, D., & Su, B. (2017) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972016-01063
Long, K. R., & Huttner, W. Β. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00011-4 · Cited by 1
David, F., Stachowiak, E. K., & Stachowiak, M. K. (2020) · Translational Neuroscience Research and Reviews · doi:10.36959/817/526 · Cited by 2
Smith, M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15352-5.00002-9 · Cited by 1
Hongo, I., Yamaguchi, C., & Okamoto, H. (2024) · Cells and Development · doi:10.1016/j.cdev.2024.203918 · Cited by 1
Evolution of functional sulcal anatomy in primates
Arcaro, M. J., Willbrand, E. H., Amiez, C., Maboudian, S. A., & Weiner, K. S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00029-4 · Cited by 1
Take Pax6 for a Cortical 6-Pack
Roberts, R. G. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002218 · Cited by 1
Juan, D., García-Pérez, R., Esteller-Cucala, P., Martín, G. M., Lobón, I., Carlo, V. D., Riera, M., Kuhlwilm, M., Navarro, A., Blancher, A., et al. (2020) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · Cited by 1
Cerebral Organoids: A Model of Brain Development
Sukhinich, K. K., & Aleksandrova, M. A. (2020) · Russian Journal of Developmental Biology · doi:10.1134/s1062360420040074 · Cited by 1
Use of iPSC-derived brain organoids to study human brain evolution
Reiner, O., Sapir, T., & Parichha, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822231-7.00012-6 · Cited by 1
Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection
Shull, G. M., Haffner, C., Huttner, W. Β., Taverna, E., & Kodandaramaiah, S. B. (2021) · Journal of Visualized Experiments · doi:10.3791/61599-v · Cited by 1
RETRACTED: Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/ Cas9 system
Liu, Y., Jin, Y., Chen, T., Wu, Y., Peng, X., Li, W., Wei, S. H., Chen, M., Zou, Q., Guo, S., et al. (2022) · Stem Cell Research · doi:10.1016/j.scr.2022.102764 · Cited by 1
RetractedCell biology of neuronal progenitor cells
Temple, S., Bai, Q., & Shen, Q. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00012-6 · Cited by 1
Intelligence: Evolutionary Biological Foundations and Perspectives
Holstein, T. W. (2022) · Springer eBooks · doi:10.1007/978-3-031-04198-3_5 · Cited by 1
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Li, C., Feng, Y., Fu, Z., Deng, J., Gu, Y., Wang, H., Wu, X., Huang, Z., Zhu, Y., Liu, Z., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01139-6 · Cited by 1
HARs: History, Functions, and Role in the Evolution and Pathogenesis of Human Diseases
Ryzhkova, A. S., Khabarova, A. A., Chvileva, A. S., & Шнайдер, Т. А. (2022) · Cell and Tissue Biology · doi:10.1134/s1990519x22060086 · Cited by 1
Pain, B., Aurine, N., Rosa, T. L., Baquerre, C., & Coulpier, M. (2023) · INRAE Productions Animales · doi:10.20870/productions-animales.2023.36.2.7637 · Cited by 1
Fischer, J., Peters, J., Namba, T., Huttner, W. Β., & Heide, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.01.322792 · Cited by 1
Human-specific expansion of 22q11.2 low copy repeatsPreprint
Vervoort, L., Dierckxsens, N., Pereboom, Z., Capozzi, O., Rocchi, M., Shaikh, T. H., & Vermeesch, J. R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.04.367920 · Cited by 1
Brain, Cognition, and Behavior in Humans and Other Primates
Miller, E. N., & Sherwood, C. C. (2023) · Wiley eBooks · doi:10.1002/9781119828075.ch20 · Cited by 1
Nakamura, Y., Shimada, I. S., Maroofian, R., Houlden, H., Falabella, M., Fujimoto, M., Sato, E., Takase, H., Aoki, S., Miyauchi, A., et al. (2023) · medRxiv · doi:10.1101/2023.04.26.23288947 · Cited by 1
Arellano, J. I., & RAKIC, P. T. (2023) · doi:10.1002/9781119860914.ch23 · Cited by 1
Xing, L., Pinson, A., Mora‐Bermúdez, F., & Huttner, A. W. B. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch8 · Cited by 1
Area V1 Development, a Model System to Link Corticogenesis to Adult Cortex Structure and Function
Dehay, C., & Kennedy, H. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch4 · Cited by 3
Ramani, A., Pasquini, G., Gerkau, N. J., Altinisk, N., Vinchure, O. S., Gabriel, E., Rothenaigner, I., Lin, S., Mariappan, A., Rathinam, D., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4627469 · Cited by 1
Weißbach, S., Todorov, H., Soliman, A., Schlichtholz, L., Mühlbauer, S., Zografidou, L., Lor-Zade, S., Wierczeiko, A., Strand, D. J., Strand, S., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.20.614071 · Cited by 1
Ditzer, N., Senoglu, E., Schütze, T. M., Nikolaidi, A., Kolodziejczyk, A., Sameith, K., Dietz, S., Derihaci, R. P., Birdir, C., Eugster, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.01.616076 · Cited by 2
Hu, T., Kong, Y., Tan, Y., Ma, P., Wang, J., Sun, X., Xiang, K., Mao, B., Wu, Q., Yi, S. V., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.08.627376 · Cited by 1
Zhou, X. D., Yamauchi, Y., Emoto, K., & Suzuki, I. K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.11.693619 · Cited by 1
Wang, D., Moen, M. N., Domańska, D., Zahoor, M., Cai, W., Paulsen, R. E., Utheim, T. P., Jahnsen, F. L., Storm‐Mathisen, J., & Chaudhry, F. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.16.694571 · Cited by 1
NPEPPS segmental duplication drives position effect expression of TBC1D3 in the human brainPreprint
Guitart, X., Brunner, J., Ren, L., Jeong, H., Yoo, D., Porubskỳ, D., Hoekzema, K., Munson, K. M., Sun, K. A., Ayllon, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.14.699559 · Cited by 1
Coordinated neural progenitor adaptations drive primate neocortical downscalingPreprint
Tynianskaia, L., Betancourt, C. M. B., Grewe, E. M., Kniep, J. M., Liutikaite, N., Eşiyok, N., Heide, S., Rüger, N., Lindenwald, D. L., Drummer, C., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.19.706795 · Cited by 1
Influence of cis -regulatory elements on expression divergence in human segmental duplicationsPreprint
Shew, C. J., Kaya, G., McGinty, S. P., & Dennis, M. Y. (2026) · Genome Research · doi:10.1101/gr.281526.125 · Cited by 2
Bray, N. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3944
Genetics of cortico-cerebellar expansion in anthropoid primates: a comparative approachPreprint
Harrison, P. W., & Montgomery, S. H. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/043174
Die Rolle humanspezifischer Gene in der Gehirnentwicklung und -evolution
Heide, M., Florio, M., & Huttner, W. Β. (2016) · BIOspektrum · doi:10.1007/s12268-016-0695-y
Amadei, G. (2016) · TSpace (University of Toronto)
Tavano, S., & Huttner, W. Β. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804402-5.00005-4
Herrera, R. J., & Garcia‐Bertrand, R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-804124-6.00001-x
Vadgama, N. (2017) · UCL Discovery (University College London)
MIR3607 regulates cerebral cortex development via activation of Wnt/βCat signalingPreprint
Chinnappa, K., Márquez-Galera, Á., Prieto‐Colomina, A., Nomura, Y., Cárdenas, A., López‐Atalaya, J. P., & Borrell, V. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/729939
Kawasaki, H. (2021) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.20-00198-3
Brain organoids as a model system for human neurodevelopment in health and disease
Reiner, O., & Karzbrun, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00010-2
Grundlagen und Mechanismen der Neocortex-Expansion
Heide, M., & Huttner, W. Β. (2020) · BIOspektrum · doi:10.1007/s12268-020-1411-5
Molecular mechanisms underlying malformations of cortical development
Oishi, S. (2020) · The University of Queensland · doi:10.14264/uql.2020.1023
Folds and refolds of the matter: a complex of plasticity
Debono, M.-W. (2020) · Arts et sciences · doi:10.21494/iste.op.2020.0571
Arrizabalaga, Á. R. (2020) · Espacio Tiempo y Forma Serie I Prehistoria y Arqueología · doi:10.5944/etfi.13.2020.27438
Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transportPreprint
Brault, J., Bardin, S., Lampič, M., Carpentieri, J. A., Coquand, L., Penisson, M., Lachuer, H., Victoria, G. S., Baloul, S. S., Boncompain, G., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.23.453475
Shabani, K., Pigeon, J., Zariouh, M. B. T., Liu, T., Saffarian, A., Kamatsu, J., Liu, E., Danda, N., Limame, R., Bohl, D., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3956656
Sakib, M. S. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8870 · Cited by 1
Borrell, V. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736050068.793566110
Muotri, A. R. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726777864.793560529
Gabriel, E., & Gopalakrishnan, J. (2017) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0027186
GPC3-Unc5D complex structure and role in cell migrationPreprint
Akkermans, O., Delloye‐Bourgeois, C., Peregrina, C., Carrasquero, M., Kokolaki, M. C., Berbeira-Santana, M., Chavent, M., Reynaud, F., Raj, R., Agirre, J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.21.500812
ADN, histoire de nos différences
(2020) · Odile Jacob eBooks · doi:10.3917/oj.sablo.2020.01.0231
Bozorgmehr, J. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.28.542624
Bozorgmehr, J. H. (2023) · Research Square · doi:10.21203/rs.3.rs-2996044/v1
Shinmyo, Y., & Kawasaki, H. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch24
Wu, Q., Bilgic, M., & Matsuzaki, F. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch9
Development of Cortical Neuron Heterogeneity and Impact of Neurodevelopmental Disorders
Li, Z., Tylerand, W. A., & Haydar, T. F. (2023) · doi:10.1002/9781119860914.ch12
Developmental and Evolutionary Origins of Cortical Projection Neuron Identity and Connectivity
Kaur, N., Kovner, R., Gobeske, K. T., & Šestan, N. (2023) · Wiley eBooks · doi:10.1002/9781119860914.ch13
Hongo, I., Yamaguchi, C., & Okamoto, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.23.563695
Bozorgmehr, J. H. (2024) · Research Square · doi:10.21203/rs.3.rs-2996044/v2
Extracellular matrix of the nervous system
Nazir, S., Feresten, A. H., Lin, L. D., Hutter, H., & Julian, L. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95730-4.00002-0
Huttner, W. Β. (2024) · Frontiers in Molecular Medicine · doi:10.3389/fmmed.2024.1465647
The De Novo Emergence of Two Brain Genes in the Human Lineage Appears to be Unsupported
Bozorgmehr, J. H. (2024) · Journal of Molecular Evolution · doi:10.1007/s00239-024-10227-3
Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolutionPreprint
Schütze, T. M., Ditzer, N., Vangelisti, S., Kolodziejczyk, A., Capra, E., Chiaradia, I., Peters, J., Krause, M., Oegema, C. E., Derihaci, R. P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.12.642828
Young, D. L., Aguilan, J. T., Cutler, R. R., Stransky, S., DeAngelo, J. D., Roth, J. S., Małachowska, B., Vercellino, J., Bell, B. I., Shechter, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.11.647869
Barresi, M., Johnstone, A. C., & Tolcos, M. (2025) · Developmental Neuroscience · doi:10.1159/000545713
Montag, C., & Davis, K. L. (2020) · Punctum Books · doi:10.21983/p3.0305.1.00 · Cited by 2
The genetics of human brain enlargement
Heide, M., & Huttner, W. Β. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00023-3
Zheng, J., Qi, S.-J., Wu, H., Wu, J., Chen, G., Wang, H. J., Pan, H., Li, J., Cheng, C., Tang, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.16.654402
Macciardi, F. M., Castellani, V., Fallon, J. H., & Martini, F. (2025) · L Anthropologie · doi:10.1016/j.anthro.2025.103380
Human nature in the light of molecular evolutionary biology
Vecchi, D. (2022) · Internationales Jahrbuch für Philosophische Anthropologie · doi:10.1515/jbpa-2022-0008
Neocortex Folding in Primates up to Human: Evolution and Mechanisms
Long, K. R., Huttner, W. Β., & Namba, T. (2025) · Developmental Neuroscience · doi:10.1159/000547228
Role of transketolase-like1 in human cortical neurogenesis
Pinson, A., & Huttner, W. Β. (2025) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2025.06.039
Chen, J., Li, P., Li, L., Li, J., Jiang, Y., Zou, W., Hao, P., Gao, Z., Hao, J., Shi, X., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013495
Genomic basis of human-specific brain features
Mosti, F., & Silver, D. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-27380-3.00062-2
Glucose and Oxygen Metabolism Coordinate Human Cortical Developmental DecisionsPreprint
Pennington, T. R., Morales, A. S. M., Mehdi, A., Cerna, S. A., Bamfonga, G., Chi, J., Saarinen, A. M., Wilferd, S. F., Firoz, F., Nguyen, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.02.691634
Neurotropic bornaviral pressure as a potential driver of mammalian encephalizationPreprint
Gauvain, E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.02.691862
Additional file 5 of The divergence of alternative splicing between ohnologs in teleost fishes
Wang, Y., & Guo, B. (2021) · Figshare · doi:10.6084/m9.figshare.14676647
Additional file 2 of The divergence of alternative splicing between ohnologs in teleost fishes
Wang, Y., & Guo, B. (2021) · Figshare · doi:10.6084/m9.figshare.14676638
Additional file 4 of The divergence of alternative splicing between ohnologs in teleost fishes
Wang, Y., & Guo, B. (2021) · Figshare · doi:10.6084/m9.figshare.14676644
Additional file 1 of Modelling segmental duplications in the human genome
Abdullaev, E. T., Umarova, I. R., & Arndt, P. F. (2021) · Figshare · doi:10.6084/m9.figshare.14903832
Additional file 3 of The divergence of alternative splicing between ohnologs in teleost fishes
Wang, Y., & Guo, B. (2021) · Figshare · doi:10.6084/m9.figshare.14676641
Zhang, Q., Yuan, G., Albizzati, E., Yang, J., Zhao, Z., Yu, X., Chang, X., Lee, C. H., Du, H., Lao, Z., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.27.696675
Computational reconstruction of evolutionary selection in human brain networks
Piszczek, Ł., Fazzari, C., Ulonska, S., Bühler, K., & Haubensak, W. E. (2026) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2025.1623174
Cellular scaling laws in the mammalian brain
Chen, F., & Macosko, E. Z. (2026) · Cell · doi:10.1016/j.cell.2026.08.044
Metadata
- Authors
- Florio, M., Albert, M., Taverna, E., Namba, T., Brandl, H., Lewitus, E., Haffner, C., Sykes, A., Wong, F. K., Peters, J., Guhr, E., Klemroth, S., Prüfer, K., Kelso, J., Naumann, R., Nüsslein, I., Dahl, A., Lachmann, R., Pääbo, S., & Huttner, W. B.
- Affiliations
- Max Planck Institute of Molecular Cell Biology and Genetics (DE)
- Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Pfotenhauerstraße 108, D-01307 Dresden, Germany.
- Center for Regenerative Therapies Dresden (DE)
- Max Planck Institute for Evolutionary Anthropology (DE)
- University Hospital Carl Gustav Carus (DE)
- Corresponding author
- Albert, Mareike
- Taverna, Elena
- Namba, Takashi
- ORCID
- Venue
- Science
- Published
- 2015-03-27
- Volume
- 347
- Issue
- 6229
- Pages
- 1465-1470
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985911270
- Cited by
- 632
- References
- 42
- Citations by year
- 2026: 43 · 2025: 50 · 2024: 58 · 2023: 65 · 2022: 52 · 2021: 69 · 2020: 70 · 2019: 56 · 2018: 40 · 2017: 43 · 2016: 59 · 2015: 27
- FWCI
- 22.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- European Research Council (250197)
- Deutsche Forschungsgemeinschaft (SFB 655)
- Fonds der Chemischen Industrie
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- ARHGAP11A, neocortex expansion, human brain evolution, radial glia, subventricular zone, cortical plate, cortical folding, gene duplication, RhoGAP, transcriptome, cell polarity, mouse neocortex
- MeSH terms
- Animals, Cell Separation, Humans, Neuroglia, Neurons, Protein Structure, Tertiary, Gene Expression Regulation, Developmental, Neocortex, Gene Duplication, Lateral Ventricles, GTPase-Activating Proteins, Mice, Neurogenesis, Neural Stem Cells, Transcriptome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
