The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells
Open accessAbstract
Innate lymphoid cells keep gut T cells in check: Trillions of bacteria inhabit our guts. So do many types of immune cells, including T cells, which might be expected to attack these bacteria. How, then, do our bodies manage to keep the peace? Working in mice, Hepworth et al. report one such mechanism. A population of immune cells, called innate lymphoid cells, directly killed CD4 + T cells that react to commensal gut microbes. Some of the specifics of this process parallel how the immune system keeps developing self-reactive T cells in check in the thymus. Furthermore, this peacekeeping process may be disrupted in children with inflammatory bowel disease. Science , this issue p. 1031
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Cites
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Self-citationFocused specificity of intestinal TH17 cells towards commensal bacterial antigens
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Cited by
The microbiome and innate immunity
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012
The microbiota in adaptive immune homeostasis and disease
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Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
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Homeostatic Immunity and the Microbiota
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Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
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Metadata
- Authors
- Hepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., Eberl, G., Baldassano, R. N., Laufer, T. M., Elson, C. O., & Sonnenberg, G. F.
- Venue
- Science
- Published
- 2015-05-29
- Volume
- 348
- Issue
- 6238
- Pages
- 1031-1035
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2075691631
- Cited by
- 512
- References
- 7
- FWCI
- 22.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Hepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., Eberl, G., Baldassano, R. N., Laufer, T. M., Elson, C. O., & Sonnenberg, G. F. (2015). Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells. Science. https://doi.org/10.1126/science.aaa4812
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
