The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Open accessAbstract
Early T cells keep autoimmunity at bay: A major challenge faced by the immune system is to react to foreign substances, such as microbes, while simultaneously tolerating the self. Upsetting this balance leads to autoimmunity. Regulatory T cells (T regs ), are a subset of immune cells that help to maintain this balance. Yang et al. found that murine T reg cells generated very early in life are distinct from those generated in older animals and play an especially important role in keeping autoimmunity in check (see the Perspective by Tanaka and Sakaguchi). These changes are due to differences in the way T regs develop in the thymus in newborn versus adult mice. Science , this issue p. 589 ; see also p. 506
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Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
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The inhibitory cytokine IL-35 contributes to regulatory T-cell function
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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
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Self-citationStability of the Regulatory T Cell Lineage in Vivo
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Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,120
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A weaning reaction to microbiota is required for resistance to immunopathologies in the adult
Al Nabhani, Z., Dulauroy, S., Marques, R., Cousu, C., Al Bounny, S., Déjardin, F., Sparwasser, T., Bérard, M., Cerf-Bensussan, N., & Eberl, G. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.014 · Cited by 679
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Metadata
- Authors
- Yang, S., Fujikado, N., Kolodin, D., Benoist, C., & Mathis, D.
- Venue
- Science
- Published
- 2015-05
- Volume
- 348
- Issue
- 6234
- Pages
- 589-594
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972263413
- Cited by
- 443
- References
- 41
- FWCI
- 22.53
- Type
- journal article
- Language
- en
- Open access
- green
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