The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
Open accessAbstract
Early T cells keep autoimmunity at bay: A major challenge faced by the immune system is to react to foreign substances, such as microbes, while simultaneously tolerating the self. Upsetting this balance leads to autoimmunity. Regulatory T cells (T regs ), are a subset of immune cells that help to maintain this balance. Yang et al. found that murine T reg cells generated very early in life are distinct from those generated in older animals and play an especially important role in keeping autoimmunity in check (see the Perspective by Tanaka and Sakaguchi). These changes are due to differences in the way T regs develop in the thymus in newborn versus adult mice. Science , this issue p. 589 ; see also p. 506
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3
Fontenot, J. D., Rasmussen, J. P., Williams, L. M., Dooley, J. L., Farr, A. G., & Rudensky, A. Y. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.016 · Cited by 2,279
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L. W., Workman, C. J., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R. S., & Vignali, D. A. A. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,066
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,820
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · cited 1×
“amplification and microarray hybridization were done as previously described (35, 36).”
MethodSelf-citationBrochet, X., Lefranc, M.-P., & Giudicelli, V. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn316 · Cited by 1,216
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells
Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143
Self-citationStability of the Regulatory T Cell Lineage in Vivo
Rubtsov, Y. P., Niec, R. E., Josefowicz, S., Li, L., Darce, J., Mathis, D., Benoist, C., & Rudensky, A. Y. (2010) · Science · doi:10.1126/science.1191996 · Cited by 730
Self-citationThe Cellular Mechanism of Aire Control of T Cell Tolerance
Anderson, M. S., Venanzi, E. S., Chen, Z., Berzins, S. P., Benoist, C., & Mathis, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.07.005 · Cited by 650
Self-citationHill, J. A., Feuerer, M., Tash, K., Haxhinasto, S., Perez, J., Melamed, R., Mathis, D., & Benoist, C. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.010 · Cited by 632
Self-citationConstitutive class I-restricted exogenous presentation of self antigens in vivo.
Kurts, C., Heath, W. R., Carbone, F. R., Allison, J., Miller, J. F., & Kosaka, H. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.923 · Cited by 625
Aschenbrenner, K., D'Cruz, L. M., Vollmann, E. H., Hinterberger, M., Emmerich, J., Swee, L. K., Rolink, A., & Klein, L. (2007) · Nature Immunology · doi:10.1038/ni1444 · Cited by 580
Mathis, D., & Benoist, C. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141532 · Cited by 570
Self-citationFoxp3+ regulatory T cells: differentiation, specification, subphenotypes
Feuerer, M., Hill, J. A., Mathis, D., & Benoist, C. (2009) · Nature Immunology · doi:10.1038/ni.1760 · Cited by 507
Self-citationDeletional Tolerance Mediated by Extrathymic Aire-Expressing Cells
Gardner, J. M., DeVoss, J. J., Friedman, R. S., Wong, D. J., Tan, Y. X., Zhou, X., Johannes, K. P., Su, M. A., Chang, H. Y., Krummel, M. F., et al. (2008) · Science · doi:10.1126/science.1159407 · Cited by 491
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
Malchow, S., Leventhal, D. S., Nishi, S., Fischer, B. I., Shen, L., Paner, G. P., Amit, A. S., Kang, C., Geddes, J. E., Allison, J. P., et al. (2013) · Science · doi:10.1126/science.1233913 · Cited by 328
Perry, J. S. A., Lio, C.-W. J., Kau, A. L., Nutsch, K., Yang, Z., Gordon, J. I., Murphy, K. M., & Hsieh, C.-S. (2014) · Immunity · doi:10.1016/j.immuni.2014.08.007 · Cited by 281
Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance
Hinterberger, M., Aichinger, M., Prazeres da Costa, O., Voehringer, D., Hoffmann, R., & Klein, L. (2010) · Nature Immunology · doi:10.1038/ni.1874 · Cited by 261
Toward a layered immune system
Herzenberg, L. A., & Herzenberg, L. A. (1989) · Cell · doi:10.1016/0092-8674(89)90748-4 · Cited by 258
Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)
Polanczyk, M. J., Hopke, C., Vandenbark, A. A., & Offner, H. (2007) · International Immunology · doi:10.1093/intimm/dxl151 · Cited by 254
Modifier loci condition autoimmunity provoked by Aire deficiency
Jiang, W., Anderson, M. S., Bronson, R., Mathis, D., & Benoist, C. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050693 · Cited by 243
Self-citationCell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration.
Jotereau, F., Heuze, F., Salomon-Vie, V, & Gascan, H. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.4.1026 · Cited by 220
Gotsman, I., Grabie, N., Gupta, R., Dacosta, R., MacConmara, M., Lederer, J., Sukhova, G., Witztum, J. L., Sharpe, A. H., & Lichtman, A. H. (2006) · Circulation · doi:10.1161/circulationaha.106.633263 · Cited by 215
Adaptation of TCR Repertoires to Self-Peptides in Regulatory and Nonregulatory CD4+ T Cells
Wong, J., Obst, R., Correia-Neves, M., Losyev, G., Mathis, D., & Benoist, C. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7032 · Cited by 183
Self-citationNeonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
Guerau-de-Arellano, M., Martinic, M., Benoist, C., & Mathis, D. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20090300 · Cited by 172
Self-citationAire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
Giraud, M., Yoshida, H., Abramson, J., Rahl, P. B., Young, R. A., Mathis, D., & Benoist, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119351109 · Cited by 172
Self-citationShalev, I., Liu, H., Koscik, C., Bartczak, A., Javadi, M., Wong, K. M., Maknojia, A., He, W., Liu, M. F., Diao, J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.249 · Cited by 160
Bogue, M. A., Gilfillan, S., Benoist, C. O., & Mathis, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.22.11011 · Cited by 153
Self-citationHLA-DM and HLA-DO, key regulators of MHC-II processing and presentation
Mellins, E., & Stern, L. J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.11.005 · Cited by 138
How defects in central tolerance impinge on a deficiency in regulatory T cells
Chen, Z., Benoist, C. O., & Mathis, D. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507014102 · Cited by 123
Self-citationTaniguchi, R. T., DeVoss, J., Moon, J. J., Sidney, J., Sette, A., Jenkins, M. K., & Anderson, M. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120607109 · Cited by 109
Kisand, K. E., & Peterson, P. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06308.x · Cited by 98
Wong, J., Mathis, D. J., & Benoist, C. O. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070822 · Cited by 82
Self-citationRestricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice
Baker, F. J., Lee, M., Chien, Y., & Davis, M. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142284899 · Cited by 75
Samy, E. T., Wheeler, K. M., Roper, R. J., Teuscher, C., & Tung, K. S. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.7.4366 · Cited by 72
Regulatory potential and control of Foxp3 expression in newborn CD4 + T cells
Dujardin, H. C., Burlen-Defranoux, O., Boucontet, L., Vieira, P., Cumano, A., & Bandeira, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403303101 · Cited by 68
Kanagawa, O., Militech, A., & Vaupel, B. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6159 · Cited by 68
Global relevance of Aire binding to hypomethylated lysine-4 of histone-3
Koh, A. S., Kingston, R. E., Benoist, C. O., & Mathis, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004436107 · Cited by 66
Self-citationNishio, J., Feuerer, M., Wong, J., Mathis, D. J., & Benoist, C. O. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100205 · Cited by 64
Self-citationHLA-DO and Its Role in MHC Class II Antigen Presentation
Poluektov, Y. O., Kim, A., & Sadegh‐Nasseri, S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00260 · Cited by 53
D’Alise, A. M., Ergün, A., Hill, J. A., Mathis, D. J., & Benoist, C. O. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105364108 · Cited by 39
Self-citationTun, K. S. K., Setiady, Y. Y., Samy, E. T., Lewis, J., & Teuscher, C. (2005) · Springer eBooks · doi:10.1007/3-540-27702-1_10 · Cited by 24
Cited by
Antibiotics, birth mode, and diet shape microbiome maturation during early life
Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., D. Lieber, A., Wu, F., Perez-Perez, G. I., Chen, Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7121 · Cited by 1,469
Regulatory T Cells and Human Disease
Sakaguchi, S., Mikami, N., Wing, J. B., Tanaka, A., Ichiyama, K., & Ohkura, N. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041717 · Cited by 1,120
Sun, L., Su, Y., Jiao, A., Wang, X., & Zhang, B. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01471-y · Cited by 1,014
A weaning reaction to microbiota is required for resistance to immunopathologies in the adult
Al Nabhani, Z., Dulauroy, S., Marques, R., Cousu, C., Al Bounny, S., Déjardin, F., Sparwasser, T., Bérard, M., Cerf-Bensussan, N., & Eberl, G. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.014 · Cited by 679
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Metadata
- Authors
- Yang, S., Fujikado, N., Kolodin, D., Benoist, C., & Mathis, D.
- Venue
- Science
- Published
- 2015-05
- Volume
- 348
- Issue
- 6234
- Pages
- 589-594
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972263413
- Cited by
- 443
- References
- 41
- FWCI
- 22.53
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
