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Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes
Open accessAbstract
Earliest stages of human development revealed: Most of our knowledge about meiosis in mammalian oocytes stems from studies of mouse oocytes. However, chromosome segregation in mouse oocytes is much more reliable than in human oocytes. Working with the clinic that first pioneered IVF, Holubcové et al. studied freshly harvested human oocytes. They used high-resolution fluorescence microscopy to watch more than 100 human oocytes as they went through each step of meiosis. Science , this issue p. 1143
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Mechanisms of Aneuploidy in Human Eggs
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Metadata
- Authors
- Holubcová, Z., Blayney, M., Elder, K., & Schuh, M.
- Venue
- Science
- Published
- 2015-06-05
- Volume
- 348
- Issue
- 6239
- Pages
- 1143-1147
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1946360318
- Cited by
- 324
- References
- 25
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- green
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