Cited by 863T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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The microbiota regulates type 2 immunity through RORγt + T cells

Ohnmacht, Caspar, Park, Joo-Hong, Cording, Sascha, Wing, James B., Atarashi, Koji, Obata, Yuuki, Gaboriau-Routhiau, Valérie, Marques, Rute, Dulauroy, Sophie, Fedoseeva, Maria, Busslinger, Meinrad, Cerf-Bensussan, Nadine, Boneca, Ivo G., Voehringer, David, Hase, Koji, Honda, Kenya, Sakaguchi, Shimon, Eberl, Gérard·2015·Science

DOI 10.1126/science.aac4263

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Abstract

Gut microbes make T cells keep the peace: Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht et al. and Sefik et al. characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie). Science , this issue pp. 989 and 993

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Stimulation of Tendon Healing With Delayed Dexamethasone Treatment Is Modified by the Microbiome
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Ovalbumin-Derived Peptides Activate Retinoic Acid Signalling Pathways and Induce Regulatory Responses Through Toll-Like Receptor Interactions
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Gut-eye axis
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Gastric Cancer and Microbiota: Exploring the Microbiome’s Role in Carcinogenesis and Treatment Strategies
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The NQR Complex Regulates the Immunomodulatory Function of Bacteroides thetaiotaomicron
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Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells
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Chlorinated Flame-Retardant Dechlorane 602 Potentiates Type 2 Innate Lymphoid Cells and Exacerbates Airway Inflammation
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Self-citation
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Self-citation
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Background
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BackgroundInfluential
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Background
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“7,100 Complementing this local induction pathway, CCR7 mediates intestinal DC migration to gut lymph nodes, 101 where they express RALDH enzymes that convert retinol to RA.”
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Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins
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Self-citation

Authors: Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I. G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S., & Eberl, G.
Affiliations: Institut Pasteur (FR)
Immunology Frontier Research Center, The University of Osaka (JP)
Japan Science and Technology Agency (JP)
Institute of Medical Science, The University of Tokyo (JP)
INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France.
Helmholtz Munich (DE)
Research Institute of Molecular Pathology (AT)
Inserm (FR)
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Kyoto University (JP)
Corresponding author: Ohnmacht, Caspar
Park, Joo-Hong
Eberl, Gérard
ORCID: Ohnmacht, Caspar
Cording, Sascha
Wing, James B.
Atarashi, Koji
Obata, Yuuki
Busslinger, Meinrad
Boneca, Ivo G.
Voehringer, David
Hase, Koji
Honda, Kenya
Sakaguchi, Shimon
Eberl, Gérard
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-08-28
Volume: 349
Issue: 6251
Pages: 989-993
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aac4263
OpenAlex: W2126657409
Cited by: 863
References: 53
Citations by year: 2026: 55 · 2025: 84 · 2024: 59 · 2023: 86 · 2022: 88 · 2021: 96 · 2020: 87 · 2019: 87 · 2018: 78 · 2017: 68 · 2016: 65 · 2015: 10
FWCI: 36.33
Type: journal article
Language: en
Open access: closed
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Site cant be reached (submittedVersion)
PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Funders: Boehringer Ingelheim
European Molecular Biology Organization
European Commission (MEXT-CT-2006-042374)
Agence Nationale de la Recherche (ANR 11 BSV3 020 01)
Japan Society for the Promotion of Science (15K19129)
Institut Pasteur
Fondation de la Recherche Medicale (DEq. 2010318246)
Fondation Simone e Cino Del Duca from the Institut de France
Integrative Biology of Emerging Infectious Diseases (ANR-10-LABX-62-IBEID)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: gut microbiota, Th2 immune response, RORγt, regulatory T cells, Th17 cells, Th2 cells, helminthiasis, allergic inflammation, mucosal immunity, nuclear receptors, intestinal immune regulation
MeSH terms: Animals, Colitis, Ulcerative, Colon, Germ-Free Life, Homeostasis, Intestinal Mucosa, Intestine, Small, Intestines, Nematospiroides dubius, Specific Pathogen-Free Organisms, Vitamin A, T-Lymphocyte Subsets, Strongylida Infections, Th2 Cells, Models, Immunological, Immunity, Mucosal, T-Lymphocytes, Regulatory, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota

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The microbiota regulates type 2 immunity through RORγt + T cells

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