The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
The microbiota regulates type 2 immunity through RORγt + T cells
Abstract
Gut microbes make T cells keep the peace: Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that promotes tolerance between the host and its microbial contents. Ohnmacht et al. and Sefik et al. characterized a population of gut regulatory T cells in mice, which required gut microbiota to survive. Multiple bacterial species of the microbiota could induce transcription factor–expressing regulatory T cells that helped maintain immune homeostasis. Mice engineered to lack these transcription factors exhibited enhanced susceptibility to colonic inflammation and had elevated amounts of proinflammatory molecules associated with allergies (see the Perspective by Hegazy and Powrie). Science , this issue pp. 989 and 993
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“Yet, Helios, Nrp-1 or ROR-γt are widely accepted for the discrimination of tTreg and pTreg cells under homeostatic conditions [364-366, 437-440].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [438]
In the citing paper
“In addition, the gut microbiome regulates the activity of retinoic acid receptor-related orphan receptor gamma-positive (RORγ+) Treg cells, dysregulation of which can lead to diseases such as colitis, food allergy, and colon cancer.622,701–704”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [703]
In the citing paper
“Significantly reduced RORγt+ Tregs in GF or antibiotic-treated mice promote Th2 type-associated immune responses and inflammation upon helminth infection.134”
From Interaction between microbiota and immunity in health and disease (2020) · cites this paper as [134]
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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
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Self-citationThe Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
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Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
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Self-citationCellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
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Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Self-citationCTLA-4 Control over Foxp3 + Regulatory T Cell Function
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956
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Interaction between microbiota and immunity in health and disease
Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Research · doi:10.1038/s41422-020-0332-7 · Cited by 3,947
The microbiota in adaptive immune homeostasis and disease
Honda, K., & Littman, D. R. (2016) · Nature · doi:10.1038/nature18848 · Cited by 1,846
Self-citationHomeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
“Notably, peripherally-induced Treg cells are reduced under germ free conditions (Geuking et al., 2011; Ohnmacht et al., 2015; Sefik et al., 2015; Yang et al., 2016).”
InfluentialPathophysiology of Inflammatory Bowel Diseases
Chang, J. T. (2020) · New England Journal of Medicine · doi:10.1056/nejmra2002697 · Cited by 1,295
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193
Metadata
- Authors
- Ohnmacht, C., Park, J.-H., Cording, S., Wing, J. B., Atarashi, K., Obata, Y., Gaboriau-Routhiau, V., Marques, R., Dulauroy, S., Fedoseeva, M., Busslinger, M., Cerf-Bensussan, N., Boneca, I. G., Voehringer, D., Hase, K., Honda, K., Sakaguchi, S., & Eberl, G.
- Affiliations
- Institut Pasteur (FR)
- Immunology Frontier Research Center, The University of Osaka (JP)
- Japan Science and Technology Agency (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- INSERM, U1163, Laboratory of Intestinal Immunity, Paris, France.
- Helmholtz Munich (DE)
- Research Institute of Molecular Pathology (AT)
- Inserm (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Kyoto University (JP)
- Corresponding author
- Ohnmacht, Caspar
- Park, Joo-Hong
- Eberl, Gérard
- ORCID
- Venue
- Science
- Published
- 2015-08-28
- Volume
- 349
- Issue
- 6251
- Pages
- 989-993
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2126657409
- Cited by
- 863
- References
- 53
- Citations by year
- 2026: 55 · 2025: 84 · 2024: 59 · 2023: 86 · 2022: 88 · 2021: 96 · 2020: 87 · 2019: 87 · 2018: 78 · 2017: 68 · 2016: 65 · 2015: 10
- FWCI
- 36.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Site cant be reached (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Boehringer Ingelheim
- European Molecular Biology Organization
- European Commission (MEXT-CT-2006-042374)
- Agence Nationale de la Recherche (ANR 11 BSV3 020 01)
- Japan Society for the Promotion of Science (15K19129)
- Institut Pasteur
- Fondation de la Recherche Medicale (DEq. 2010318246)
- Fondation Simone e Cino Del Duca from the Institut de France
- Integrative Biology of Emerging Infectious Diseases (ANR-10-LABX-62-IBEID)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- gut microbiota, Th2 immune response, RORγt, regulatory T cells, Th17 cells, Th2 cells, helminthiasis, allergic inflammation, mucosal immunity, nuclear receptors, intestinal immune regulation
- MeSH terms
- Animals, Colitis, Ulcerative, Colon, Germ-Free Life, Homeostasis, Intestinal Mucosa, Intestine, Small, Intestines, Nematospiroides dubius, Specific Pathogen-Free Organisms, Vitamin A, T-Lymphocyte Subsets, Strongylida Infections, Th2 Cells, Models, Immunological, Immunity, Mucosal, T-Lymphocytes, Regulatory, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota
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