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Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Open accessAbstract
Epigenetic control of caste-specific foraging: In carpenter ants, separate behavioral classes, known as castes, are determined by the epigenetic regulation of genes. Simola et al. treated ants of different castes with drugs that affected histone acetylation. Reducing histone acetylation stimulated scouting and foraging behavior. The foraging and scouting behaviors of young ants were permanently changed by directly injecting their brains with histone acetylation inhibitors. Science , this issue p. 10.1126/science.aac6633
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“Another form of environmentally induced chromatin regulation is found in social insects such as the carpenter ant Camponotus floridanus, in which the balance between morphologically distinct worker castes depends on the levels of histone acetylation, which may be influenced by feeding behaviour 82 .”
From Advances in epigenetics link genetics to the environment and disease (2019) · cites this paper as [82]
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“Comparisons between individuals from different castes have revealed that they have caste-specific DNA methylation and H3K27ac patterns that are functionally important for their behavior (Simola et al., 2016; Yan et al., 2015).”
From The Aging Epigenome (2016) · cites this paper as Simola et al., 2016
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Metadata
- Authors
- Simola, D. F., Graham, R. J., Brady, C. M., Enzmann, B. L., Desplan, C., Ray, A., Zwiebel, L. J., Bonasio, R., Reinberg, D., Liebig, J., & Berger, S. L.
- Affiliations
- University of Pennsylvania (US)
- Arizona State University (US)
- New York University (US)
- University of California, Riverside (US)
- Vanderbilt University (US)
- Corresponding author
- Simola, Daniel F.
- Graham, Riley J.
- Reinberg, Danny
- Liebig, Jürgen
- Berger, Shelley L.
- ORCID
- Venue
- Science
- Published
- 2016-01
- Volume
- 351
- Issue
- 6268
- Pages
- aac6633-aac6633
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC5057185
- OpenAlex
- W2207623969
- Cited by
- 242
- References
- 55
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 24 · 2023: 22 · 2022: 21 · 2021: 30 · 2020: 31 · 2019: 21 · 2018: 19 · 2017: 27 · 2016: 19
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute (2009005)
- NIH (T32HD083185, DP2MH107055)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Insect and Arachnid Ecology and Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- epigenetic reprogramming, Camponotus floridanus, carpenter ants, histone acetylation, histone deacetylase, Rpd3, foraging behavior, worker caste, eusocial insects, behavioral plasticity, brain transcriptome, chromatin
- MeSH terms
- Acetylation, Animals, Ants, Behavior, Animal, Chromatin, Protein Processing, Post-Translational, Social Behavior, Epigenesis, Genetic, Histone Deacetylase 2, Histone Deacetylase Inhibitors, Transcriptome
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