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T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells
Open accessAbstract
Innate immune crosstalk in T cells: The classical view of immune activation is that innate immune cells, such as macrophages and dendritic cells, recognize invading microbes and then alert adaptive immune cells, such as T cells, to respond. Arbore et al. now show that innate and adaptive immunity converge in human and mouse T cells. Activated T cells express components of the complement cascade, which in turn leads to the assembly of NLRP3 inflammasomes—both critical components of innate immunity that help hosts detect and eliminate microbes. In T cells, complement and inflammasomes work together to push T cells to differentiate into a specialized subset of T cells important for eliminating intracellular bacteria. Science , this issue p. 10.1126/science.aad1210
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Complement: a key system for immune surveillance and homeostasis
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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
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Self-citationCytokines in inflammatory bowel disease
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Ricklin, D., Reis, E. S., Mastellos, D. C., Gros, P., & Lambris, J. D. (2016) · Immunological Reviews · doi:10.1111/imr.12500 · Cited by 484
Production of complement components by cells of the immune system
Lubbers, R., van Essen, M. F., van Kooten, C., & Trouw, L. A. (2017) · Clinical and Experimental Immunology · doi:10.1111/cei.12952 · Cited by 480
Inflammasome activation at the crux of severe COVID-19
Vora, S. M., Lieberman, J., & Wu, H. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00588-x · Cited by 325
Crosstalk between the renin–angiotensin, complement and kallikrein–kinin systems in inflammation
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Complement as a regulator of adaptive immunity
Killick, J., Morisse, G., Sieger, D., & Astier, A. L. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-017-0644-y · Cited by 129
Metadata
- Authors
- Arbore, G., West, E. E., Spolski, R., Robertson, A. A. B., Klos, A., Rheinheimer, C., Dutow, P., Woodruff, T. M., Yu, Z. X., O’Neill, L. A., Coll, R. C., Sher, A., Leonard, W. J., Köhl, J., Monk, P., Cooper, M. A., Arno, M., Afzali, B., Lachmann, H. J., Cope, A. P., Mayer-Barber, K. D., & Kemper, C.
- Venue
- Science
- Published
- 2016-06-17
- Volume
- 352
- Issue
- 6292
- Pages
- aad1210-aad1210
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2420118023
- Cited by
- 513
- References
- 58
- FWCI
- 24.38
- Type
- journal article
- Language
- en
- Open access
- green
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- Arbore, G., West, E. E., Spolski, R., Robertson, A. A. B., Klos, A., Rheinheimer, C., Dutow, P., Woodruff, T. M., Yu, Z. X., O’Neill, L. A., Coll, R. C., Sher, A., Leonard, W. J., Köhl, J., Monk, P., Cooper, M. A., Arno, M., Afzali, B., Lachmann, H. J., . . . Kemper, C. (2016). T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4 + T cells. Science. https://doi.org/10.1126/science.aad1210
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